Thermodynamic arguments imply that global mean rainfall increases in a warmer atmosphere; however, dynamical effects may result in more significant diversity of regional precipitation change. Here we investigate rainfall changes in the mid-Pliocene Warm Period (~ 3 Ma), a time when temperatures were 2-3ºC warmer than the pre-industrial era, using output from the Pliocene Model Intercomparison Projects phases 1 and 2 and sensitivity climate model experiments. In the Mid-Pliocene simulations, the higher rates of warming in the northern hemisphere create an interhemispheric temperature gradient that enhances the southward cross-equatorial energy flux by up to 48%. This intensified energy flux reorganizes the atmospheric circulation leading to a northward shift of the Inter-Tropical Convergence Zone and a weakened and poleward displaced Southern Hemisphere Subtropical Convergences Zones. These changes result in drier-than-normal Southern Hemisphere tropics and subtropics. The evaluation of the mid-Pliocene adds a constraint to possible future warmer scenarios associated with differing rates of warming between hemispheres. The Earth has experienced many periods in which climate was warmer than present. Understanding atmospheric circulation and precipitation during past warm climates is useful to produce constraints on possible future changes. Here we analyse the Southern Hemisphere large-scale rainfall response in the mid-Pliocene Warm Period (~ 3 Ma mPWP; hereafter referred as mid-Pliocene). During this period high-latitude Sea Surface Temperatures (SST) were as high as + 9 °C and + 4 °C in the Northern and Southern Hemisphere, respectively 1 , compared to pre-industrial times (~ 1850 Common Era [C.E.]; Fig. 1). In addition, the Greenland ice sheet had 50-70% 2-4 less mass and the western Antarctica was ice-free 5,6. Atmospheric CO 2 concentrations were similar to today 7 (~ 400 ppm). Although the extent of the ice sheets for the end of the twenty-first century is still a topic of debate, especially due to model's limitations in simulating land-ice processes 8,9 , the mid-Pliocene is considered a useful analogue for the end-of-century climate 10. Rainfall proxy archives do not exist for the tropics and Southern Hemisphere subtropics in the mid-Pliocene. However, paleo reconstructions of ice sheets, SSTs, vegetation distribution, soils and lakes performed by the Pliocene Research, Interpretation and Synoptic Mapping (PRISM) project 1 are available to force climate models 4,12