DR7 and DQ2 are positively associated with immunoglobulin-E response to the main antigen of olive pollen (Ole e I) in allergic patients

Cárdaba, Blanca; Vilches, Carlos; Martín, Elena; Andrés, Belen de; Pozo, Victoria del; Hernández, Dolores; Gallardo, Soledad; Fernández, Julio César; Villalba, M; Rodrı́guez, Rosalı́a; Basomba, A.; Kreisler, M.; Palomino, Pilar; Lahoz, Carlos

doi:10.1016/0198-8859(93)90557-h

Cited by 43 publications

(37 citation statements)

References 21 publications

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“…These molecules play a pivotal role in the binding and presentation of antigenic peptides to T cells. A great deal of research has been performed in this field, and several associations with specific IgE antibody response and HLA class II polymorphisms have been described [6, 7, 8]. The T cell receptor α-chain locus is located on chromosome 14q11.2 which has been associated with specific IgE antibody response [9].…”

Section: Introductionmentioning

confidence: 99%

Allergy to <i>Dermatophagoides</i> in a Group of Spanish Gypsies: Genetic Restrictions

Cárdaba

Moffatt²,

Fernández³

et al. 2001

Int Arch Allergy Immunol

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Background: Spanish gypsies have traditionally lived as nomads, a reason why few epidemiological studies were done in this ethnic group. However, the high prevalence of asthmatic diseases demonstrated in a population residing in the North of Spain induces us to analyse whether it was due to the influence of genetic loci previously implicated in other population studies as causing the disorders. Methods: DRB1* and DQB1* HLA class II, TCR-Vα8.1, FcΕRI-β Rsa I exon 7 and intron 2, TNF-β (LTα-Nco I) and CD14, were tested for association with asthma and atopy by multiple regression analysis, in 5 families comprising 87 individuals. Results: Significant associations were found with DQB1*02 (p = 0.02) and DQB1*0301 (p = 0.008) and elevated levels of total serum IgE. A negative association (p = 0.02) was found between total serum IgE and DRB1*14. FcΕRI-β Rsa I-In2 allele 1 was associated with high levels of total serum IgE (p = 0.04). Levels of Der p 1 IgE antibodies were negatively associated with DRB1*11-DQB1*0301 (p = 0.007), and positively with TCR Vα-8 allele 1 (p = 0.04) and with FcΕRI-β Rsa I-In2 allele 1 (p = 0.009). Conclusions: Our results do not show any association between asthma and the genetic loci studied although they do suggest the existence of multiple genetic influences on the allergic response in these families.

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Section: Introductionmentioning

confidence: 99%

Allergy to <i>Dermatophagoides</i> in a Group of Spanish Gypsies: Genetic Restrictions

Cárdaba

Moffatt²,

Fernández³

et al. 2001

Int Arch Allergy Immunol

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“…The main objective of multiple investigations was to identify potential risk factors in the environment and to identify "allergy genes". Classically there were two main approaches for searching genes related with asthma/allergy diseases: analysis of candidate genes or genome-wide screening, looking for new disease loci or genes (Ober & Hofman., 2006, Risk et al, 1996, Cárdaba et al, 1993, Carlson et al, 2004, Vercelli, 2008. Population genetic studies like association studies and linkage analysis have played major roles in identification of several causative genes.…”

Section: Genetic and Genomic Studies In Allergymentioning

confidence: 99%

New Challenges for Old Diseases: The Impact of -Omics Technologies in the Understanding of Allergic Diseases

Cárdaba¹,

Aguerri²,

Calzada³

et al. 2012

Allergic Diseases - Highlights in the Clinic, Mechanisms and Treatment

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“…Genetic studies of an Ole e 1-sensitive population have shown that the specific response to the allergen is associated with the DR7 and DQ2 HLA class II antigens [45]. Ole e 1 IgG titers are positively correlated with HLA-DRB1*0701 and HLA-DQB1*0201 alleles, and DQB1*0201 was also found to be correlated with Ole e 1 IgE titers [45, 46].…”

Section: Structural Properties and Functional Roles Of Olive Pollen Amentioning

confidence: 99%

“…Ole e 1 IgG titers are positively correlated with HLA-DRB1*0701 and HLA-DQB1*0201 alleles, and DQB1*0201 was also found to be correlated with Ole e 1 IgE titers [45, 46]. In addition, it was demonstrated that IgE antibodies against Ole e 1 were associated with FcεRI-β [47].…”

Section: Structural Properties and Functional Roles Of Olive Pollen Amentioning

confidence: 99%

The Spectrum of Olive Pollen Allergens

Rodrı́guez

Villalba

Monsalve

et al. 2001

Int Arch Allergy Immunol

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Olive pollen is one of the most important causes of seasonal respiratory allergy in Mediterranean countries, where this tree is intensely cultivated. Among the high number of protein allergens detected in this pollen, 8 – Ole e 1 to Ole e 8 – have been isolated and characterized. Ole e 1 is the most frequent sensitizing agent, affecting more than 70% of the patients suffering of olive pollinosis, although others, such as Ole e 4 and Ole e 7, have also been shown to be major allergens. In this context, the prevalence of many olive pollen allergens seems to be dependent on the geographical area where the sensitized patients live. Some of the olive allergens have been revealed as members of known protein families: profilin (Ole e 2), Ca²⁺-binding proteins (Ole e 3 and Ole e 8), superoxide dismutase (Ole e 5) and lipid transfer protein (Ole e 7). No biological function has been demonstrated for Ole e 1, whereas Ole e 4 and Ole e 6 are new proteins without homology to known sequences from databases. cDNAs encoding for Ole e 1, Ole e 3 and Ole e 8 have been overproduced in heterologous systems. The recombinant products were correctly folded and exhibited the functional activities of the natural allergens. In addition to the Oleaceae family, other species, such as Gramineae or Betulaceae, contain pollen allergens structurally or immunologically related to those of the olive tree. This fact allows to detect and evaluate antigenic cross-reactivities involving olive allergens. The aim of this research is the development of new diagnostic tools for olive pollinosis and new approaches to improve the classical immunotherapy.

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DR7 and DQ2 are positively associated with immunoglobulin-E response to the main antigen of olive pollen (Ole e I) in allergic patients

Cited by 43 publications

References 21 publications

Allergy to <i>Dermatophagoides</i> in a Group of Spanish Gypsies: Genetic Restrictions

Allergy to <i>Dermatophagoides</i> in a Group of Spanish Gypsies: Genetic Restrictions

New Challenges for Old Diseases: The Impact of -Omics Technologies in the Understanding of Allergic Diseases

The Spectrum of Olive Pollen Allergens

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