Draft Genome Sequence of an Isolate of Genotype VII Newcastle Disease Virus Isolated from an Outbreak in Fighting Cock in Peru

Fernández-Díaz, Manolo; Montalvan-Avalos, Angela; Isasi-Rivas, Gisela; Villanueva-Pérez, Doris; Quiñones-García, Stefany; Tataje-Lavanda, Luis; Rios-Matos, Dora; Lulo-Vargas, Milagros; Fernández-Sánchez, Manolo; Guevara-Sarmiento, Luis A.; Zimic, Mirko; Rojas-Neyra, Aldo; Calderón, Katherine

doi:10.1128/mra.01293-22

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Genotype VII is of special significance because it has been linked to a number of recent outbreaks in South America, the Middle East, Africa, and Asia ( 21 , 26 , 40 , 47 – 51 ). After decades of research and development aimed at creating the best possible ND vaccine, new concepts and improved formulations for vaccine generation are still needed ( 17 , 41 , 52 , 53 ).…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Expression of Chicken Granulocyte Monocyte Colony-Stimulating Factor and the Hemagglutinin-Neuraminidase Epitope of the Virulent Newcastle Disease Virus Genotype VII C22 Strain in a Functional Synthetic Recombinant Adenovirus as a Genotype-Matched Vaccine with Potential Antiviral Activity

Adam

Zhao

et al. 2023

Microbiol Spectr

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We studied the biological characterization of the developed functional synthetic recombinant adenoviruses, which showed a high degree of safety, thermostability, and genetic stability for up to 20 passages. It was demonstrated through both in vitro and in vivo testing that the immunogenicity of the proposed vaccine, which uses the T2A peptide from the Thosea asigna virus capsid protein supported by glycine and serine, helps with efficiency to generate a multicistronic vector, enables expression of two functional proteins in rAdv-ChGM-CSF-HN, and is superior to that of comparable vaccines.

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