Doxycycline-coated sutures improve mechanical strength of intestinal anastomoses

Pasternak, Björn; Rehn, Matilda; Andersen, Lars Willy; Ågren, Magnus S.; Heegaard, Anne‐Marie; Tengvall, Pentti; Aspenberg, Per

doi:10.1007/s00384-007-0401-0

Cited by 47 publications

(36 citation statements)

References 22 publications

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“…21,22 Two included randomized controlled trials (RCTs) 23,24 on suture material failed to achieve a unanimous conclusion because of the small number of patients included and the different suture materials tested that are rarely used today.…”

Section: Suture Materialsmentioning

confidence: 99%

“…Today most gastrointestinal anastomoses, including colorectal anastomosis, are constructed with polydioxanone sutures. Ten experimental studies [13][14][15][16][17][18][19][20][21][22] were included. Results show that absorbable sutures compared with nonabsorbable or slowly absorbable sutures cause more tissue reaction [13][14][15] ; one of these studies 13 showed that absorbable sutures dissolve too rapidly, influencing anastomotic strength.Multifilamentcomparedwithmonofilamentsutures cause more tissue damage and easier adherence of material within the interstices of multifilament sutures, [16][17][18][19] providing a basis for infection.…”

Section: Suture Materialsmentioning

confidence: 99%

See 1 more Smart Citation

Systematic Review of the Technique of Colorectal Anastomosis

Slieker

Daams²,

Mulder³

et al. 2013

JAMA Surg

166

102

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Section: Suture Materialsmentioning

confidence: 99%

Section: Suture Materialsmentioning

confidence: 99%

Systematic Review of the Technique of Colorectal Anastomosis

Slieker

Daams²,

Mulder³

et al. 2013

JAMA Surg

166

102

View full text Add to dashboard Cite

“…[20,21] MMP-1, -2, and -9 levels in peroperative intestinal biopsies were elevated in patients who developed anastomotic wound failure after colorectal resection. [22] While, MMP inhibitors have been shown to improve healing of intestinal and cutaneous wounds [23,24,25] MMP-3 levels appear to be related to the prognosis of osteoarthritis as well. MMP inhibitor therapy has already been tried.…”

Section: Mmps and Adamtsmentioning

confidence: 99%

Analysis of ADAMTS, MMPs, Versican and Related Proteoglycans in Origin and Progression of BRONJ

Sidhu¹

2015

J Cont Med A Dent

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“…Breaking strength is typically measured using a tensiometer [23,24] by applying increasing force in a longitudinal direction to anastomotic segments until disruption takes place [16]. In this study, the resected intestinal segments, with the sutures in place, were placed in a dynamometer (Haas-Automatyka, Bielsko-Biała, Poland) at a force of 200 newtons (N); the force was then increased at a rate of 10 mm/min.…”

Section: Breaking Strengthmentioning

confidence: 99%

Compression Anastomosis Clips Versus a Hand-Sewn Technique for Intestinal Anastomosis in Pigs

Kuśnierz¹,

Kajor²,

Żaworonkow³

et al. 2016

Adv Clin Exp Med

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Different types of sutures, staples and sutureless anastomoses have been used to create anastomoses. The ideal device should ensure good serosal apposition without requiring either transgression of the bowel wall or the presence of foreign material for an extended period of time [2]. Healing occurs when the surgical wound is clean and sharp, Anastomotic dehiscence and leaks are major problems in gastrointestinal surgery and result in increased morbidity and mortality, thus decreasing overall survival. Intestinal anastomosis healing depends on the operative technique, the underlying medical condition, medical treatment and other individual, often unknown, factors AbstractBackground. Anastomotic dehiscence and leaks are major problems in gastrointestinal surgery and result in increased morbidity and mortality. The ideal device to create anastomoses should ensure good serosal apposition without requiring either transgression of the bowel wall or the presence of foreign material for an extended period of time. Objectives. The aim of this experimental study was to evaluate the safety and efficacy of a new compression anastomosis clip (CAC) for jejunojejunostomies and ileocolostomies by comparing CAC anastomoses with hand-sewn (HS) anastomoses in pigs in terms of healing, breaking strength and the time to create anastomoses. Material and Methods. The 11 pigs in the study underwent side-to-side CAC and HS jejunojejunostomies and ileocolostomies, for a total of 88 anastomoses. The pigs were sacrificed on postoperative day 5 (5 pigs) or 7 (6 pigs). Macroscopic, histopathological and breaking-strength examinations were performed. The time to create the anastomoses was recorded. Results. Neither group had anastomotic complications such as leakage or obstruction. Macroscopic examination showed no statistically significant differences between the groups. In the CAC group, the healing process was characterized by a lesser inflammatory reaction (p < 0.05) and very thin scar tissue at the anastomotic line (less collagen deposition and better epithelial regeneration), while the HS group had a much thicker anastomotic line. The breaking strength was significantly greater in the CAC group compared with the HS group (p < 0.05). The anastomosis time was shorter in the CAC group than in the HS group (p < 0.01). Conclusions. Anastomosis using a CAC appears to be safe and less time-consuming than HS; it was also characterized by a good healing process with little inflammatory reaction and a high breaking strength compared with HS anastomosis (Adv Clin Exp Med 2015, 24, 6, 000-000).

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Doxycycline-coated sutures improve mechanical strength of intestinal anastomoses

Abstract: Background and aims: After resection and repair of the intestines, tissue degradation

Cited by 47 publications

References 22 publications

Systematic Review of the Technique of Colorectal Anastomosis

Systematic Review of the Technique of Colorectal Anastomosis

Analysis of ADAMTS, MMPs, Versican and Related Proteoglycans in Origin and Progression of BRONJ

Compression Anastomosis Clips Versus a Hand-Sewn Technique for Intestinal Anastomosis in Pigs

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