Drooling rating scales in Parkinson's disease: A systematic review

Nascimento, David; Carmona, J. Martínez; Mestre, Tiago; Ferreira, Joaquim J.; Guimarães, Isabel

doi:10.1016/j.parkreldis.2021.09.012

Cited by 15 publications

(15 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This is partly due to different tools such as the UPDRS-II, SCOPA-AUT (Scale for Outcomes in Parkinson's disease for Autonomic Symptoms), PD-NMSQuest (Parkinson's Disease Nonmotor Symptoms Questionnaire), NMSS, or different types of screening questionnaires have been used to screen drooling in PD cohorts with different characteristics also [ 1 , 3 , 11 ]. Some specific scales to assess drooling have been designed, but they have been poorly used in studies with PD patients [ 37 ]. Using the NMSS-item 19 for detecting drooling like us, van Wamelen et al [ 23 ] detected in a cohort of 728 PD patients with a mean disease duration of 5.6 years a prevalence of 37.2% at the baseline and 40.1% after a mean follow-up of 3.3 years (range 0.5–7.2 years).…”

Section: Discussionmentioning

confidence: 99%

“…The Picillo study, in addition to ours and other studies, suggests that drooling could be more frequent in males [ 3 , 11 , 28 , 40 ]. Although specifically well-designed studies to analyze the prevalence of drooling using specific validated scales [ 37 , 41 ] in large cohorts are required, all these data suggest a recommendation to rule out drooling in PD patients at the beginning and throughout follow-up since its presence is associated with a worse QoL and it is potentially treatable. Consideration is especially valid in elderly men for which the prevalence of drooling is more frequent.…”

Section: Discussionmentioning

confidence: 99%

“…The present study has some important limitations. Drooling was considered based on an answer to a simple clinical question from the NMSS and not after using a specific scale [ 37 , 41 ]. However, this methodology is the most frequent in most studies [ 2 , 3 , 6 , 7 , 11 , 24 , 40 , 47 , 48 ].…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group

Santos‐García

Fonticoba

Bartolomé

et al. 2023

Parkinson's Disease

View full text Add to dashboard Cite

Introduction. Drooling in Parkinson’s disease (PD) is frequent but often goes underrecognized. Our aim was to examine the prevalence of drooling in a PD cohort and compare it with a control group. Specifically, we identified factors associated with drooling and conducted subanalyses in a subgroup of very early PD patients. Patients and Methods. PD patients who were recruited from January 2016 to November 2017 (baseline visit; V0) and evaluated again at a 2-year ± 30-day follow-up (V2) from 35 centers in Spain from the COPPADIS cohort were included in this longitudinal prospective study. Subjects were classified as with or without drooling according to item 19 of the NMSS (Nonmotor Symptoms Scale) at V0, V1 (1-year ± 15 days), and V2 for patients and at V0 and V2 for controls. Results. The frequency of drooling in PD patients was 40.1% (277/691) at V0 (2.4% (5/201) in controls; p < 0.0001), 43.7% (264/604) at V1, and 48.2% (242/502) at V2 (3.2% (4/124) in controls; p < 0.0001), with a period prevalence of 63.6% (306/481). Being older (OR = 1.032; p = 0.012), being male (OR = 2.333; p < 0.0001), having greater nonmotor symptom (NMS) burden at the baseline (NMSS total score at V0; OR = 1.020; p < 0.0001), and having a greater increase in the NMS burden from V0 to V2 (change in the NMSS total score from V0 to V2; OR = 1.012; p < 0.0001) were identified as independent predictors of drooling after the 2-year follow-up. Similar results were observed in the group of patients with ≤2 years since symptom onset, with a cumulative prevalence of 64.6% and a higher score on the UPDRS-III at V0 (OR = 1.121; p = 0.007) as a predictor of drooling at V2. Conclusion. Drooling is frequent in PD patients even at the initial onset of the disease and is associated with a greater motor severity and NMS burden.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group

Santos‐García

Fonticoba

Bartolomé

et al. 2023

Parkinson's Disease

View full text Add to dashboard Cite

show abstract

“…First, we qualitatively and quantitatively measured the patient's baseline degree of sialorrhea. We used the Sialorrhea Scoring Scale ( Table 1 ), 5 , 6 , 7 , 8 which was developed for Parkinson's disease and validated for ALS, as well the Oral Secretion Scale ( Table 2 ), 9 , 10 , 11 , 12 which was designed specifically for sialorrhea in ALS. These scales are both simple rating tools in which patients report the severity of their sialorrhea symptoms.…”

Section: Casementioning

confidence: 99%

Using Intensity Modulated Radiation Therapy for the Treatment of Sialorrhea in Amyotrophic Lateral Sclerosis

Ati¹,

Chhetri²,

Wiedau³

et al. 2023

Advances in Radiation Oncology

View full text Add to dashboard Cite

“…They should also include the examination of biochemical properties of saliva, its appearance, viscosity, flow, and volume, as well as the association between the degree of drooling severity and patients’ clinical characteristics. Interestingly, a study found that the Radboud Oral Motor inventory for Parkinson’s disease—Saliva (ROMP-saliva) scale is the only scale with data on patients with PD and clinimetric properties adequacy [ 62 ].…”

Section: Limitations and Future Directionsmentioning

confidence: 99%

Pathophysiology and Symptomatology of Drooling in Parkinson’s Disease

et al. 2022

View full text Add to dashboard Cite

Drooling can present in patients with Parkinson’s disease (PD), and it is manifested as an excessive pooling of saliva inside the oral cavity. Currently, the exact pathophysiological mechanism of drooling in PD is not yet fully explicated. Thus, it becomes crucial to understand if some clinical characteristics may emphasize drooling or if they are just concomitant. In PD, excessive drooling has been associated with a higher burden of non-motor symptoms, such as cognitive impairment, sleep problems, autonomic dysfunction, constipation and orthostatic hypotension, and of worse severity of motor fluctuations and bradykinesia. PD patients with excessive drooling also showed a reduction of striatal DAT availability at DaTSCAN imaging. Excessive drooling in patients with Parkinson’s cannot be attributed to a single factor but to a mixture of factors, including but not limited to impaired nigrostriatal pathways.

show abstract

Drooling rating scales in Parkinson's disease: A systematic review

Cited by 15 publications

References 51 publications

Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group

Prevalence and Factors Associated with Drooling in Parkinson’s Disease: Results from a Longitudinal Prospective Cohort and Comparison with a Control Group

Using Intensity Modulated Radiation Therapy for the Treatment of Sialorrhea in Amyotrophic Lateral Sclerosis

Pathophysiology and Symptomatology of Drooling in Parkinson’s Disease

Contact Info

Product

Resources

About