DPD studies on mixed micelles self-assembled from MPEG-PDEAEMA and MPEG-PCL for controlled doxorubicin release

Yang, Chufen; Yuan, Cong; Liu, Wenyao; Guo, Juan; Feng, Dachun; Yin, Xijie; Lin, Wenjing; Shuttleworth, Peter S.; Yue, Hangbo

doi:10.1016/j.colsurfb.2019.02.043

Cited by 34 publications

(25 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The stability is one of the key parameters of drug delivery system, and it is dependent on the Gibbs free energy of system that is approximately proportional to the CMC values. Typically, the lower CMC value means a more negative Gibbs free energy, reflecting the higher stability of drug delivery system [ 37 ]. In our work, the CMC values of polymers L-PLGA-D-P and S-PLGA-D-P were measured in aqueous solutions by fluorescence spectroscopy using pyrene as a fluorescence probe.…”

Section: Resultsmentioning

confidence: 99%

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Wen

Guo

2021

Nanomaterials

Self Cite

View full text Add to dashboard Cite

Four-arm star-shaped (denoted as ‘S’) polymer adamantane-[poly(lactic-co-glycolic acid)-b-poly(N,N’-diethylaminoethyl methacrylate) poly(ethylene glycol) monomethyl ether]4 (S-PLGA-D-P) and its linear (denoted as ‘L’) counterpart (L-PLGA-D-P) were synthesized, then their self-assembled micelles were further developed to be platforms for anticancer drug delivery. Two types of polymeric micelles exhibited strong pH-responsiveness and good drug loading capacity (21.6% for S-PLGA-D-P and 22.9% for L-PLGA-D-P). Using doxorubicin (DOX) as the model drug, their DOX-loaded micelles displayed well controlled drug release behavior (18.5–19.0% of DOX release at pH 7.4 and 77.6–78.8% of DOX release at pH 5.0 within 80 h), good cytocompatibility against NIH-3T3 cells and effective anticancer efficacy against MCF-7 cells. However, the star-shaped polymeric micelles exhibited preferable stability, which was confirmed by the lower critical micelle concentration (CMC 0.0034 mg/mL) and decrease rate of particle sizes after 7 days incubation (3.5%), compared with the linear polymeric micelle L-PLGA-D-P (CMC 0.0070 mg/mL, decrease rate of particle sizes was 9.6%). Overall, these developed polymeric micelles have promising application as drug delivery system in cancer therapy.

show abstract

Section: Resultsmentioning

confidence: 99%

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Wen

Guo

2021

Nanomaterials

Self Cite

View full text Add to dashboard Cite

show abstract

“…In this work, ρ is set to 3. Among them, the Flory-Huggins parameter χ can be obtained from the solubility parameter δ obtained by calculating the intermolecular interaction strength and cohesive energy of liquid objects [28,29]:…”

Section: Modeling and Simulation Methodsmentioning

confidence: 99%

Application of Mesoscale Simulation to Explore the pH Response of Eudragit S100 Used as the Novel Colon-Targeted Powder of Pulsatilla Saponin D

Gong¹,

Chen²,

Zhou³

et al. 2021

Journal of Nanomaterials

View full text Add to dashboard Cite

As a pH-sensitive nanomaterial, Eudragit S100 has good colon targeting. However, little research has been carried out on its mesoscopic scale. In this paper, the self-assembly behavior of Pulsatilla saponins D (PSD) and Eudragit S100, as well as the loading and release mechanism of PSD, was investigated via computer simulations. The effects of the self-assembly characteristics of PSD and Eudragit S100 in the dry powder state on the drug-carrier ratio were explored by the coarse-grained molecular dynamics (CGMD) method. According to the pH-responsive feature of Eudragit S100, the drug protection under gastric pH conditions and release in colonic pH conditions were simulated through the dissipative particle dynamics (DPD) method, which has provided insights into the microscopic morphological changes in the pH-sensitive drug delivery systems.

show abstract

“…Besides the above systems, the multicore assemblies forming in mixtures of linear copolymers [212], the self-assembling amphiphilic homopolymers [213], side-chain discotic liquid crystalline polymers [214], polymers tethered to nanoparticles and mixtures of copolymers with nanoparticles [215,216] and the 'shape amphiphiles' [217][218][219][220][221] have been successfully studied by DPD. Because the most promising and very intensively studied application of polymeric nanoparticles is the targeted transport of drugs in living organisms and their controlled release [17,21,23,25], several DPD and combined experimental-DPD studies have also been published recently [176,177,183,[222][223][224][225]. Concerning biomedical applications, the relatively recent reviews by Biswas [225] and Chen [226], and particularly the references therein, are of interest.…”

Section: Experiment-inspired and Application-orientated Papersmentioning

confidence: 99%

DPD Modelling of the Self- and Co-Assembly of Polymers and Polyelectrolytes in Aqueous Media: Impact on Polymer Science

et al. 2022

View full text Add to dashboard Cite

This review article is addressed to a broad community of polymer scientists. We outline and analyse the fundamentals of the dissipative particle dynamics (DPD) simulation method from the point of view of polymer physics and review the articles on polymer systems published in approximately the last two decades, focusing on their impact on macromolecular science. Special attention is devoted to polymer and polyelectrolyte self- and co-assembly and self-organisation and to the problems connected with the implementation of explicit electrostatics in DPD numerical machinery. Critical analysis of the results of a number of successful DPD studies of complex polymer systems published recently documents the importance and suitability of this coarse-grained method for studying polymer systems.

show abstract

DPD studies on mixed micelles self-assembled from MPEG-PDEAEMA and MPEG-PCL for controlled doxorubicin release

Cited by 34 publications

References 36 publications

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Acid-Responsive Adamantane-Cored Amphiphilic Block Polymers as Platforms for Drug Delivery

Application of Mesoscale Simulation to Explore the pH Response of Eudragit S100 Used as the Novel Colon-Targeted Powder of Pulsatilla Saponin D

DPD Modelling of the Self- and Co-Assembly of Polymers and Polyelectrolytes in Aqueous Media: Impact on Polymer Science

Contact Info

Product

Resources

About