Dr. Uhre et al. Reply:

Uhre, Valdemar; Uhre, Camilla Funch; Lønfeldt, Nicole Nadine; Pretzmann, Linea; Vangkilde, Signe; Plessen, Kerstin J.; Gluud, Christian; Jakobsen, Janus Christian; Pagsberg, Anne Katrine

doi:10.1016/j.jaac.2020.04.013

Cited by 4 publications

(3 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Response rates in the three trials were 50 to 72% for CBT versus 20 to 41% for PRT with an effect size of 0.3 reported in one of the studies [ 12 ]. However, these trials were at risk-of-bias due to unclear randomisation process, missing outcome data and, for one trial, deviations from the intended treatment [ 14 ]. Also, although one study found higher response rates and a faster decline in OCD severity with CBT compared to PRT, symptom reduction at end of treatment was comparable in the two groups [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial)

Pagsberg

Uhre

et al. 2022

BMC Psychiatry

Self Cite

View full text Add to dashboard Cite

Background Cognitive behavioural therapy (CBT) is the recommended first-line treatment for children and adolescents with obsessive-compulsive disorder (OCD), but evidence concerning treatment-specific benefits and harms compared with other interventions is limited. Furthermore, high risk-of-bias in most trials prevent firm conclusions regarding the efficacy of CBT. We investigate the benefits and harms of family-based CBT (FCBT) versus family-based psychoeducation and relaxation training (FPRT) in youth with OCD in a trial designed to reduce risk-of-bias. Methods This is an investigator-initiated, independently funded, single-centre, parallel group superiority randomised clinical trial (RCT). Outcome assessors, data managers, statisticians, and conclusion drawers are blinded. From child and adolescent mental health services we include patients aged 8–17 years with a primary OCD diagnosis and an entry score of ≥16 on the Children’s Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). We exclude patients with comorbid illness contraindicating trial participation; intelligence quotient < 70; or treatment with CBT, PRT, antidepressant or antipsychotic medication within the last 6 months prior to trial entry. Participants are randomised 1:1 to the experimental intervention (FCBT) versus the control intervention (FPRT) each consisting of 14 75-min sessions. All therapists deliver both interventions. Follow-up assessments occur in week 4, 8 and 16 (end-of-treatment). The primary outcome is OCD symptom severity assessed with CY-BOCS at end-of-trial. Secondary outcomes are quality-of-life and adverse events. Based on sample size estimation, a minimum of 128 participants (64 in each intervention group) are included. Discussion In our trial design we aim to reduce risk-of-bias, enhance generalisability, and broaden the outcome measures by: 1) conducting an investigator-initiated, independently funded RCT; 2) blinding investigators; 3) investigating a representative sample of OCD patients; 3) using an active control intervention (FPRT) to tease apart general and specific therapy effects; 4) using equal dosing of interventions and therapist supervision in both intervention groups; 5) having therapists perform both interventions decided by randomisation; 6) rating fidelity of both interventions; 7) assessing a broad range of benefits and harms with repeated measures. The primary study limitations are the risk of missing data and the inability to blind participants and therapists to the intervention. Trial registration ClinicalTrials.gov: NCT03595098, registered July 23, 2018.

show abstract

Section: Introductionmentioning

confidence: 99%

Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial)

Pagsberg

Uhre

et al. 2022

BMC Psychiatry

Self Cite

View full text Add to dashboard Cite

show abstract

“…While studies indicate lower response rates for PRT compared to CBT for youths with OCD (PRT: 20%–40%; CBT: 50%–72%) [ 2 , 25 , 26 ]. However, these studies did not monitor adverse events and were at high risk of bias due to unclear randomization and missing outcome data [ 11 , 27 ]. Thus, we wish to examine whether certain individual characteristics or circumstances are risk factors for experiencing adverse events and if PRT should be considered an alternative treatment option for certain youth with OCD.…”

Section: Introductionmentioning

confidence: 99%

Adverse events in cognitive behavioral therapy and relaxation training for children and adolescents with obsessive-compulsive disorder: A mixed methods study and analysis plan for the TECTO trial

Pretzmann

Christensen

et al. 2023

Contemporary Clinical Trials Communications

Self Cite

View full text Add to dashboard Cite

“…They claim that the methods of Uhre et al are questionable, their PRISMA-derived included trials have a narrow focus, their use of Grading of Recommendations Assessment Development and Evaluation criteria is inappropriate, and their findings therefore are flawed and misrepresent the evidence. In a spirited rebuttal and defense of their work, Uhre et al 3 respond to each criticism in turn, defending their work as a rigorous synthesis and analysis of the extant literature.…”

mentioning

confidence: 99%

When Science Challenges Our Long-Held Assumptions About the Robustness of Evidence for Standard of Care

Geller

Hosker

2020

Journal of the American Academy of Child & Adolescent Psych

View full text Add to dashboard Cite

Dr. Uhre et al. Reply:

Cited by 4 publications

References 24 publications

Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial)

Family-based cognitive behavioural therapy versus family-based relaxation therapy for obsessive-compulsive disorder in children and adolescents: protocol for a randomised clinical trial (the TECTO trial)

Adverse events in cognitive behavioral therapy and relaxation training for children and adolescents with obsessive-compulsive disorder: A mixed methods study and analysis plan for the TECTO trial

When Science Challenges Our Long-Held Assumptions About the Robustness of Evidence for Standard of Care

Contact Info

Product

Resources

About