Dropless Cataract Surgery: What Are the Potential Downsides?

Stringham, Jack; Flynn, Harry W.; Schimel, Andrew M.; Banta, James T.

doi:10.1016/j.ajo.2016.02.001

Cited by 22 publications

(15 citation statements)

References 14 publications

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“…Currently, there is growing interest in so-called dropless cataract surgery, where drug-loaded devices can provide adequate medical treatment to prevent postoperative inflammation. [32][33][34] In the United States, Imprimis Pharmaceuticals (San Diego, CA) devel-oped TriMoxi (less drops) and TriMoxiVanc (dropless), two compounded injections that consists of Triamcinolone and Moxifloxacin for perioperative use. 32,34 They estimated that as such the use of postoperative drops can be avoided in more than 90% of patients.…”

Section: Discussionmentioning

confidence: 99%

Safety and Comfort of an Innovative Drug Delivery Device in Healthy Subjects

Bertens

Dunker

Dias³

et al. 2020

Trans. Vis. Sci. Tech.

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Purpose The aim of this study was to investigate safety and comfort of two versions of a placebo-microsphere filled ocular coil (straight and curved) in healthy subjects. Methods The study was a single-center intervention study. One ocular coil was placed in the inferior conjunctival fornix for the intended duration of 28 days. Forty-two healthy adult subjects were included. At baseline, 30 minutes, 8 hours, 24 hours, 48 hours, 7 days, 14 days, 21 days, and 28 days after insertion, examinations were performed, including slit lamp evaluation to score ocular redness, intraocular pressure measurement, visual acuity, tear secretion test, and questionnaires. Results The straight and curved ocular coils had a median retention time of 5 days and 12 days, respectively. After 48 hours, 57% and 81% subjects retained the straight and curved ocular coil, respectively. Four (19%) subjects with the straight coil and six (29%) with the curved coil completed the entire study period. Minor changes in ocular hyperemia were observed in both groups. On day 7, the straight coil was more comfortable than the curved coil with a visual analogue scale (VAS) score of 77 ± 21 compared to 94 ± 11 ( P = 0.028), respectively. No other ocular adverse events were observed. Conclusions Comfort and safety of the straight and curved ocular coil are high. Because the retention time is too short for long-term sustained drug release, the use in the perioperative or immediate postoperative period could prove to be more valuable. Translational Relevance The ocular coil is a noninvasive, comfortable and safe short-term drug delivery device.

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Section: Discussionmentioning

confidence: 99%

Safety and Comfort of an Innovative Drug Delivery Device in Healthy Subjects

Bertens

Dunker

Dias³

et al. 2020

Trans. Vis. Sci. Tech.

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show abstract

“…According to reports on dropless cataract surgeries, as little as 5% of the patients needed drops with the Tri-Moxi experience, while the rest of the patients didn't experience any problem. 10 It is a known fact that compliance of eye drops as well as poor adherence to medication after surgery, are major issues. Moreover, the patients are also less likely to admit their poor adherence in hopes of not disappointing www.djo.org.in Delhi Journal of Ophthalmology their doctors, which results in worsening the problem.…”

Section: Dropless Cataract Surgerymentioning

confidence: 99%

Drug Delivery Innovation during Cataract Surgery: Are We Ready for Dropless Cataract Surgery?

Pandey¹

2019

DJO

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Cataract-intraocular lens (IOL) surgery is the most common procedure performed by ophthalmic surgeons worldwide. Currently, topical administration is the most common route of ocular drug delivery during cataract surgery. Despite its apparent easy accessibility, the eye is well protected from foreign materials and drugs by a number of very efficient mechanisms such as blinking, induced lacrimation, tear turnover, nasolacrimal drainage, which cause rapid removal of substances from the eye surface and by the cornea, which forms the physical-biological barrier.

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“…According to reports on dropless cataract surgeries, as little as 5% of the patients needed drops with the Tri-Moxi experience, while the rest of the patients did not experience any problem. [ 10 ] It is a known fact that compliance of eye drops as well as poor adherence to medication after surgery are major issues. Moreover, the patients are also less likely to admit their poor adherence in hope of not disappointing their doctors, which results in worsening the problem.…”

mentioning

confidence: 99%

Transzonular drug delivery during cataract surgery: Is dropless cataract surgery really beneficial?

Pandey

2018

Indian J Ophthalmol

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Dropless Cataract Surgery: What Are the Potential Downsides?

Cited by 22 publications

References 14 publications

Safety and Comfort of an Innovative Drug Delivery Device in Healthy Subjects

Safety and Comfort of an Innovative Drug Delivery Device in Healthy Subjects

Drug Delivery Innovation during Cataract Surgery: Are We Ready for Dropless Cataract Surgery?

Transzonular drug delivery during cataract surgery: Is dropless cataract surgery really beneficial?

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