2021
DOI: 10.1097/ftd.0000000000000807
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Dried Plasma Spots and Oral Fluid as Alternative Matrices for Therapeutic Drug Monitoring of Busulfan: Analytical Method Development and Clinical Evaluation

Abstract: Background: Busulfan (BU) is an alkylating agent with a narrow therapeutic index and high intraindividual pharmacokinetic variability used in conditioning therapy for hematopoietic stem cell transplantation. Monitoring BU exposure during high-dose conditioning regimens is recommended and positively impacts outcomes. We aimed to develop, validate, and apply a ultra-high-performance liquid chromatography-mass spectrometry (MS)/MS assay to measure BU concentrations in oral fluid and dried plasma spots (DPS) as al… Show more

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Cited by 4 publications
(3 citation statements)
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References 24 publications
(63 reference statements)
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“…[1][2][3] The most important, as well as the most studied and widely applied DMS, [4][5][6][7] is the dried blood spots (DBS) technique, described for the first time by Guthrie and Susi in 1963 and used in neonatal screening for the diagnosis of congenital phenylketonuria. 8 In the following years, the sampling of biological matrices on paper supports was used on multiple body fluids, such as plasma (DPS), 9,10 urine (DUS), 11,12 saliva, 13 tears, 14 breast milk, 15 synovial fluid, 16 cerebrospinal fluid (CSF), 17 and amniotic fluid. 18 This diffusion is well explained by highlighting the numerous advantages that the use of DMS for laboratory analysis entails: ease of sampling, especially in case of blood; simplicity in transport and storage, being suitable to be kept at room temperature even for long periods of time; improvement in the quality of life of subjects suffering from chronic diseases who must undergo periodical analyses; and suitability to a multitude of different analytical approaches.…”
Section: Introductionmentioning
confidence: 99%
“…[1][2][3] The most important, as well as the most studied and widely applied DMS, [4][5][6][7] is the dried blood spots (DBS) technique, described for the first time by Guthrie and Susi in 1963 and used in neonatal screening for the diagnosis of congenital phenylketonuria. 8 In the following years, the sampling of biological matrices on paper supports was used on multiple body fluids, such as plasma (DPS), 9,10 urine (DUS), 11,12 saliva, 13 tears, 14 breast milk, 15 synovial fluid, 16 cerebrospinal fluid (CSF), 17 and amniotic fluid. 18 This diffusion is well explained by highlighting the numerous advantages that the use of DMS for laboratory analysis entails: ease of sampling, especially in case of blood; simplicity in transport and storage, being suitable to be kept at room temperature even for long periods of time; improvement in the quality of life of subjects suffering from chronic diseases who must undergo periodical analyses; and suitability to a multitude of different analytical approaches.…”
Section: Introductionmentioning
confidence: 99%
“…15 This Special Issue also nicely illustrates several drug classes for whom TDM and particularly microsampling-assisted TDM are important to help guide therapy: immunosuppressants, anticonvulsants, antibiotics, and anticancer drugs. [8][9][10][11][22][23][24] The review by Moorthy et al in this Special Issue emphasizes the key advantage associated with microsampling, that is, the fact that it only requires the collection of minimal amounts of blood. This renders it a well-suited, patient-centric approach for pharmacokinetic studies in children where the amount of blood that can be collected may be limited.…”
mentioning
confidence: 99%
“…As is evident from the contributions of Granzotto et al and Mukai et al, the use of dried microsamples may facilitate sampling and aid logistics. 23,24 This has been exemplified for busulfan and a set of tyrosine kinase inhibitors, which were determined from dried plasma spots generated by application on filter paper. Such approaches that use dried samples aid in transportation and improve the stability of the samples, which can be of special relevance to developing countries, where specialized transportation of samples from a clinical (eg, transplantation) site to an analytical site performing the actual TDM may not be easily available.…”
mentioning
confidence: 99%