“…SRSF6 activity is at least in part controlled via phosphorylation by the dual specificity kinases CLK1 and DYRK1a (Hara et al, 2013; Yin et al, 2012), which activates SRSF6 shuttling between the cytoplasm and the nucleus (Sapra et al, 2009). SRSF6 abundance has been repeatedly associated with cancer, liver disease, and diabetes (Jensen et al, 2014; Juan-Mateu et al, 2018; Li et al, 2021) and recent work has identified several roles for SRSF6 in mitochondrial function and cell death. For example, loss of SRSF6 decreases mitochondrial respiration, leading to increased cellular apoptosis in human endoC-BH1 endothelial cells, likely via alternative splicing of cell death factors like Bim , Bax , Diablo , and Bclaf1 (Juan-Mateu et al, 2018).…”