Doxycycline sclerotherapy as primary treatment of head and neck lymphatic malformations in children

Nehra, Deepika; Jacobson, Lara M.; Barnes, Pat; Mallory, Baird; Albanese, Craig T.; Sylvester, Karl G.

doi:10.1016/j.jpedsurg.2007.10.009

Cited by 115 publications

(68 citation statements)

References 19 publications

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“…Several drugs or chemicals have been used as agents for sclerotherapy of LM, including bleomycin, doxycycline, ethanol, and OK-432 (3,(19)(20)(21). Despite the complications by penetration into adjacent tissue, ethanol has been used as the strongest sclerosant for more definite results (10,22,23).…”

Section: Discussionmentioning

confidence: 99%

Infusion Sclerotherapy of Microcystic Lymphatic Malformation: Clinico-Radiological Mid-Term Results

Lee

Chung

et al. 2016

J Korean Soc Radiol

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Purpose:A new sclerotherapy technique by slow mechanical infusion of sclerosant was validated for treatment of microcystic lymphatic malformation (mLM). Materials and Methods: Seventeen consecutive patients with mLM in extremities, cervicofacial area, and trunk were included (21.8 ± 21.5 years old, male:female = 5:12). All patients diagnosed as mLM were included. A total 4-32 mL 20-38% OK-432 solution was mechanically infused at the rate of 10 mL/hour into the mLM lesions. The treatment effect was estimated clinic-radiologically at the 4-month follow-up. Repeated sclerotherapy followed in the 6th month, if required. The therapeutic effect was evaluated using quantitative ultrasonographic examination including soft tissue thickness, cyst size and number. Results: In 17 patients, total 31 infusion sclerotherapy sessions were performed and monitored for 425 ± 266 days. Fifteen patients (88%) showed improvement in all symptoms, signs, and ultrasonographic findings. In all cases, at least one finding presented improvement. The maximal number of cysts per ultrasonographic window and maximal diameter of the largest cyst decreased by 57 ± 57% and 51 ± 67%, respectively (p = 0.102, 0.004). The soft tissue thickness decreased by 18 ± 15% (p < 0.01). No significant complications such as distal lymphedema or skin necrosis occurred. Conclusion: Infusion sclerotherapy is a safe and effective treatment technique for microcystic LM, with improved outcome.

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Section: Discussionmentioning

confidence: 99%

Infusion Sclerotherapy of Microcystic Lymphatic Malformation: Clinico-Radiological Mid-Term Results

Lee

Chung

et al. 2016

J Korean Soc Radiol

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“…The authors of this report therefore feel that it might be prudent to secure the airway, by means of a tracheostomy, prior to OK-432 injection where there is the potential for airway compromise. The use of doxycycline as a sclerosant in LMs has previously been reported [25,26]. These reports were however limited to use in macrocystic and combined cases.…”

Section: Discussionmentioning

confidence: 99%

Lymphatic malformations: A proposed management algorithm

Oosthuizen¹,

Burns²,

Russell³

2010

International Journal of Pediatric Otorhinolaryngology

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“…Intralesional Bleomycin has a reported rate of complete resolution in only 50% of cases, and has a variety of complications including infection, gastrointestinal disturbances and pulmonary fibrosis 11 . Sclerotherapy with doxycycline needs close monitoring as patient may develop hypoglycemia with elevated systemic level of doxycycline and patient should be monitored for metabolic acidosis 12,13 .…”

Section: Discussionmentioning

confidence: 99%

Complete Surgical Excision with Keeping Drain Tube in Situ for 2 to 3 Weeks in the Treatment of Cystic Hygroma: A study of 5 years

Paul

Howlader

Saha

et al. 2016

Faridpur Med Coll J

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Abstract:Lymphangiomas are benign hamartomatous lymphatic tumours characterized by multiple communicating lymphatic channels and cystic spaces. Cystic lyphangiomas may be seen anywhere in the body but are common in neck, axilla, mediastinum and groin. Treatment options are surgical resection, radiation, sclerotherapy etc but have got high recurrence rate and complications. In the present study we hypothesized that complete surgical resection along with keeping a drain for 2-3 wks, may reduce recurrence rate. This prospective study was performed from July 2008 to June 2013. Total 21 children treated during this period by the technique of complete surgical excision with keeping drain tube in situ for 2 to 3 weeks. Ultrasound performed in all patients, CT scan and Duplex study performed in some patients, histopathology done in all patients. Patients with intra-abdominal lymphangioma not included in this study. Twenty one patients were operated during the study period and average duration of keeping drain tube was 18.57 days. Among the 21 cases 2 (9.52%) patients developed mild infection, 1 (4.76%) patient developed infection with pus formation and 1 (4.76%) patient developed recurrence. Our success in the treatment warrants further verification of potential benefits of keeping drain tube in situ for 2-3 weeks after surgical excision of lymphangiomas.

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Doxycycline sclerotherapy as primary treatment of head and neck lymphatic malformations in children

Cited by 115 publications

References 19 publications

Infusion Sclerotherapy of Microcystic Lymphatic Malformation: Clinico-Radiological Mid-Term Results

Infusion Sclerotherapy of Microcystic Lymphatic Malformation: Clinico-Radiological Mid-Term Results

Lymphatic malformations: A proposed management algorithm

Complete Surgical Excision with Keeping Drain Tube in Situ for 2 to 3 Weeks in the Treatment of Cystic Hygroma: A study of 5 years

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