ABSTRACT. Objective: The aim of this study was to describe older adults' 20-year alcohol-consumption and drinking-problem trajectories, identify baseline predictors of them, and determine whether older men and women differ on late-life drinking trajectory characteristics and predictors. Method: Two-group simultaneous latent growth modeling was used to describe the characteristics and baseline predictors of older community-residing men's (n = 399) and women's (n = 320) 20-year drinking trajectories. Chi-square difference tests of increment in fi t of latent growth models with and without gender invariance constraints were used to determine gender differences in drinking trajectory characteristics and predictors. Results: Unconditional quadratic growth models best described older individuals' within-individual, 20-year drinking trajectories, with alcohol consumption following an average pattern of delayed decline, and drinking problems an average pattern of decline followed by leveling off. On average, older men declined in alcohol consumption somewhat later than did older women. The best baseline predictors of more rapid decline in alcohol consumption and drinking problems were drinking variables indicative of heavier, more problematic alcohol use at late middle age. Conclusions: The course of alcohol consumption and drinking problems from late middle age onward is one of net decline, but this decline is neither swift nor invariable. Gender differences in the timing of decline in drinking suggest that ongoing monitoring of alcohol consumption may be especially important for older men. Further research is needed to identify factors known at late middle age that prospectively explain long-term change in late-life use of alcohol. (J. Stud Alcohol Drugs, 72, 308-321, 2011) (Ahlstrom, 2008). However, there is scarce evidence to support this view, and it has been drawn from studies with important design and analytic limitations. Furthermore, there has been almost no research to identify predictors of late-life decline in alcohol consumption and drinking problems. From a public health perspective, it is important to identify factors known at late middle age that prospectively infl uence older adults' subsequent drinking trajectories; this might inform development of interventions aimed at promoting healthier late-life drinking practices.This study builds on others' and our previous work in this area Moos et al., 2009Moos et al., , 2010 by using latent growth modeling to describe the 20-year drinking trajectories of men and women as they mature from late middle age (about age 55-65) through "later" old age (about age 75-85). In addition, it extends earlier research by determining whether key demographic, health-related, coping, and social context characteristics known at late middle age predict the level and shape of older individuals' subsequent 20-year drinking trajectories. Because so little is known about older women's drinking behavior as distinct from that of older men, this study also addresses whether gender...