Dressings and topical agents containing hyaluronic acid for chronic wound healing

Self-Adhesive, Strong Antifouling, and Mechanically Reinforced Methacrylate Hyaluronic Acid Cross-Linked Carboxybetaine Zwitterionic Hydrogels

“…Characterizations of HA-CB Hydrogels. 1 H NMR spectra of HA, HAGMA, and CBMAA in D 2 O with TMS were analyzed by an AVANCE III HD 400 MHz NMR spectrometer (Bruker, Germany). FTIR spectra of HAGMA, CBMAA, and the lyophilized hydrogel samples were recorded employing a Nicolet is50 spectrometer (Thermo Fisher, USA) in the range of 400−4000 cm −1 .…”

“…Hydrogels of natural and synthetic polymers that facilitate wound healing are unrivaled candidates for wound dressings. Hyaluronic acid, a natural linear polysaccharide existing in the extracellular matrix, can conduce to reducing inflammatory cell infiltration and promoting the formation of blood vessels, thus improving skin regeneration. − Zwitterionic polymer hydrogels are novel synthetic materials with a strong hydration effect that can promote wound closure and angiogenesis, rapid reconstruction of the extracellular matrix (ECM), and regulation of macrophage polarization to reduce inflammatory responses. − Carboxybetaine (CB) and sulfobetaine (SB) are common zwitterionic groups with similar electroneutral structure, and carboxybetaine zwitterionic polymer (PCB) hydrogels could promote skin wound healing more efficiently than sulfobetaione zwitterionic polymer (PSB) hydrogels for their disparate cationic and anionic groups . Although hyaluronic acid (HA) hydrogels and PCB hydrogels possessed eminent advantages as wound dressings, the crux of lacking satisfying mechanical strengths to adapt to limb movement and provide wound protection was still pendent.…”