Droperidol for treatment of nausea and vomiting in palliative care patients

Dorman, Saskie; Perkins, Paul

doi:10.1002/14651858.cd006938.pub2

Cited by 10 publications

(3 citation statements)

References 32 publications

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“…Previous reviews have cited problems defining the population for systematic reviews in palliative care. Therefore, we drew upon the definition that other Cochrane reviews have used, "adult patients in any setting, receiving palliative care or suffering an incurable progressive medical condition" (Dorman 2010;Perkins 2009). Studies eligible for this review included participants:…”

Section: Types Of Participantsmentioning

confidence: 99%

“…Previous reviews have reported difficulties in defining the population of palliative care patients. Therefore, we used the definition 'adult patients in any setting, receiving palliative care or suffering an incurable progressive medical condition', which has previously been used in other Cochrane reviews (Dorman 2010;Perkins 2009). However, it is still difficult to identify the patients or patient groups who are appropriate to be included in a systematic review on palliative care topics, as there is still a lack of original studies, particularly RCTs, in palliative care.…”

Section: Potential Biases In the Review Processmentioning

confidence: 99%

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Pharmacological interventions for pruritus in adult palliative care patients

Siemens

Xander

Meerpohl

et al. 2016

Cochrane Database of Systematic Reviews

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Analysis 2.1. Comparison 2 Nalfurafine versus placebo, Outcome 1 A) Pruritus on VAS scale (0-10 cm) in UP participants; parallel-group design; Wikström b: Wikström a (week 2) + period 1 Wikström b.. .. .. .. .. . Analysis 2.2. Comparison 2 Nalfurafine versus placebo, Outcome 2 A) Sensitivity analysis: random-effects model; pruritus on VAS scale (0-10 cm) in UP participants; parallel-group design; Wikström b: Wikström a (week 2) + period 1

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Section: Types Of Participantsmentioning

confidence: 99%

Section: Potential Biases In the Review Processmentioning

confidence: 99%

Pharmacological interventions for pruritus in adult palliative care patients

Siemens

Xander

Meerpohl

et al. 2016

Cochrane Database of Systematic Reviews

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“…92,93 Two recent Cochrane reviews (one on haloperidol and the other on droperidol) revealed that highquality studies are lacking, and additional studies in palliative care are necessary. 91,94 Butyrophenones are preferred to phenothiazines (chlorpromazine and levomepromazine), which induce severe sedative and anticholinergic side effects although they are particularly effective for intractable vomiting (chlorpromazine).…”

Section: Antiemetic Managementmentioning

confidence: 99%

Recommendations for Bowel Obstruction With Peritoneal Carcinomatosis

Laval¹,

Marcelin-Benazech

Guirimand

et al. 2014

Journal of Pain and Symptom Management

117

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This article reports on the clinical practice guidelines developed by a multidisciplinary group working on the indications and uses of the various available treatment options for relieving intestinal obstruction or its symptoms in patients with peritoneal carcinomatosis. These guidelines are based on a literature review and expert opinion. The recommended strategy involves a clinical and radiological evaluation, of which CT of the abdomen is a crucial component. The results, together with an analysis of the prognostic criteria, are used to determine whether surgery or stenting is the best option. In most patients, however, neither option is feasible, and the main emphasis, therefore, is on the role and administration of various symptomatic medications such as glucocorticoids, antiemetic agents, analgesics, and antisecretory agents (anticholinergic drugs, somatostatin analogues, and proton-pump inhibitors). Nasogastric tube feeding is no longer used routinely and should instead be discussed on a case-by-case basis. Recent studies have confirmed the efficacy of somatostatin analogues in relieving obstruction-related symptoms such as nausea, vomiting, and pain. However, the absence of a marketing license and the high cost of these drugs limit their use as the first-line treatment, except in highly selected patients (early recurrence). When these medications fail to alleviate the symptoms of obstruction, venting gastrostomy should be considered promptly. Rehydration is needed for virtually every patient. Parenteral nutrition and pain management should be adjusted according to the patient needs and guidelines.

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