Dr. Feigelson Replies

Feigelson, Eugene B.

doi:10.1176/ajp.136.10.1350-a

Cited by 5 publications

(6 citation statements)

References 1 publication

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“…Although glucocorticoids have long been known to increase liver protein and RNA content, data relevant to their effects on proteolysis in different in i o and in itro experimental models are conflicting [40][41][42]. However, these hormones by themselves do not affect or even stimulate protein catabolism.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of liver RNA breakdown during acute inflammation in the rat

Saadane

Neveux

Feldmann

et al. 1996

Biochemical Journal

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Liver RNA- and protein-degradation rates were measured after the induction of acute inflammation in the rat. A preliminary study determined changes in hepatic RNA and protein content 12, 18 and 24 h after a turpentine oil injection. The RNA content in turpentine-treated rats compared with pair-fed animals increased significantly and sharply from 12 h (+ 11%) to 18 h (+ 32%) and slightly thereafter (+ 37% at 24 h). The liver protein content was significantly enhanced only at 24 h (+ 11%) in response to inflammation. RNA-degradation rates were determined in livers perfused cyclically in situ for 15 min by measuring the accumulation of radioactive cytidine in the medium 60 h after in vivo labelling of RNA by [5-3H]cytidine instead of [6-14C]orotic acid, the most commonly used radioactive marker. Several validation procedures showed that the method employed was a valid alternative to the use of radioactive orotic acid. RNA-degradation rates, which mainly reflect rRNA breakdown, were significantly lower in the turpentine-treated rats than in respective pair-fed animals at 18 and 24 h (57 and 45% decrease respectively). Proteolysis rates measured at 24 h together with RNA breakdown by valine accumulation in the perfusion medium were not modified after turpentine treatment. The main factors known to regulate RNA degradation (amino acids, insulin/glucagon ratio) were measured in the portal blood 24 h after induction of acute inflammation. Of the known regulatory amino acids, only glutamine and to a lesser extent methionine were increased in the turpentine-treated rats as compared with their pair-fed counterparts. The insulin/glucagon molar ratio was similar in both groups. In conclusion, the reduced breakdown of RNA, especially rRNA, is largely responsible for the accumulation of hepatic RNA during acute inflammation. This inhibition of RNA degradation could possibly be related to the increase in glutamine.

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Section: Discussionmentioning

confidence: 99%

Inhibition of liver RNA breakdown during acute inflammation in the rat

Saadane

Neveux

Feldmann

et al. 1996

Biochemical Journal

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“…Measurements of liver protein synthesis and degradation after glucocorticoid administration have yielded conflicting results. Protein synthesis has been reported to be inhibited (Kim & Kim, 1975), unaffected (Hanoune et al, 1972) or stimulated (Feigelson & Feigelson, 1963;Hanoune & Feigelson, 1970;Millward et al, 1976), and protein degradation is increased (Chertow et al, 1973) or unaffected (Kim & Kim, 1975 al., 1974). Dietary differences may also be expected to exert a significant effect on these measurements (Munro, 1964).…”

mentioning

confidence: 99%

Stimulation by glucocorticoids of protein degradation in hepatocyte monolayers

Hopgood¹,

Clark²,

Ballard³

1981

Biochemical Journal

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“…E o êxito de uma StartUp depende também de vários agentes. Por fim, o profissional do Direito desempenha função essencial no cenário em pauta, por justamente traduzir e tornar mais fácil e acessível, ao empreendedor ou empreendedores, a compreensão dos problemas legais (FEIGELSON;NYBO;FONSECA, 2018, p. 15-19).…”

Section: Direito Fundamental Econômico Das Fintechsunclassified

Direito fundamental econômico das fintechs: desenvolvimento brasileiro

Merlone¹

2019

RDJ

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O estudo em comento objetiva refletir e trazer contribuições teóricas e práticas acerca das relações entre fintechs e micro e pequenas empresas. Trata assim do direito fundamental econômico das fintechs e de startups, inovações, empreendedorismo e Direito, além de trazer os desafios e os impactos jurídicos e tecnológicos envolvidos na questão, considerações sobre micro e pequenas empresas, notas sobre a gestão de Pequenas e Médias Empresas de base tecnológica, cobertura de eventos sobre as novas tecnologias no sistema financeiro e, por fim, atividade de inteligência aplicada ao tema com a segurança da informação. Para tanto, foram realizadas revisões bibliográficas por meio de obras físicas consultadas, revistas especializadas e fontes eletrônicas governamentais. Efetuou-se, também, trabalho de campo para cobrir as últimas novidades da pauta. O resultado alcançado se traduz em um cenário onde é possível verificar implicações decorrentes das relações citadas, nas vidas social e econômica do País, com destaque para o desenvolvimento nacional e redução das desigualdades sociais, por intermédio da adequação do Direito aos casos concretos, pelo uso de novas tecnologias e da atividade de inteligência, bem como pela observância da segurança da informação.

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Dr. Feigelson Replies

Cited by 5 publications

References 1 publication

Inhibition of liver RNA breakdown during acute inflammation in the rat

Inhibition of liver RNA breakdown during acute inflammation in the rat

Stimulation by glucocorticoids of protein degradation in hepatocyte monolayers

Direito fundamental econômico das fintechs: desenvolvimento brasileiro

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