Droplet and Particle Size Relationship and Shell Thickness of Inhalable Lactose Particles During Spray Drying

Elversson, Jessica; Millqvist‐Fureby, Anna; Alderborn, Göran; Elofsson, Ulla

doi:10.1002/jps.10352

Cited by 193 publications

(124 citation statements)

References 23 publications

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“…In fact, the material undergoes many impact events before a significant quantity of the required particle size fraction is achieved and separated from the larger particles by inertial impaction, which alters the surface and solid-state properties. Intense milling can cause unwanted change in the physico-chemical properties of the material, e.g., creation of amorphous regions at the surface, which can affect hygroscopicity and stability, electrostatic charging and cohesivity [72]. It has been demonstrated that an increase in mill time results in an exponential increase in amorphous content [70].…”

Section: Millingmentioning

confidence: 99%

See 1 more Smart Citation

Lactose characteristics and the generation of the aerosol

Pilcer¹,

Wauthoz²,

Amighi³

2012

Advanced Drug Delivery Reviews

178

113

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Section: Millingmentioning

confidence: 99%

“…Moreover, it has been demonstrated that the nozzle orifice diameter and airflow control the droplet size during atomisation [72]. Increasing the droplet size increases the particle size, but the effect is also influenced by the feed concentration.…”

Section: Spray-dryingmentioning

confidence: 99%

Lactose characteristics and the generation of the aerosol

Pilcer¹,

Wauthoz²,

Amighi³

2012

Advanced Drug Delivery Reviews

178

113

View full text Add to dashboard Cite

“…Moreover, there is a clear need of an alternative method for preparation of formulation with lesser time and easy scalability. Spray drying is widely employed in microparticle preparation due to the uniform size distribution of the product and advantages of one-step formulation and drying process (22,23). In a quest for an industrially viable, easily scalable method with a capability of modulating the size and thereby dissolution characteristics, we have developed novel co-spray dried rifampicin phospholipid lipospheres (SDRPL) by spray drying technology.…”

Section: Introductionmentioning

confidence: 99%

In Vitro-In Vivo Evaluation of Novel Co-spray Dried Rifampicin Phospholipid Lipospheres for Oral Delivery

Singh¹,

Koduri²,

Bhatt³

et al. 2016

AAPS PharmSciTech

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Abstract. The objective of this study comprises of developing novel co-spray dried rifampicin phospholipid lipospheres (SDRPL) to investigate its influence on rifampicin solubility and oral bioavailability. Solid-state techniques were employed to characterize the liposphere formulation. SDRPL solubility was determined in distilled water. BACTEC 460TB System was employed to evaluate SDRPL antimycobacterial activity. The oral bioavailability of the lipospheres was evaluated in Sprague Dawley rats. Lipospheres exhibited amorphous, smooth spherical morphology with a significant increase (p < 0.001) in solubility of SDRPL (2:1), 350.9 ± 23 versus 105.1 ± 12 μg/ml and SDRPL (1:1) 306.4 ± 20 versus 105.1 ± 12 μg/ml in comparison to rifampicin (RMP). SDRPL exhibited enhanced activity against Mycobacterium tuberculosis, H37Rv strain, with over twofolds less minimum inhibitory concentration (MIC) than the free drug. Lipospheres exhibited higher peak plasma concentration (109.92 ± 25 versus 54.31 ± 18 μg/ml), faster T max (two versus four hours), and enhanced area under the curve (AUC 0-∞ ) (406.92 ± 18 versus 147.72 ± 15 μg h/L) in comparison to pure RMP. Thus, SDRPL represents a promising carrier system exhibiting enhanced antimycobacterial activity and oral bioavailability of rifampicin.

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“…When drying occurs at high temperatures, cycles of repeated expansion and collapse of the particle occur because of the formation of an internal air bubble (Elversson et al, 2003;Elversson & Millqvist-Fureby, 2005;Walton & Mumford, 1999). However, the largest effect on particle morphology was caused by the composition and solid materials contained in the liquid to be sprayed (Vehring, 2008;Elversson et al, 2003;Elversson & Millqvist-Fureby, 2005;Walton & Mumford, 1999). As shown in Figures 2b and 2c, the surface corrugation of particles was observed when the extraction temperature increased (i.e., 453K and 463K).…”

Section: Resultsmentioning

confidence: 99%

Subcritical Water Extraction and Direct Formation of Microparticulate Polysaccharides Powders from Ganoderma Lucidum

Matsunaga

Machmudah

Wahyudiono

et al. 2014

IJTech

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Ganoderma lucidum (hereafter G. lucidum) has been known as a food and raw material used in the development of medications because of its high content of polysaccharides, or β-glucans, which support the immune function. In this work, subcritical water was applied to utilize G. lucidum for the extraction of polysaccharides at temperatures of 373-463K and a pressure level of 4.0 MPa using a semi-batch system. Furthermore, these extracts were atomized and contacted with hot air to produce microsphere particles. During extraction, thermal softening of G. lucidum occurred, allowing the removal of the polysaccharides and protecting other constituents in G. lucidum via hydrolysis. Scanning electron microscope (SEM) images showed that the microsphere particles formed were spherical and dimpled or shriveled particles with diameters varying from 1 to 6 m. Characteristics of the molecular mass revealed that main massed peaks of water soluble products were distributed at around 688-2636 m/z with a peakto-peak mass difference of 162 m/z, consistent with the repeating unit of the glucans.

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Droplet and Particle Size Relationship and Shell Thickness of Inhalable Lactose Particles During Spray Drying

Cited by 193 publications

References 23 publications

Lactose characteristics and the generation of the aerosol

Lactose characteristics and the generation of the aerosol

In Vitro-In Vivo Evaluation of Novel Co-spray Dried Rifampicin Phospholipid Lipospheres for Oral Delivery

Subcritical Water Extraction and Direct Formation of Microparticulate Polysaccharides Powders from Ganoderma Lucidum

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