DPP-4 Inhibitors

Biftu, Tesfaye; SinhaRoy, Ranabir

doi:10.1016/b978-0-12-409547-2.12443-6

Cited by 3 publications

(1 citation statement)

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“…We speculated that by inducing the up‐regulation of methylthioribulose‐1‐phosphate dehydratase (TRINITY_DN792_c3_g2), trehalose enhanced methionine metabolism in S. pararoseus Y16, and through that, it helped for cell proliferation. Dipeptidyl‐aminopeptidase is an enzyme belonging to the serine protease protein family, which acts as one of yeast's metabolic regulators 48, 49 . In our study, the DEG, Dipeptidyl‐aminopeptidase (TRINITY_DN1305_c0_g3), was up‐regulated in SP‐T1.5% by trehalose.…”

Section: Discussionmentioning

confidence: 55%

Trehalose supplementation enhanced the biocontrol efficiency of Sporidiobolus pararoseusY16 through increased oxidative stress tolerance and altered transcriptome

Dhanasekaran

Yang

Godana

et al. 2021

Pest Management Science

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BACKGROUND In the process of biological control, the antagonistic yeasts contend with various stresses that negatively influence yeasts' biocontrol efficiency. In the current study, we investigated the effect of trehalose supplementation on the biocontrol efficiency and oxidative stress tolerance of Sporidiobolus pararoseus Y16. RESULTS S. pararoseus Y16, an antagonistic yeast cultured in trehalose supplemented medium, exhibited better biocontrol efficiency against Penicillium expansum and Aspergillus tubingensis in table grapes. Trehalose‐treated S. pararoseus Y16 cells showed good proliferation efficiency and oxidative stress tolerance than untreated cells. Increased β‐1,3‐glucanase, catalase, superoxide dismutase activity, and low protein carbonylation were observed in trehalose‐amended S. pararoseus Y16 upon H2O2 exposure. The RNA sequencing results indicated that trehalose significantly altered the transcriptome of S. pararoseus Y16. The GO, KEGG, and COG annotations revealed that the differentially regulated genes corresponded to the various biological process of the yeast. CONCLUSION Our findings suggested that trehalose use could enhance the biocontrol efficiency and oxidative stress tolerance of S. pararoseus Y16. Trehalose supplementation altered the transcriptome of S. pararoseus Y16, particularly the genes that correspond to amino acid metabolism, nucleotide metabolism, and protein modification. Thereby the oxidative stress tolerance and biological control efficiency of S. pararoseus Y16 was enhanced by trehalose. © 2021 Society of Chemical Industry.

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Section: Discussionmentioning

confidence: 55%