DR Detection Using Optical Coherence Tomography Angiography (OCTA): A Transfer Learning Approach with Robustness Analysis

Abstract

OCTA imaging is an emerging modality for the discovery of retinal biomarkers in systemic disease. Several studies have already shown the potential of deep learning algorithms in the medical domain. However, they generally require large amount of manually graded images which may not always be available. In our study, we aim to investigate whether transfer learning can help in identifying patient status from a relatively small dataset. Additionally, we explore if data augmentation may help in improving our classification accuracy. Finally, for the first time, we propose a validation of our model on OCTA images acquired with a different device. OCTA scans from three different groups of participants were analysed: diabetic with and without retinopathy (DR and NoDR, respectively) and healthy subjects. We used the convolutional neural network architecture VGG16 and achieved 83.29% accuracy when classifying DR, NoDR and Controls. Our results demonstrate how transfer learning enables fairly accurate OCTA scan classification and augmentation based on geometric transformations helps in improving the classification accuracy further. Finally, we show how our model maintains consistent performance across OCTA imaging devices, without any re-training.

Euler characteristic surfaces

“…Moreover, we further compare it with the state-of-the-art deep learning approaches to patient classification. A VGG16 architecture with transfer learning was used as described in [5] to classify the same OCTA images.…”

Euler Characteristic Surfaces

“…Moreover, we further compare it with the state-of-the-art deep learning approaches to patient classification. A VGG16 architecture with transfer learning was used as described in [46] to classify the same OCTA images. 2 we can see the classification performance in the 2-class task (Control vs. DR).…”

Topological Detection of Alzheimer’s Disease Using Betti Curves

“…However, the existing methods are known to be incomplete. Though the deep learning approaches from the second group show promising results, there are challenges in terms of generalisation [26,2], bias and data leakage [30]. A recent summary of CNN-based methods and a number of possible issues can be found in [30].…”