1974
DOI: 10.1001/archpsyc.1974.01760140022003
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Drinking Problems in Adopted and Nonadopted Sons of Alcoholics

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Cited by 475 publications
(119 citation statements)
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“…Furthermore, genetic factors account for a large proportion of the increased risk in children of alcohol-dependent parents (Goodwin et al, 1974;Cloninger et al, 1981;Heath et al, 1997;Prescott and Kendler, 1999). In order to uncover markers that might identify those at increased risk for alcohol dependence, nonalcoholic offspring of alcohol-dependent persons have been investigated (Begleiter et al, 1984;Schuckit et al, 1987;Wand et al, 1994).…”
Section: Introductionmentioning
confidence: 99%
“…Furthermore, genetic factors account for a large proportion of the increased risk in children of alcohol-dependent parents (Goodwin et al, 1974;Cloninger et al, 1981;Heath et al, 1997;Prescott and Kendler, 1999). In order to uncover markers that might identify those at increased risk for alcohol dependence, nonalcoholic offspring of alcohol-dependent persons have been investigated (Begleiter et al, 1984;Schuckit et al, 1987;Wand et al, 1994).…”
Section: Introductionmentioning
confidence: 99%
“…Alcohol dependence has long been recognized as a familial disorder (Cotton, 1979), and genetic factors account for most of the increased risk in male (Goodwin et al, 1974;Prescott and Kendler, 1999) and female (Heath et al, 1997) children of alcohol-dependent parents. In search for underlying mechanisms, a number of studies investigated neurobiological alterations, most often in response to alcohol challenges, in offspring of alcoholics who have not yet developed alcohol-related disorders themselves (see for review Newlin and Thomson, 1990).…”
Section: Introductionmentioning
confidence: 99%
“…Firstdegree relatives of affected individuals are at a 2-to 8-fold increased risk for alcohol dependence (5,6). Adoption studies and twin studies have clarified that this familial clustering of alcohol dependence is attributable largely to genetic factors (7)(8)(9)(10)(11). In most recent studies, these heritable influences explain ≈50-80% of the individual differences in liability to alcohol dependence (12,13).…”
mentioning
confidence: 99%