Drakenstein Child Health Study (DCHS): investigating determinants of early child development and cognition

Donald, Kirsten A.; Hoogenhout, Michelle; Plooy, Christopher P du; Wedderburn, Catherine J.; Nhapi, Raymond T; Barnett, Whitney; Hoffman, Nadia; Malcolm‐Smith, Susan; Zar, Heather J.; Stein, Dan J.

doi:10.1136/bmjpo-2018-000282

Cited by 57 publications

(57 citation statements)

References 37 publications

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“…14 Among these few in SSA, not all assessed childhood growth for more than a year and were mostly conducted in only five African countries. [15][16][17][18][19][20] Urban residence has been identified as a risk factor for intrauterine and postnatal malnutrition in Africa, the continent with the highest urbanisation rate in the world. 21,22 A number of the existing longitudinal data collection systems on the continent are located in rural areas with relatively homogenous populations, which are unsuitable for addressing the complex interaction of sociodemographic and economic factors with growth faltering and urbanisation.…”

Section: Introductionmentioning

confidence: 99%

Child Electronic Growth Monitoring System: An innovative and sustainable approach for establishing the Kaduna Infant Development (KID) Study in Nigeria

Kana

Ahmed

Ashiru

et al. 2020

Paediatric Perinatal Epid

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Background Developing countries bear the burden of childhood stunting but lack resources for cohort studies to develop preventive strategies. To enable future prospective studies, we designed and tested the Child Electronic Growth Monitoring System (CEGROMS) using a readily available electronic data capture platform, the Research Electronic Data Capture (REDCap). Objectives To demonstrate the feasibility of using CEGROMS for data collection for a pilot study for the Kaduna Infant Development (KID) Birth Cohort Study in Nigeria. Methods CEGROMS consists of the data capture form for growth monitoring, a central cloud server, electronic tablets, and desktop computer. We implemented the pilot study in 2017‐2019 at the Barau Dikko Teaching Hospital, Kaduna, Nigeria. Odds ratios (OR) and 95% confidence intervals (CI) were calculated for completeness of baseline data (relative to individuals with incomplete data) and completion of follow‐up at different time points (relative to individuals with no follow‐up visit) by the participant characteristics. Complete data were defined as date of birth, sex, and birthweight recorded at recruitment. Results Among 3152 infant records in CEGROMS, 2789 (88.5%) had complete data. Of these, 1905 (68.3%) had at least one follow‐up visit. The main determinants of data completeness were health facility delivery (OR 19.17, 95% CI 13.65, 26.92) and tertiary education (OR 3.54, 95% CI 2.69, 4.67). Follow‐up was greater for women with tertiary education (OR 1.33, 95% CI 1.06, 1.51 for at least one visit). Maternal education is associated with completeness and follow‐up (following adjustments for parity and employment). Conclusions The CEGROMS electronic data collection system enables complete and consistent data collection. The data will enable design of strategies to improve follow‐up in the future implementation of the birth cohort study.

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Section: Introductionmentioning

confidence: 99%

Child Electronic Growth Monitoring System: An innovative and sustainable approach for establishing the Kaduna Infant Development (KID) Study in Nigeria

Kana

Ahmed

Ashiru

et al. 2020

Paediatric Perinatal Epid

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“…any other congenital malformations as well as sets of twins and triplets were excluded from the study. In total, there were 1143 live births in the DCHS (see Donald et al, 2018). A subsample of the larger cohort completed the Bayley Scales of Infant Development-III (BSID-III) at 6 months (n = 260), whereas the full cohort was invited to participate at 24 months (n = 734) making a larger sample available.…”

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confidence: 99%

Prenatal alcohol exposure is associated with early motor, but not language development in a South African cohort

Hendricks

Malcolm‐Smith

Stein

et al. 2020

Acta Neuropsychiatr.

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Objective:To investigate the association of prenatal alcohol exposure (PAE) and early neurodevelopment in the first 2 years of life, adjusting for maternal socio-demographic and psychosocial factors, in the Drakenstein Child Health Study (DCHS), a South African birth cohort study.Methods:The DCHS comprises a population-based birth cohort of 1143 children, of which a subsample completed the Bayley Scales of Infant Development-III (BSID-III) at 6 (n = 260) and 24 months of age (n = 734). A subset of alcohol-exposed and -unexposed children was included in this analysis at age 6 (n = 52 exposed; n = 104 unexposed) and 24 months (n = 92 exposed; n = 184 unexposed). Multiple hierarchical regression was used to explore the associations of PAE with motor and language development.Results:PAE was significantly associated with decreased gross motor [odds ratio (OR) = 0.16, 95% confidence interval (CI) = 0.06–0.44, p = 0.001] or fine motor (OR = 0.16, 95% CI = 0.06–0.46, p = 0.001) functioning after adjusting for maternal socio-demographic and psychosocial factors at 6 months of age only. No significant effects were found in either receptive or expressive communication and cognitive outcomes at either time points.Conclusion:PAE has potentially important consequences for motor development in the first 2 years of life, a period during which the most rapid growth and maturation occur. These findings highlight the importance of identifying high-risk families in order to provide preventive interventions, particularly in antenatal clinics and early intervention services.

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“…Pregnant women were recruited at 20-28 weeks' gestation from two primary care clinics in the Drakenstein sub-district in Paarl, Western Cape, South Africaone (TC Newman) serves a predominantly Mixed ancestry community; while the other (Mbekweni) serves primarily a Black/African ancestry community. Within the DCHS, mothers are followed throughout pregnancy and childbirth until the index child is at least 5 years old [16][17][18] . General inclusion and exclusion criteria for the DCHS are described fully elsewhere 17 .…”

Section: Participantsmentioning

confidence: 99%

“…There is also a paucity of existing literature exploring maternal psychosocial predictors of offspring gestational EA acceleration, particularly in LMICs. This analysis was nested within the Drakenstein Child Health Study (DCHS), an ongoing, interdisciplinary, longitudinal birth cohort study investigating determinants of maternal-child health in a poor, peri-urban South African community [16][17][18] . We have previously reported a high burden of maternal psychosocial risk factors (eg.…”

Section: Introductionmentioning

confidence: 99%

Maternal psychosocial risk factors and offspring gestational epigenetic age acceleration in a South African birth cohort study

Koen

Jones

Nhapi

et al. 2018

Preprint

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Epigenetic age (EA) acceleration is associated with higher risk of chronic disease and mortality in adults. However, little is known about whether and how in utero exposures might shape gestational EA acceleration at birth. We aimed to explore associations between maternal psychosocial risk factors and offspring gestational EA acceleration at birth in a South African birth cohort studythe Drakenstein Child Health Study. Maternal psychosocial risk factors included trauma/stressor exposure; posttraumatic stress disorder (PTSD); depression, psychological distress; and alcohol/tobacco use. Offspring gestational EA acceleration at birth was calculated using an epigenetic clock previously devised for neonates. Bivariate linear regression was used to explore unadjusted associations between maternal risk factors and offspring gestational EA acceleration at birth. A stepwise regression method was then used to determine the best multivariable model for adjusted associations. Data from 272 maternal-offspring dyads were included in the current analysis.In the stepwise regression model, maternal trauma exposure (β=7.92; p<0.01) or PTSD (β=7.46; p<0.01) were significantly associated with offspring gestational EA acceleration at birth, controlling for ethnicity, offspring sex, head circumference at birth, maternal HIV status, and prenatal tobacco or alcohol use. In site-stratified models, these associations retained statistical significance and direction of effect. Maternal trauma exposure or PTSD may thus be associated with offspring gestational EA acceleration at birth. Given the novelty of this preliminary finding, and its potential translational relevance, further studies to delineate underlying biological pathways and to explore clinical implications of EA acceleration are warranted.

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Drakenstein Child Health Study (DCHS): investigating determinants of early child development and cognition

Cited by 57 publications

References 37 publications

Child Electronic Growth Monitoring System: An innovative and sustainable approach for establishing the Kaduna Infant Development (KID) Study in Nigeria

Child Electronic Growth Monitoring System: An innovative and sustainable approach for establishing the Kaduna Infant Development (KID) Study in Nigeria

Prenatal alcohol exposure is associated with early motor, but not language development in a South African cohort

Maternal psychosocial risk factors and offspring gestational epigenetic age acceleration in a South African birth cohort study

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