Driving Abilities in Frontotemporal Dementia Patients

Simone, V. de; Kaplan, Lauren M.; Patronas, Nicholas J.; Wassermann, Eric M.; Grafman, Jordan

doi:10.1159/000096317

Cited by 45 publications

(42 citation statements)

References 105 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increased recognition of FTD in the elderly has important consequences for dementia care. Compared to AD, patients with FTD often require other strategies for psychosocial support and nursing [2], have no effect of treatments with choline esterase inhibitors or memantin [2], [36], and are unsuitable as drivers at an earlier stage of the disease process compared to AD [37]. As the majority of patients with FTD in SveDem were above 65 years at diagnosis, our findings could also be important in the recruitment of patients for clinical trials.…”

Section: Discussionmentioning

confidence: 82%

Age-Related Incidence and Family History in Frontotemporal Dementia: Data from the Swedish Dementia Registry

et al. 2014

View full text Add to dashboard Cite

ObjectivesFrontotemporal dementia (FTD) is considered to be a mainly early-onset neurodegenerative disorder with a strong hereditary component. The aim of the study was to investigate age-related incidence and family history in FTD compared to other dementia disorders, especially Alzheimer's disease (AD).MethodsThe Swedish Dementia Registry (SveDem) registers all new cases of dementia diagnosed by the participating centres, including data on demographics, diagnosis, and investigations used. Data for the period 2008–2011 were extracted and compared with age-related population data on a regional and national level.ResultsThere were 20 305 patients registered in SveDem during 2008–2011, whereof 352 received a diagnosis of FTD. Mean age at diagnosis for FTD was 69.6 years and almost 70% of FTD cases were 65 years or older at the time of diagnosis. Both FTD and AD showed an increased incidence with age, which reached a maximum in the age group 80–84 years at 6.04 and 202 cases per 100 000 person-years, respectively. The proportion of cases with a positive family history was significantly lower in FTD than in AD.ConclusionsContrary to general opinion within the field, data from SveDem show that the incidence of FTD increases with age, and that the majority of cases are diagnosed after the age of 65 years. In addition, data from SveDem might suggest that the importance of hereditary factors in general is similar in FTD and AD. The recognition of these findings has important consequences for the diagnosis, treatment and care of patients with FTD.

show abstract

Section: Discussionmentioning

confidence: 82%

Age-Related Incidence and Family History in Frontotemporal Dementia: Data from the Swedish Dementia Registry

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Limited evidence comes from the focal syndromes of the frontotemporal lobe degeneration,12 which, although less frequent than AD, are the second most common cause of early onset dementias 13. A single study on case-series was found in the behavioural variant of frontotemporal dementia (FTD) 14. Fifteen patients with a diagnosis of FTD were administered a driving simulation task, and it was found that, compared to controls, patients with FTD received more speeding tickets, ran more stop signs and were involved in more off-road crashes and collisions than controls.…”

Section: Introductionmentioning

confidence: 99%

The neural correlates of road sign knowledge and route learning in semantic dementia and Alzheimer's disease

Luzzi

Cafazzo

Damora

et al. 2014

J Neurol Neurosurg Psychiatry

View full text Add to dashboard Cite

“…It is difficult to ascertain the extent to which drivers are engaging in self-regulation as self-report depends upon the driver's memory of the event, which may be diminished due to cognitive decline, and can change over time. It has been estimated that older drivers with cognitive impairment often overestimate both their driving and functional abilities [42,43] and recent evidence suggests that this lack of accuracy may be correlated with degree of cognitive impairment [43].…”

Section: Discussionmentioning

confidence: 99%