DRESS syndrome induit par la téicoplanine

Loussaïef, C.; Kooli, I.; Fradj, Nadia Ben; Brahim, H. Ben; Aouam, A.; Toumi, A.; Aouam, Karim; Chakroun, M.

doi:10.1016/j.reval.2015.01.045

Cited by 2 publications

(1 citation statement)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In regard to delayed onset of signs and symptoms including skin rash (more than 50% of body surface area), fever (more than 38.5 °C), and enlarged lymph node (more than 1 cm in two sites), DRESS was highly suspected. These findings are in concordance with previous reports of teicoplanin-induced DRESS [3, 4, 6]. Additional work-up was performed to evaluate hematological abnormalities and organ involvement, which revealed leukocytosis with eosinophilia and liver involvement.…”

Section: Discussionsupporting

confidence: 91%

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) with Teicoplanin: A Case Report

Ebrahimpour

Mohammadi

Gholami

2016

Drug Saf - Case Rep

View full text Add to dashboard Cite

Intramuscular teicoplanin (400 mg every 12 h for three doses, then 400 mg daily, intramuscularly) was prescribed for a 37-year-old woman with presumptive diagnosis of cellulitis. On the 14th day of treatment, she developed generalized maculopapular rash, accompanied by fever, wheezing, shortening of breath, and lymphadenopathy. Lab tests revealed abnormal liver enzymes, leukocytosis, and eosinophilia. The treatment was interrupted with suspicion of drug reaction. Fever subsided after 48 h. Skin eruption and respiratory symptoms began to resolve within 2 weeks. The follow-up lab tests performed 1 month later indicated resolution of liver dysfunction. With respect to delayed onset of symptoms including fever, generalized rash, lymphadenopathy, and organ involvement, drug reaction with eosinophilia and systemic symptoms (DRESS) was highly suspected. The causality was evaluated by conventional scoring systems. The reaction was rated as probable (score = 5) according to RegiSCAR and possible (score = 5) based on Kardaun et al.’s scoring system. However, DRESS was not confirmed by the Japanese group’s criteria for diagnosis of DRESS/drug-induced hypersensitivity syndrome (DIHS).

show abstract

Section: Discussionsupporting

confidence: 91%