DPOAE level shifts and ABR threshold shifts compared to detailed analysis of histopathological damage from noise

Harding, Gary W.; Bohne, Barbara A.; Ahmad, Mueed

doi:10.1016/s0378-5955(02)00653-6

Cited by 73 publications

(74 citation statements)

References 22 publications

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“…Thus, the methodological approach for constructing DP-STCs is crucial to inferring the region where DPOAEs are generated. Importantly, studies free of this limitation such as noise exposure experiments, correlations between DPOAEs, and hearing thresholds, as well as other DPOAE suppression characteristics, support the existence of basal DPOAE sources (e.g., Arnold et al 1999;Harding et al 2002;Dreisbach et al 2008;Martin et al 2009Martin et al , 2010Martin et al , 2011.…”

Section: Broad Region Of Generation Of Oaes Evoked With Complex Stimulimentioning

confidence: 99%

Tuning of SFOAEs Evoked by Low-Frequency Tones Is Not Compatible with Localized Emission Generation

Charaziak

Siegel

2015

JARO

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Stimulus-frequency otoacoustic emissions (SFOAEs) appear to be well suited for assessing frequency selectivity because, at least on theoretical grounds, they originate over a restricted region of the cochlea near the characteristic place of the evoking tone. In support of this view, we previously found good agreement between SFOAE suppression tuning curves (SF-STCs) and a control measure of frequency selectivity (compound action potential suppression tuning curves (CAP-STC)) for frequencies above 3 kHz in chinchillas. For lower frequencies, however, SF-STCs and were over five times broader than the CAP-STCs and demonstrated more high-pass rather than narrow band-pass filter characteristics. Here, we test the hypothesis that the broad tuning of low-frequency SF-STCs is because emissions originate over a broad region of the cochlea extending basal to the characteristic place of the evoking tone. We removed contributions of the hypothesized basally located SFOAE sources by either pre-suppressing them with a high-frequency interference tone (IT; 4.2, 6.2, or 9.2 kHz at 75 dB sound pressure level (SPL)) or by inducing acoustic trauma at high frequencies (exposures to 8, 5, and lastly 3-kHz tones at 110-115 dB SPL). The 1-kHz SF-STCs and CAP-STCs were measured for baseline, IT present and following the acoustic trauma conditions in anesthetized chinchillas. The IT and acoustic trauma affected SF-STCs in an almost indistinguishable way. The SF-STCs changed progressively from a broad high-pass to narrow band-pass shape as the frequency of the IT was lowered and for subsequent exposures to lowerfrequency tones. Both results were in agreement with the Bbasal sources^hypothesis. In contrast, CAP-STCs were not changed by either manipulation, indicating that neither the IT nor acoustic trauma affected the 1-kHz characteristic place. Thus, unlike CAPs, SFOAEs cannot be considered as a place-specific measure of cochlear function at low frequencies, at least in chinchillas.

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Section: Broad Region Of Generation Of Oaes Evoked With Complex Stimulimentioning

confidence: 99%

Tuning of SFOAEs Evoked by Low-Frequency Tones Is Not Compatible with Localized Emission Generation

Charaziak

Siegel

2015

JARO

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“…Suppression patterns, noise-exposure experiments, component decomposition analysis and correlations between OAEs and hearing threshold suggest that SFOAEs, transient-evoked (TE) OAEs, and distortion-product (DP) OAEs in humans and several laboratory species may have an extended generation region (e.g. Sutton 1985;Guinan 1990;Avan et al 1993Avan et al , 1995Avan et al , 1997Withnell et al 2000;Harding et al 2002;Ellison and Keefe 2005;Dreisbach et al 2008;Martin et al 2009Martin et al , 2010Charaziak et al 2013;Sisto et al 2013). …”

Section: Extended Region Of Sfoae Generation At Low Frequenciesmentioning

confidence: 99%

Estimating Cochlear Frequency Selectivity with Stimulus-frequency Otoacoustic Emissions in Chinchillas

Charaziak

Siegel

2014

JARO

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It has been suggested that the tuning of the cochlear filters can be derived from measures of otoacoustic emissions (OAEs). Two approaches have been proposed to estimate cochlear frequency selectivity using OAEs evoked with a single tone (stimulus-frequency (SF)) OAEs: based on SFOAE group delays (SF-GDs) and on SFOAE suppression tuning curves (SF-STCs). The aim of this study was to evaluate whether either SF-GDs or SF-STCs obtained with low probe levels (30 dB SPL) correlate with more direct measures of cochlear tuning (compound action potential suppression tuning curves (CAP-STCs)) in chinchillas. The SFOAE-based estimates of tuning covaried with CAPSTCs tuning for 93 kHz probe frequencies, indicating that these measures are related to cochlear frequency selectivity. However, the relationship may be too weak to predict tuning with either SFOAE method in an individual. The SF-GD prediction of tuning was sharper than CAP-STC tuning. On the other hand, SF-STCs were consistently broader than CAP-STCs implying that SFOAEs may have less restricted region of generation in the cochlea than CAPs. Inclusion of G3 kHz data in a statistical model resulted in no significant or borderline significant covariation among the three methods: neither SFOAE test appears to reliably estimate an individual's CAP-STC tuning at low-frequencies. At the group level, SF-GDs and CAP-STCs showed similar tuning at low frequencies, while SF-STCs were over five times broader than the CAP-STCs indicating that low-frequency SFOAE may originate over a very broad region of the cochlea extending ≥5 mm basal to the tonotopic place of the probe.

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“…After excessive exposure to noise, both HCs and SGNs can be damaged (Liberman and Kiang 1978;Harding et al 2002;Kujawa and Liberman 2009). Despite the capacity of peripheral neurons to regenerate, SGNs in mammals do not spontaneously recover from injury (Starr et al 1996;White et al 2000;McFadden et al 2004;Kujawa and Liberman 2009).…”

Section: Introductionmentioning

confidence: 99%

Regenerated Synapses Between Postnatal Hair Cells and Auditory Neurons

Tong

Brugeaud

Edge

2013

JARO

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Regeneration of synaptic connections between hair cells and spiral ganglion neurons would be required to restore hearing after neural loss. Here we demonstrate by immunohistochemistry the appearance of afferent-like cochlear synapses in vitro after co-culture of de-afferented organ of Corti with spiral ganglion neurons from newborn mice. The glutamatergic synaptic complexes at the ribbon synapse of the inner hair cell contain markers for presynaptic ribbons and postsynaptic densities. We found postsynaptic density protein PSD-95 at the contacts between hair cells and spiral ganglion neurons in newly formed synapses in vitro. The postsynaptic proteins were directly facing the CtBP2-positive presynaptic ribbons of the hair cells. BDNF and NT-3 promoted afferent synaptogenesis in vitro. Direct juxtaposition of the postsynaptic densities with the components of the preexisting ribbon synapse indicated that growing fibers recognized components of the presynaptic sites. Initiation of cochlear synaptogenesis appeared to be influenced by glutamate release from the hair cell ribbons at the presynaptic site since the synaptic regeneration was impaired in glutamate vesicular transporter 3 mutant mice. These insights into cochlear synaptogenesis could be relevant to regenerative approaches for neural loss in the cochlea.

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DPOAE level shifts and ABR threshold shifts compared to detailed analysis of histopathological damage from noise

Cited by 73 publications

References 22 publications

Tuning of SFOAEs Evoked by Low-Frequency Tones Is Not Compatible with Localized Emission Generation

Tuning of SFOAEs Evoked by Low-Frequency Tones Is Not Compatible with Localized Emission Generation

Estimating Cochlear Frequency Selectivity with Stimulus-frequency Otoacoustic Emissions in Chinchillas

Regenerated Synapses Between Postnatal Hair Cells and Auditory Neurons

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