Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness

Sabelström, Hanna; Petri, Rebecca; Shchors, Ksenya; Jandial, Rahul; Schmidt, Christin; Sacheva, Rohit; Masic, Selma; Yuan, Edith; Fenster, Trenten; Martinez, Michael; Saxena, Supna; Nicolaides, Theodore; Ilkhanizadeh, Shirin; Berger, Mitchel S.; Snyder, Evan Y.; Weiss, William A.; Jakobsson, Johan; Persson, Anders I.

doi:10.1016/j.celrep.2019.07.071

Cited by 42 publications

(27 citation statements)

References 94 publications

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“…In the central nervous system, Sox9 plays an important role in the differentiation of cranial neural crest cells (8), and was reported as an astrocyte-specific nuclear marker in adult brain outside the neurogenic regions (33). We found here that Sox9 was overexpressed in clinical gliomas, and correlated with a poor prognosis of glioma patients.…”

Section: Discussionsupporting

confidence: 57%

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TGF-β Signaling Promotes Glioma Progression Through Stabilizing Sox9

et al. 2021

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Gliomas are brain and spinal cord malignancies characterized by high malignancy, high recurrence and poor prognosis, the underlying mechanisms of which remain largely elusive. Here, we found that the Sry-related high mobility group box (Sox) family transcription factor, Sox9, was upregulated and correlated with poor prognosis of clinical gliomas. Sox9 promotes migration and invasion of glioma cells and in vivo development of xenograft tumors from inoculated glioma cells. Sox9 functions downstream of the transforming growth factor-β (TGF-β) pathway, in which TGF-β signaling prevent proteasomal degradation of the Sox9 protein in glioma cells. These findings provide novel insight into the wide interplay between TGF-β signaling and oncogenic transcription factors, and have implications for targeted therapy and prognostic assessment of gliomas.

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Section: Discussionsupporting

confidence: 57%

“…Genetic mutation is known to drive malignant transformation at least in part by "hijacking" neurodevelopmental programs (4,5). Increasing evidence has suggested that Sox9, an indispensable transcription factor in the development of the nervous system, plays a pivotal role in the pathogenesis of glioma (6)(7)(8).…”

Section: Introductionmentioning

confidence: 99%

TGF-β Signaling Promotes Glioma Progression Through Stabilizing Sox9

et al. 2021

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“…TRIzol solution was used for total RNA extraction from cells and harvested tissues. Cycling conditions were set as previously mentioned, 19 and the genes expression was normalized to ARF5 and U6. A melting curve confirmed the specificity of the amplification products.…”

Section: Methodsmentioning

confidence: 99%

miR‐5188 augments glioma growth, migration and invasion through an SP1‐modulated FOXO1‐PI3K/AKT‐c‐JUN‐positive feedback circuit

Yang

Lin

et al. 2020

J Cellular Molecular Medi

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“…[1440] MicroRNA also acts as a regulator for neurogenesis. [4142] Possibly, the identification of some exosomal cargoes[43] might be an easier task compared to the identification of the soluble proteins and lipids present in the EPC-CM.…”

Section: Endothelial Progenitor Cell-derived Conditioned Medium Incrementioning

confidence: 99%

Another win for endothelial progenitor cells: Endothelial progenitor cell-derived conditioned medium promotes proliferation and exerts neuroprotection in cultured neuronal progenitor cells

Sadanandan

Santo

2019

Brain Circ

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Progress in stem cell research demonstrates stem cells' potential for treating neurodegenerative diseases. Stem cells have proliferative/differentiative properties and produce a variety of paracrine factors that can potentially be used to regenerate nervous tissue. Previous studies have shown the positive regenerative effects of endothelial progenitor cells (EPCs), and thus, they may be used as a tool for regeneration. A study by Di Santo et al. explored whether EPC-derived conditioned medium (EPC-CM) promotes the survival of cultured striatal progenitor cells and attempted to find the paracrine factors and signaling pathways involved with EPC-CM's effects. The neuronal progenitor cells that were cultured with EPC-CM had much higher densities of GABA-immunoreactive (GABA-ir) neurons. It was shown that phosphatidylinositol-3-kinase/AKT and mitogen-activated protein kinase/ERK signaling pathways are involved in the proliferation of GABAergic neurons, as inhibition of these pathways decreased GABAergic densities. In addition, the results suggest that paracrine factors from EPC, both proteinaceous and lipidic, significantly elevated the viability and/or differentiation in the cultures. Importantly, it was found that EPC-CM provided neuroprotection against toxins from 3-nitropropionic acid. In sum, EPC-CM engendered proliferation and regeneration of the cultured striatal cells through paracrine factors and imparted neuroprotection. Furthermore, the effects of EPC-CM may generate a cell-free therapeutic strategy to address neurodegeneration.

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Driving Neuronal Differentiation through Reversal of an ERK1/2-miR-124-SOX9 Axis Abrogates Glioblastoma Aggressiveness

Cited by 42 publications

References 94 publications

TGF-β Signaling Promotes Glioma Progression Through Stabilizing Sox9

TGF-β Signaling Promotes Glioma Progression Through Stabilizing Sox9

miR‐5188 augments glioma growth, migration and invasion through an SP1‐modulated FOXO1‐PI3K/AKT‐c‐JUN‐positive feedback circuit

Another win for endothelial progenitor cells: Endothelial progenitor cell-derived conditioned medium promotes proliferation and exerts neuroprotection in cultured neuronal progenitor cells

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