Doxycycline and Coenzyme Q10 Treatment Modalities for Chronic Periodontitis: A Preliminary Study

Darweesh, Mahmoud; El-Sharkawy, Hesham; Fadhil, Omar N; Maria, Ola M.

doi:10.23937/2469-5734/1510014

Cited by 8 publications

(20 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The total observation period ranged from one to six months. Eight studies tested CoQ10 in an FM [ 35 , 36 , 37 , 39 , 42 , 44 , 45 , 46 ], eight in an SM study design [ 38 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ], and one did not clearly report the design [ 43 ]. Only three studies applied a placebo [ 45 , 48 , 49 ], and all other studies were controlled against SRP alone.…”

Section: Resultsmentioning

confidence: 99%

“…In case of missing or unclear information, attempts were made to contact the authors. For this purpose, the corresponding authors of five studies [ 35 , 36 , 37 , 38 , 39 ] were contacted twice (November 2021 and January 2022) via the provided email addresses. All answers until November 2022 were considered.…”

Section: Methodsmentioning

confidence: 99%

“…All answers until November 2022 were considered. Two authors provided further information [ 35 , 36 ].…”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Systematic Review on Protocols of Coenzyme Q10 Supplementation in Non-Surgical Periodontitis Therapy

et al. 2023

View full text Add to dashboard Cite

This systematic review focuses on the different study protocols on CoQ10 as an adjunct in non-surgical periodontitis therapy. The study protocol was developed following PRISMA guidelines and was registered in PROSPERO (CRD42021156887). A sensitive search up to January 2022 considered MEDLINE via PubMed and Web of Science, Embase, Web of Science Core Collection via Web of Science, Google Scholar, Cochrane CENTRAL, WHO (ICTRP), ClinicalTrials.gov, and grey literature. Randomized controlled (SRP with/without placebo) clinical trials (RCTs) on all types of CoQ10 administration were included. The primary outcome was probing pocket depth (PPD). Secondary outcomes were bleeding on probing, clinical attachment loss, and gingival and plaque indices. Twelve RCTs with local and five with systemic CoQ10 administration were included. The study protocols were heterogeneous. Local CoQ10 administration was performed once or several times in a period up to 15 days. Systemic CoQ10 was applied twice or three times daily for six weeks up to four months. The reporting quality was low, including missing information about CoQ10 doses. Risk of bias was high or unclear. About half of the studies reported significant group differences for PPD. Until now, no statement on the effectiveness of CoQ10 in non-surgical periodontitis therapy is possible. Further high-quality RCTs are necessary and should consider the protocol recommendations of this review.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Systematic Review on Protocols of Coenzyme Q10 Supplementation in Non-Surgical Periodontitis Therapy

et al. 2023

View full text Add to dashboard Cite

show abstract

“…COL1A1 is the main component of extracellular matrix and is also one of the marker genes expressed in early stage of osteogenic differentiation [ 71 ]. No significant differences were detected among the three groups for the OCN values at 3 months after healing of the extraction sockets that might be due to the short-term study period (3 months) that did not allow sufficient bone formation to occur, which, in term, affects the osteocalcin levels [ 72 ]. OPN expression showed higher values in the CoQ10 group than in the other groups at three months of healing of the extraction sockets that was in an agreement to a study showing that CoQ10 protects against osteoporosis and may regulate bone metabolism indicating CoQ10 as a potential safe therapeutic used to treat human diseases [ 73 ].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Coenzyme Q10/Collagen Hydrogel on Bone Regeneration in Extraction Socket Prior to Implant Placement in Type II Diabetic Patients: A Randomized Controlled Clinical Trial

Ghanem

Heikal

Fattah

et al. 2022

JCM

View full text Add to dashboard Cite

Background: The healing of an extraction socket leads to alveolar ridge resorption that can hinder future implant placement and further rehabilitation with special concerns in diabetes mellitus. Coenzyme Q10 (CoQ10) has been developed as a new material for alveolar socket augmentation. The aim of this study was to investigate the effect of CoQ10 hydrogel on bone regeneration after extraction of mandibular teeth in Type II diabetic patients. Methods: This trial was registered under the number NCT05122299 and included eighteen patients. The hydrogel was first prepared and characterized. After tooth extraction, the hydrogel was placed in the extraction sockets. Bone formation was evaluated three months after tooth extraction. Results: The bone density was significantly higher in the CoQ10 group than the other two groups measured on cone beam computed tomography (CBCT). The relative gene expression of Runt-related transcription factor 2 (RUNX2) and Osteopontin (OPN) showed significant increase in the presence of CoQ10. Histomorphometry revealed significantly less fibrous tissue in the CoQ10 group in comparison to the control or collagen group. Conclusion: The local application of CoQ10 after tooth extraction provided a simple, inexpensive, yet effective treatment facilitating bone formation and healing in the extraction sockets of diabetic patients.

show abstract

“…This double action of CoQ10 could be the reason for its effect being equivalent to that of triamcinolone. Topical CoQ10 has been previously investigated in other oral conditions, such as periodontal and gingival conditions and showed a great clinical reduction in the in ammatory condition after a few weeks (Prakash et 2010, Darweesh et al, 2015, Raut et al, 2019, Pranam et al 2020.…”

Section: Discussionmentioning

confidence: 99%

Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial

2019

CMR

View full text Add to dashboard Cite

Background: Oral lichen planus (OLP) is a chronic mucocutaneous immunologically mediated condition that has a great adverse effect on oral functions.Corticosteroids are still the rst drugs of choice used in the treatment of OLP, however, they have extensive medical side effects. The present study was carried out to assess the clinical therapeutic effect of topical use of coenzyme Q10 (coQ10 or ubiquinol) versus topical corticosteroids in the management of symptomatic OLP and to determine whether the effect, if any, was due to the powerful antioxidant activity of coQ10.Subjects and Methods: We performed a randomized, double blinded controlled trial at the Faculty of Dentistry, Cairo University, Egypt. The study was conducted on 34 patients suffering from symptomatic OLP. Patients were randomly divided into two groups, intervention group (I), who received topical CoQ10 in the form of mucoadhesive tablets (40% CoQ10) 3 times daily for one month and control group (II), who received topical corticosteroid (kenacort in Orabase: triamcinolone acetonide 0.1% 5 gram adhesive paste -dermapharm), 4 times daily for one month. Patients were evaluated at one-week intervals using the clinical parameters (score) of pain (VAS) and lesion size. Additionally, salivary levels of malondialdehyde (MDA) were assessed in both groups before and after treatment using ELISA. All recorded data wereanalysed using independent t test, ANOVA followed by Bonferroni post hoc test for lesion size and salivary level of MDA data and Mann-Whitney U test and Friedman test for VAS data.Results: Both groups showed a signi cant reduction in pain and size of the lesions (p ≤ 0.05) with no statistically signi cant difference between them (p>0.05) and this clinical improvement was associated with a reduction in the salivary levels of MDA in both groups.Conclusions: The topical use of CoQ10 mucoadhesive tablets was as effective as the topical use of triamcinolone acetonide, and its clinical effect was associated with reduction in the salivary level of MDA.Trial registration: The study protocol was registered at www.clinicaltrial.gov (NCT04091698) and registration date: 17/9/2019.

show abstract

Doxycycline and Coenzyme Q10 Treatment Modalities for Chronic Periodontitis: A Preliminary Study

Cited by 8 publications

References 32 publications

Systematic Review on Protocols of Coenzyme Q10 Supplementation in Non-Surgical Periodontitis Therapy

Systematic Review on Protocols of Coenzyme Q10 Supplementation in Non-Surgical Periodontitis Therapy

The Effect of Coenzyme Q10/Collagen Hydrogel on Bone Regeneration in Extraction Socket Prior to Implant Placement in Type II Diabetic Patients: A Randomized Controlled Clinical Trial

Clinical and Biochemical Assessment of the Effect of Topical Use of Coenzyme Q10 Versus Topical Corticosteroid in Management of Symptomatic Oral Lichen Planus: Randomized Controlled Clinical Trial

Contact Info

Product

Resources

About