Dr. Pincus replies

Pincus, Theodore

doi:10.3899/jrheum.081066

Cited by 2 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A notable feature of both our families and those reported previously is a complete lack of objective neurological abnormalities outside those produced directly by the choreic movements. Although intention tremor was noted by Pincus & Chutorian (1967), this was slight and neither in their patients nor in others have general abnormalities of incoordination or other cerebellar ahnormalities occurred.…”

Section: Discussionmentioning

confidence: 71%

“…The families reported here, and most previous reports, are compatible with auto-soma1 dominant inheritance, but reservations about this need to be stated. Male-to-male transmission is notably rare, being present only in the families of Pincus & Chutorian (1967) and possibly that of Sadjadpour & Amato (1973); it is absent from both the families reported here, and from the large kindred of Haerer et al (1967). Nevertheless, X-linked dominant inheritance is made improbable by the lack of an excess of affected females, by the apparently similar severity in the sexes, and by the fact that in Pincus & Chutorian's family transmission was not only from male to male but through an unaffected male.…”

Section: Mode Of Inheritancementioning

confidence: 99%

See 1 more Smart Citation

Benign hereditary chorea Clinical and genetic aspects

Harper

1978

Clinical Genetics

View full text Add to dashboard Cite

Five patients from two families in Wales are described who have a benign disorder characterized by lifelong, non‐progressive choreic movements, but without mental deterioration or other features of Huntington's disease. The clinical picture and natural history of this specific disorder are discussed, with particular emphasis on its distinction from Huntington's disease. Genetic data from previously reported kindreds are reviewed, and it is concluded that the disorder follows autosomal dominant inheritance, with reduced penetrance in the female. The importance is stressed of recognizing this disorder and not confusing it with Huntington's disease, if serious errors in prognosis and genetic counselling are to be avoided.

show abstract

Section: Discussionmentioning

confidence: 71%

Section: Mode Of Inheritancementioning

confidence: 99%

Benign hereditary chorea Clinical and genetic aspects

Harper

1978

Clinical Genetics

View full text Add to dashboard Cite

show abstract

“…Rheumatoid arthritis (RA) leads to destruction of cartilage and deformation of bones 4,5 . The injury of inflammation causes release of inflammatory mediators such as Tumor necrosis factor-α and Interlucin-1β.…”

Section: Introductionmentioning

confidence: 99%

Docking and 3D QSAR Studies on p38α MAP Kinase Inhibitors

Jatavath

Sivan

Yamini

et al. 2011

Journal of Chemistry

View full text Add to dashboard Cite

The p38 signaling cascade has emerged as an attractive target for the design of novel chemotherapeutic agents for the treatment of inflammatory diseases. Three dimensional quantitative structure- activity relationship (3D- QSAR) studies were performed on a series of 25, 2-aminothiazole analogs as inhibitors of p38α mitogen activated protein (MAP) kinase. The docking results provided a reliable conformational alignment scheme for the 3D-QSAR model. The 3D-QSAR model showed very good statistical results namely q2, r2and r2predvalues for both comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA). The CoMFA and CoMSIA models & docking results provided the most significant correlation of steric, electrostatic, hydrophobic,H-bond donor,H-bond acceptor fields with biological activities and the provided values were in good agreement with the experimental results. The information rendered from molecular modeling studies gave valuable clues to optimize the lead and design new potential inhibitors.

show abstract

Dr. Pincus replies

Cited by 2 publications

References 14 publications

Benign hereditary chorea Clinical and genetic aspects

Benign hereditary chorea Clinical and genetic aspects

Docking and 3D QSAR Studies on p38α MAP Kinase Inhibitors

Contact Info

Product

Resources

About