Dr. Venkat S. Ram awarded Padmashri

An Improvement to the Preparation of Prasugrel Hydrochloride

“…8 Stepankova synthesised this compound from 2cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl methanesulfonate and 5,6,7,7a-tetrahydrothieno [3,2-c]pyridin-2(4H)-one hydrochloride. 9 Given the relatively low yield and unavoidable impurities (Scheme 2), [8][9][10][11][12] there is still room for improvement. We report here an improved synthetic route for the preparation of prasugrel hydrochloride.…”