Dramatic Cytokine Storm Reversal with an Over the Counter NMN Cocktail

Huizenga, Robert

doi:10.2139/ssrn.3581388

Cited by 1 publication

(2 citation statements)

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“…If the primary pathology is competition for depleted NAD + stores, the most rational intervention would be to increase NAD + supply. The leading candidate for investigation for treatment of sepsis, including COVID‐19, should therefore be nicotinamide (Vitamin B3) and related compounds, in agreement with other authors [20,77,80–85]. Indeed, in animal models, vitamin B3 ameliorates polymicrobial sepsis [86], lung ischaemia–reperfusion injury [87] or experimentally induced lung fibrosis [88].…”

Section: Novel Therapies For Sepsismentioning

confidence: 63%

“…Nicotinamide mononucleotide may have superior properties to nicotinamide in terms of its activity and side effect profile [102]. Importantly, dramatic clinical improvement was reported in a case series of nine severe COVID-19 patients treated with a nicotinamide mononucleotide cocktail (nicotinamide mononucleotide, betaine, sodium chloride and zinc sulfate) [85]. A third compound, nicotinamide riboside, has shown safety in human trials and ability to raise whole blood NAD + levels [104].…”

Section: Novel Therapies For Sepsismentioning

confidence: 99%

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Nicotinamide pathways as the root cause of sepsis – an evolutionary perspective on macrophage energetic shifts

Suchard

Savulescu

2021

The FEBS Journal

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Divergent pathways of macrophage metabolism occur during infection, notably switching between oxidative phosphorylation and aerobic glycolysis (Warburg-like metabolism). Concurrently, macrophages shift between alternate and classical activation. A key enzyme upregulated in alternatively activated macrophages is indoleamine 2,3-dioxygenase, which converts tryptophan to kynurenine for de novo synthesis of nicotinamide. Nicotinamide can be used to replenish cellular NAD + supplies. We hypothesize that an insufficient cellular NAD + supply is the root cause of metabolic shifts in macrophages. We assert that manipulation of nicotinamide pathways may correct deleterious immune responses. We propose evaluation of nicotinamide (Vitamin B3) and analogues, including isoniazid, nicotinamide mononucleotide and nicotinamide riboside, as potential therapy for infectious causes of sepsis, including COVID-19.

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