DRESS (Drug Rash with Eosinophilia and SystemicSypmtoms) Syndrome, solid organ involvement, skin immunity, hematological involvement is the drug reaction. If not treated, it may be mortal. The most common drugs are aromatic anticonvulsants. In this study, we present a rare case of DRESS syndrome with diagnosis of meningitis. Early diagnosis and treatment are important because of the systemic involvement and mortality.