Dressings produced from PVA nanofibers containing chloramphenicol

Fraga, Gabriel Nardi; Dragunski, Douglas Cardoso; Vilsinski, Bruno H.; Azevedo, Camila Kauany da Silva; Wiggers, Helton José; Faria, Maria Graciela Iecher; Caetano, Josiane; Costa, Marcella Ribeiro da; Zanuto, Vitor Santaella; Rossin, Ariane Regina Souza; Gibin, Mariana Sversut

doi:10.1016/j.colsurfa.2023.131760

Cited by 6 publications

(2 citation statements)

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“…This feature contributes a lot to maintaining structural moisture, which helps remove the film from the injured skin without damaging it [ 1 ]. On the other hand, water absorption can lead the fibre to swell, promoting a decrease in pores and reducing the water vapor permeation capacity [ 56 ]. Furthermore, the low WVTR values may be related to the low porosity of the films [ 57 ], demonstrated by scanning electron microscopy (SEM) ( Figure 4 ).…”

Section: Resultsmentioning

confidence: 99%

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Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions

et al. 2023

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Natural products can be used as complements or as alternatives to synthetic drugs. Eugenia uniflora and Tropaeolum majus are natives of Brazil and have antimicrobial, anti-inflammatory, and antioxidant activities. This study aimed to develop a film-forming system (FFS) loaded with plant extracts with the potential for treating microbial infections. E. uniflora and T. majus leaf extracts were prepared and characterized, and the individual and combined antioxidant and antimicrobial activities were evaluated. The FFS was developed with different concentrations of polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) and analyzed for physicochemical characteristics. The combination of extracts showed a superior antioxidant effect compared to the individual extracts, justifying the use of the blend. FFS prepared with 4.5% PVA, 4.5% PVP, 7.81% E. uniflora extract, and 3.90% T. majus extract was adhesive, lacked scale formation, presented good malleability, and had a suitable pH for topical application. In addition, the viscosity at rest was satisfactory for maintaining stability; water solubility was adequate; skin permeation was low; and the antimicrobial effect was superior to that of the individual extracts. Therefore, the developed FFS is promising for the differentiated treatment of skin lesions through topical application.

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Section: Resultsmentioning

confidence: 99%

“…7301, Aurora, IL, USA). For each sample, the assay was performed in triplicate, and the average of the evaluation parameters was obtained [ 56 ].…”

Section: Methodsmentioning

confidence: 99%