Drinking and Vasopressin Release Following Central Injections of Angiotensin Ii in Minipigs

Thornton, Simon N.; Baldwin, B.A.; Forsling, Mary L.

doi:10.1113/expphysiol.1989.sp003257

Cited by 2 publications

(1 citation statement)

References 6 publications

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“…The role of oropharyngeal receptors in attenuating thirst has been extensively studied in both human [11,17,23,24,25,26] and animal models [27,28,29,30]. Figaro and Mack [11] showed that oropharyngeal receptors played an immediate role in inhibiting thirst, and thus, fluid intake, without influencing plasma osmolality when fluid was extracted immediately from the stomach after consumption.…”

Section: Discussionmentioning

confidence: 99%

The Utility of Thirst as a Measure of Hydration Status Following Exercise-Induced Dehydration

et al. 2019

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The purpose of this study was to examine the perception of thirst as a marker of hydration status following prolonged exercise in the heat. Twelve men (mean ± SD; age, 23 ± 4 y; body mass, 81.4 ± 9.9 kg; height, 182 ± 9 cm; body fat, 14.3% ± 4.7%) completed two 180 min bouts of exercise on a motorized treadmill in a hot environment (35.2 ± 0.6 °C; RH, 30.0 ± 5.4%), followed by a 60 min recovery period. Participants completed a euhydrated (EUH) and hypohydrated (HYPO) trial. During recovery, participants were randomly assigned to either fluid replacement (EUHFL and HYPOFL; 10 min ad libitum consumption) or no fluid replacement (EUHNF and HYPONF). Thirst was measured using both a nine-point scale and separate visual analog scales. The percent of body mass loss (%BML) was significantly greater immediately post exercise in HYPO (HYPOFL, 3.0% ± 1.2%; HYPONF, 2.6% ± 0.6%) compared to EUH (EUHFL, 0.2% ± 0.7%; EUHNF, 0.6% ± 0.5%) trials (p < 0.001). Following recovery, there were no differences in %BML between HYPOFL and HYPONF (p > 0.05) or between EUHFL and EUHNF (p > 0.05). Beginning at minute 5 during the recovery period, thirst perception was significantly greater in HYPONF than EUHFL, EUHNF, and HYPOFL (p < 0.05). A 10 min, ad libitum consumption of fluid post exercise when hypohydrated (%BML > 2%), negated differences in perception of thirst between euhydrated and hypohydrated trials. These results represent a limitation in the utility of thirst in guiding hydration practices.

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