Draft genome sequence of Coxiella burnetii Dog Utad, a strain isolated from a dog-related outbreak of Q fever

D'Amato, Felicetta; Million, Matthieu; Edouard, Sophie; Delerce, Jérémy; Robert, Caroline; Marrie, Tom; Raoult, Didier

doi:10.1002/nmi2.55

Cited by 11 publications

(7 citation statements)

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“…In these countries some hyperendemic foci also can be identified, as in Martigues, a city in southeastern France, where the Q fever incidence rate reaches 34.5/100,000 inhabitants due to dissemination of spores by the local mistral wind from sheep herds breeding in the local plains (46). Small outbreaks (especially familial outbreaks) may occur after exposure to a common source, such as C. burnetiiinfected parturient pets such as dogs or cats (47,48). Also, an anecdotal outbreak was recently reported in the United States in five patients, due to intramuscular injection of fetal sheep cells by a German doctor practicing "live cell therapy," a xenotransplantation practice with no published evidence of efficacy (49).…”

Section: Epidemiological Characteristics Of C Burnetii Infection Ovementioning

confidence: 99%

“…Since 2003, six new whole genomes of C. burnetii have become available in GenBank (142)(143)(144). Sixteen incomplete genomes can also be found (27,47,(145)(146)(147)(148)(149)(150). In 2009, Beare et al performed a comparative genomic analysis of four strains and found a total of 125 pseudogenes, of which 65 were highly conserved, and 8 IS families (142).…”

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

“…DOG UTAD was plasmidless and showed 70 mutations, of which 47 were nonsynonymous compared to Q212. Both strains belong to the same genotype, MST 21, which has been isolated only in Canada to date (47).…”

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

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From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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Coxiella burnetii is the agent of Q fever, or "query fever," a zoonosis first described in Australia in 1937. Since this first description, knowledge about this pathogen and its associated infections has increased dramatically. We review here all the progress made over the last 20 years on this topic. C. burnetii is classically a strict intracellular, Gram-negative bacterium. However, a major step in the characterization of this pathogen was achieved by the establishment of its axenic culture. C. burnetii infects a wide range of animals, from arthropods to humans. The genetic determinants of virulence are now better known, thanks to the achievement of determining the genome sequences of several strains of this species and comparative genomic analyses. Q fever can be found worldwide, but the epidemiological features of this disease vary according to the geographic area considered, including situations where it is endemic or hyperendemic, and the occurrence of large epidemic outbreaks. In recent years, a major breakthrough in the understanding of the natural history of human infection with C. burnetii was the breaking of the old dichotomy between "acute" and "chronic" Q fever. The clinical presentation of C. burnetii infection depends on both the virulence of the infecting C. burnetii strain and specific risks factors in the infected patient. Moreover, no persistent infection can exist without a focus of infection. This paradigm change should allow better diagnosis and management of primary infection and long-term complications in patients with C. burnetii infection.

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Section: Epidemiological Characteristics Of C Burnetii Infection Ovementioning

confidence: 99%

Section: Comparative Genomics and Pangenomic Analysismentioning

confidence: 99%

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From Q Fever to Coxiella burnetii Infection: a Paradigm Change

et al. 2017

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“…Infection with C. burnetii in humans is usually asymptomatic but it may trigger acute and chronic clinical manifestations. C. burnetii is also one of main pathogens causing reproductive losses in livestock ( 1 ) and reproductive failure in pets ( 2 , 3 ) and wildlife ( 4 – 7 ). Clinical signs of Q fever in domestic ruminants are diverse; it has been associated with sporadic cases of abortion, premature delivery, stillbirth, and weak offspring in cattle, sheep, and goats, but epidemics with increased reproductive failure have been reported for sheep and goats mainly ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Long-Term Dynamics of Coxiella burnetii in Farmed Red Deer (Cervus elaphus)

González‐Barrio

Fernández-de-Mera

Ortíz³

et al. 2015

Front. Vet. Sci.

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Several aspects of the dynamics of Coxiella burnetii that are relevant for the implementation of control strategies in ruminant herds with endemic Q fever are unknown. We designed a longitudinal study to monitor the dynamics of exposure to C. burnetii in a red deer herd with endemic infection in order to allow the design of Q fever-specific control approaches. Other relevant aspects of the dynamics of C. burnetii – the effect of herd immune status, age, season, and early infection on exposure, the average half-life of antibodies, the presence and duration of maternal humoral immunity, and the age of first exposure – were analyzed. The dynamics of C. burnetii in deer herds seems to be modulated by host herd and host individual factors and by particular host life-history traits. Red deer females become exposed to C. burnetii at the beginning of their second year since maternal antibodies protect them after birth and during the main pathogen shedding season – at the end of spring-early summer. Infection pressure varies between years, probably associated with herd immunity effects, determining inter-annual variation in the risk of exposure. These results suggest that any strategy applied to control C. burnetii in deer herds should be designed to induce immunity in their first year of life immediately after losing maternal antibodies. The short average life of C. burnetii antibodies suggests that any protection based on humoral immunity would require re-vaccination every 6 months.

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“…12 In canine species, the epidemiological role of C. burnetii infection is still debated; however, seropositivity has been reported in dogs, and human outbreaks associated with parturient bitches have been described. 13,14 C. burnetii DNA has also been recently detected in 4 of 54 canine placentas originating from aborting animals in The Netherlands. 15 Leptospirosis is a worldwide re-emerging disease caused by a gram-negative bacterium of the genus Leptospira.…”

Section: Introductionmentioning

confidence: 99%

Retrospective Biomolecular Investigation of Coxiella burnetii and Leptospira spp. DNA in Cases of Abortion, Stillbirth and Neonatal Mortality in Dogs and Cats

Stefanetti

Compagnone

Chiara

et al. 2018

Topics in Companion Animal Medicine

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A B S T R A C T Abortion and neonatal mortality are events that can occur in breeding bitches and queens. It has been reported that up to 55% and 33% of these cases remain without a known cause, respectively, in canine and feline pregnancies. Unusual abortigenic and potentially zoonotic agents, including Coxiella burnetii and Leptospira spp., may be involved in these cases. C. burnetii is able to cause reproductive disorders in cattle, sheep and goats, and cases of abortion have been observed in dogs and cats. Moreover, several outbreaks of C. burnetii infection in humans have been caused by delivering bitches and queens, and some of these animals experienced abortion. Leptospira interrogans sensu lato is able to cause abortion or stillbirth in several animal species and its abortigenic role has occasionally been described in bitches and queens. The aim of this study was to search for C. burnetii and Leptospira spp. DNA in a retrospective series of 103 cases of canine and feline abortion, stillbirth, and neonatal mortality submitted for the identification of possible infectious agents. One hundred and fifty-one specimens were tested using PCR assays and found negative for C. burnetii and Leptospira DNA. However, in 49 samples (47.6%) other infectious causes of abortion, stillbirth, and neonatal mortality were identified. These results showed that C. burnetii and Leptospira spp. are probably not common abortigenic agents or causes of neonatal deaths in dogs. However, given the potential abortigentic and zoonotic role of these agents, surveillance of canine and feline abortion, stillbirth, and neonatal mortality could be advisable for a systematic investigation of these events.

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Draft genome sequence of Coxiella burnetii Dog Utad, a strain isolated from a dog-related outbreak of Q fever

Cited by 11 publications

References 6 publications

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

From Q Fever to Coxiella burnetii Infection: a Paradigm Change

Long-Term Dynamics of Coxiella burnetii in Farmed Red Deer (Cervus elaphus)

Retrospective Biomolecular Investigation of Coxiella burnetii and Leptospira spp. DNA in Cases of Abortion, Stillbirth and Neonatal Mortality in Dogs and Cats

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