DRG Explant Model: Elucidating Mechanisms of Oxaliplatin-Induced Peripheral Neuropathy and Identifying Potential Therapeutic Targets
Junwei Du,
Leland C. Sudlow,
Igor D. Luzhansky
et al.
Abstract:Oxaliplatin triggered chemotherapy induced peripheral neuropathy (CIPN) is a common and debilitating side effect of cancer treatment which limits the efficacy of chemotherapy and negatively impacts patients quality of life dramatically. For better understanding the mechanisms of CIPN and screen for potential therapeutic targets, it is critical to have reliablein vitroassays that effectively mirror the neuropathyin vivo. In this study, we established a dorsal root ganglia (DRG) explant model. This model display… Show more
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