Draft Genome Sequence of Kerstersia gyiorum CG1, Isolated from a Leg Ulcer

Greninger, Alexander L.; Kozyreva, Varvara K.; Truong, Chau-Linda; Longoria, Rose; Chaturvedi, Vishnu

doi:10.1128/genomea.01036-15

Cited by 4 publications

(3 citation statements)

References 10 publications

(9 reference statements)

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“…Genome sequencing of K. gyiorum has been reported previously, 27 , 31 which laid the foundation for further research. In previous reports, smoking, drinking alcohol, obesity, and unhealthy residential environments were considered risk factors for infection.…”

Section: Discussionmentioning

confidence: 99%

Kerstersia gyiorum isolated for the first time from two patients with neurodegenerative disease: report of two unusual cases and a review of the literature

et al. 2023

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With the development of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) and 16S ribosomal RNA (rRNA) gene sequencing, increasing numbers of new microorganisms are being discovered. In this report, Kerstersia gyiorum was isolated for the first time from the sputum of two elderly patients with neurodegenerative disease, and integrated traditional Chinese and Western medicine was used for treatment. The bacteria’s growth characteristics, biochemical reaction characteristics, sensitivity to antibiotics, and the patients’ treatment are described, with a review of previous reports.

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Section: Discussionmentioning

confidence: 99%

Kerstersia gyiorum isolated for the first time from two patients with neurodegenerative disease: report of two unusual cases and a review of the literature

et al. 2023

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“…K. gyiorum appears as a human pathogen described in the literature reviewed in nine occasions, being isolated from urine samples [9], ulcers [10,11] sputum [12] and causing chronic otitis in five cases [2][3][4][5].…”

Section: Discussionmentioning

confidence: 99%

Kerstersia Gyiorum causing Chronic Otitis Media: Where a Quinolone Does not Work

Manuel¹,

Lechuz²

2017

J Infec Dis Treat

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Chronic otitis media (COM) is an inflammatory disease which affects the mucosal and bone structures of the medium ear, insidiously, slowly progressive, prone to persist and to produce severe sequelae. Staphylococcus aureus following by gram negative bacillus as Proteus spp., Klebsiella spp., Escherichia spp. and Haemophilus influenza are common pathogens causing COM. Recently some cases of COM produced by less known bacteria have been described. This is the case of the genus Kerstersia which has emerged in the literature causing bacteremia and urinary infection, as well as a causative pathogen of chronic otitis.We have reviewed five cases as well as our own experience with an 88-year-old man transferred to our hospital suffering from persistent otorrhea, finally diagnosed as COM caused by Kerstersia gyiorum resistant to quinolones. Kerstersia genus belongs to the family Alcaligenaceae. A sample from the ear of our patient was taken and gram-negative rods were observed in the Gram stain. After incubation for 24 h, in all media, abundant slightly convex colonies with extended edges, colorful, were isolated and identified by MALDI-TOF (matrixassisted laser desorption ionization time-of-flight) Biotyper 3.1 as Kerstersia gyiorum (score of 2.3. K. gyiorum identification was confirmed by sequencing of the rRNA 16S gene and comparing of the sequence obtained with those deposited in GenBank with the NCBI BLASTn algorithm. Our case would be the third case resistant to quinolones reported in the literature.

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“…Though a draft genome of K . gyiorum was announced by Greninger et al [15], a comprehensive genome analysis of this organism is still not available to date. For this study, we presented a complete genome sequence of recently identified isolate K .…”

Section: Introductionmentioning

confidence: 99%

Genomic characterization of Kerstersia gyiorum SWMUKG01, an isolate from a patient with respiratory infection in China

et al. 2019

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Background The Gram-negative bacterium Kerstersia gyiorum , a potential etiological agent of clinical infections, was isolated from several human patients presenting clinical symptoms. Its significance as a possible pathogen has been previously overlooked as no disease has thus far been definitively associated with this bacterium. To better understand how the organism contributes to the infectious disease, we determined the complete genomic sequence of K . gyiorum SWMUKG01, the first clinical isolate from southwest China. Results The genomic data obtained displayed a single circular chromosome of 3, 945, 801 base pairs in length, which contains 3, 441 protein-coding genes, 55 tRNA genes and 9 rRNA genes. Analysis on the full spectrum of protein coding genes for cellular structures, two-component regulatory systems and iron uptake pathways that may be important for the success of the bacterial survival, colonization and establishment in the host conferred new insights into the virulence characteristics of K . gyiorum . Phylogenomic comparisons with Alcaligenaceae species indicated that K . gyiorum SWMUKG01 had a close evolutionary relationships with Alcaligenes aquatilis and Alcaligenes faecalis . Conclusions The comprehensive analysis presented in this work determinates for the first time a complete genome sequence of K . gyiorum , which is expected to provide useful information for subsequent studies on pathogenesis of this species.

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Draft Genome Sequence of Kerstersia gyiorum CG1, Isolated from a Leg Ulcer

Cited by 4 publications

References 10 publications

Kerstersia gyiorum isolated for the first time from two patients with neurodegenerative disease: report of two unusual cases and a review of the literature

Kerstersia gyiorum isolated for the first time from two patients with neurodegenerative disease: report of two unusual cases and a review of the literature

Kerstersia Gyiorum causing Chronic Otitis Media: Where a Quinolone Does not Work

Genomic characterization of Kerstersia gyiorum SWMUKG01, an isolate from a patient with respiratory infection in China

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