Draft Genome Sequence of the Fluconazole-Resistant Candida palmioleophila Clinical Isolate CBS 18098

Lavergne, Rose‐Anne; Barbier, Paul; Mobuchon, Lenha; Banerjee, Atanu; Prasad, Rajendra; Morio, Florent

doi:10.1007/s11046-022-00682-1

Cited by 1 publication

(5 citation statements)

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“…Thus, these findings collectively suggested that the resistance of C. palmioleophila to antifungal medication should not be ignored. Another study confirmed the presence of fluconazole-resistant C. palmioleophila infection ( Lavergne et al, 2023 ). In our study, genomic analysis showed that CDR1, MDR1 and other homologous genes related to azole resistance of clinically isolated C. palmioleophila.…”

Section: Discussionmentioning

confidence: 74%

“…The BUSCO integrity of the assembled genome was 97.7%. Additional details, such as the comparison of C.-palmioleophila -associated genomic information with that obtained in another study ( Lavergne et al, 2023 ), are provided in Table 2 .…”

Section: Resultsmentioning

confidence: 99%

“…C. palmioleophila belongs to the order Saccharomycetales, the family Debaryomycetaceae , and the clade Candida glaebosa . C. palmioleophila are rare fungi that have been reported to cause an increasing number of human infections ( Mroczynska and Brillowska-Dabrowska, 2019 ; Stavrou et al, 2019 ; Casagrande Pierantoni et al, 2020 ; Lavergne et al, 2023 ). In this study, we reported a rare case of infection with C. palmioleophila.…”

Section: Discussionmentioning

confidence: 99%

“…In 1999, C. palmioleophila was reported as a human pathogen causing intravenous catheter-associated fungemia ( Sugita et al, 1999 ). In recent years, the incidence of C. palmioleophila infections has risen, and is often associated with drug resistance ( Datta et al, 2015 ; Mroczynska and Brillowska-Dabrowska, 2019 ; Casagrande Pierantoni et al, 2020 ; Lavergne et al, 2023 ). In 2018, C. palmioleophila was isolated for the first time in China and showed resistance to fluconazole ( Xiao et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

“…At presence, little known about the genetic relationship between C. palmioleophila and C. famata or C. guilliermondii, as well as common pathogenic fungi. Although the draft genome sequence of C. palmioleophila has been published in 2023 ( Lavergne et al, 2023 ), the genetic evolutionary characteristics of C. palmioleophila are still lacking. In addition, the pathogenic genes and drug resistant genes of C. palmioleophila need to be fully explored at the genomic level.…”

Section: Introductionmentioning

confidence: 99%

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The first rare case of Candida palmioleophila infection reported in China and its genomic evolution in a human host environment

Chu

et al. 2023

Front. Microbiol.

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IntroductionCandida palmioleophila is a rare human pathogenic fungus, which has been poorly characterized at the genome level. In this study, we reported the first fatal case of C. palmioleophila infection in China and investigate the microevolution of C. palmioleophila in the human host environment.MethodsA series of C. palmioleophila stains were collected from the patient at different time points for routine microbial and drug sensitivity testing. The first C. palmioleophila isolate 07202534 was identified by de novo whole genome sequencing. The in vitro and in vivo genetic evolutionary characteristics of C. palmioleophila were discussed based on the analysis of bioinformatics data.ResultsThe six C. palmioleophila isolates displayed dose-dependent sensitivity to fluconazole. The C. palmioleophila genome contained homologous genes such as CDR1 and MDR1, which were recognized to be related to azole resistance. In addition, amino acid variation was detected at F105L and other important sites of ERG11. In addition, the mean divergence time between C. palmioleophila and Scheffersomyces stipites CBS 6054 was 406.04 million years, indicating that C. palmioleophila originated earlier than its closest relative. In addition, the six strains of C. palmioleophila isolated form the patient had higher homology and fewer mutation sites, which indicated the stability in C. palmioleophila genome. We also found that C. palmioleophila had a wide natural niche and may evolve slowly.DiscussionWe believe that this study will contribute to improve our understanding of the genetic evolution, pathogenicity, and drug resistance of C. palmioleophila and will aid in the prevention and control of its spread.

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Section: Discussionmentioning

confidence: 74%

Section: Resultsmentioning

confidence: 99%