Drinking-Water Disinfection By-products and Semen Quality: A Cross-Sectional Study in China

Zeng, Qiang; Wang, Yi‐Xin; Xie, Shao-Hua; Xu, Liang; Yong-zhe, Chen; Li, Min; Yue, Jing; Li, Yufeng; Liu, Ai-Lin; Lu, Wen-Qing

doi:10.1289/ehp.1307067

Cited by 58 publications

(20 citation statements)

References 36 publications

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“…In humans, the data are less clear. Using urinary trichloroacetic acid as a marker of exposure, increased exposure was associated with lower sperm concentrations in Chinese men (Zeng et al ., ). A separate study in China found a trend toward lower sperm concentrations with higher serum trihalomethane levels (Zeng et al ., ).…”

Section: Ambient and Other Occupational Exposuresmentioning

confidence: 97%

Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis

2016

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SUMMARYSeveral recent studies have suggested that sperm concentrations and semen quality have been decreasing over the past several decades in many areas of the world. The etiology of these decreases is currently unknown. Acute events can have significant impacts on spermatogenesis and are often readily identified during the male fertility evaluation. The majority of male factor infertility, however, is idiopathic. Chronic, low-dose exposures to chemicals and nutrients are more difficult to identify, but are extremely prevalent. These exposures have been shown to have dramatic effects on both individual and community health and interest in the cumulative and synergistic impacts of such agents on spermatogenesis has been increasing. While our understanding of these potential hazards is evolving, it is clear that they may significantly influence male reproductive potential. This review explores the literature related to effects of chronic exposures from drug use, dietary intake, and the environment on spermatogenesis in humans and animals.

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Section: Ambient and Other Occupational Exposuresmentioning

confidence: 97%

Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis

2016

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“…A large case-control study conducted in the UK reported no evidence of poor semen quality in association with total trihalomethanes (THMs), chloroform, or brominated THMs in public drinking water [61]. In China, a cross-sectional study that measured urine TCAA in approximately 2,000 men visiting a reproduction center showed a negative correlation between markers of sperm quality and urine TCAA levels, but no dose-response association was observed [62]. Menstrual parameters as measured by urinary steroid metabolites over a period of six months were collected among a group of 403 women, together with water use habits and THM levels at the residence.…”

Section: Fertilitymentioning

confidence: 99%

Overview of Disinfection By-products and Associated Health Effects

Villanueva

Cordier²,

Font-Ribera

et al. 2015

Curr Envir Health Rpt

226

124

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The presence of chemical compounds formed as disinfection by-products (DBPs) is widespread in developed countries, and virtually whole populations are exposed to these chemicals through ingestion, inhalation, or dermal absorption from drinking water and swimming pools. Epidemiological evidence has shown a consistent association between long-term exposure to trihalomethanes and the risk of bladder cancer, although the causal nature of the association is not conclusive. Evidence concerning other cancer sites is insufficient or mixed. Numerous studies have evaluated reproductive implications, including sperm quality, time to pregnancy, menstrual cycle, and pregnancy outcomes such as fetal loss, fetal growth, preterm delivery, and congenital malformation. The body of evidence suggests only minor effects from high exposure during pregnancy on fetal growth indices such as small for gestational age (SGA) at birth. Populations highly exposed to swimming pools such as pool workers and professional swimmers show a higher prevalence of respiratory symptoms and asthma, respectively, although the direction of the association, and thus causality, is not clear among professional swimmers. The risk of asthma, wheezing, eczema, and other respiratory outcomes among children attending swimming pools has been the object of extensive research. Early studies suggested a positive association, while subsequent larger studies found no correlations or showed a protective association. Future research should develop methods to evaluate the effects of the DBP mixture and the interaction with personal characteristics (e.g., genetics, lifestyle), clarify the association between swimming pools and respiratory health, evaluate the occurrence of DBPs in lowand middle-income countries, and evaluate outcomes suggested by animal studies that have not been considered in epidemiological investigations.

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“…These pollutants can enter the human body in a variety of ways, resulting in adverse effects on human bodies. Damage to reproductive organs and infertility are among the harmful effects of air and water pollution (2)(3)(4)(5)(6)(7). Furthermore, many other infertility risk factors, such as cell phone radiation (8,9), strenuous exercise (10,11), and stress (12) have been identified and evaluated by researchers.…”

Section: Introductionmentioning

confidence: 99%

“…abnormal sperm, resulting in infertility (40,41). Other factors leading to adverse effects on both male and female fertility are exposure to intense light (42), microwave oven use (43), working in petrochemical industries (44,45), drinking chlorinated water or swimming in chlorinated swimming pools (6,46), using certain cosmetic products (47), consuming certain medical drugs (48), pesticide exposure (49), food preservatives (50), and prolonged standing (51).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Iranian College Students’ Awareness about Infertility Risk Factors

Alaee

Talaiekhozani²,

Ziaei³

et al. 2016

Jundishapur J Helath Sci

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Drinking-Water Disinfection By-products and Semen Quality: A Cross-Sectional Study in China

Cited by 58 publications

References 36 publications

Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis

Chronic exposures and male fertility: the impacts of environment, diet, and drug use on spermatogenesis

Overview of Disinfection By-products and Associated Health Effects

Evaluation of Iranian College Students’ Awareness about Infertility Risk Factors

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