Doxorubicin Nanocarriers Based on Magnetic Colloids with a Bio‐polyelectrolyte Corona and High Non‐linear Optical Response: Synthesis, Characterization, and Properties

Abstract

Magnetic drug nanocarriers are synthesized following an arrested mineralization of magnetic spinel iron oxides in the presence of the biopolymer of sodium carboxymethylcellulose. Based on the experimental results, the polyelectrolyte corona probably attains a brushlike configuration around the magnetic particles. The inner core of these colloids may be constituted of polymer‐associated nanocrystallites, forming nanogel colloids. The hybrid colloids are endowed with a high loading capacity for the anticancer agent doxorubicin and pronounced pH responsiveness. They also display a dramatic increase in non‐linear optical response as compared to previous studies of similar materials. Furthermore, as cell studies indicate, the blank nanocarriers are cytocompatible and the drug retains its activity after loading in the nanocarriers.

Enhancing Tumor Cell Response to Chemotherapy through the Targeted Delivery of Platinum Drugs Mediated by Highly Stable, Multifunctional Carboxymethylcellulose‐Coated Magnetic Nanoparticles

“…The stability with respect to ionic strength was tested by means of the variation of hydrodynamic diameter with different ionic strengths over a broad range of solution salinity (Figure A). The magnetic nanocluster cMNPs prepared in this work exhibit improved stability when compared with the nanoparticles prepared previously by Bakandritsos et al . The d H of the cMNPs exceeded 200 nm at 0.5 m concentration of NaCl whereas the MNPs prepared according to the original protocol exceeded the 200 nm limit of d H at 0.03 m NaCl.…”

“…The transmission electron microscopy (TEM) images (Figure A) of the colloidal MNPs show their structural organization, demonstrating that the densely packed cMNPs are arranged into superclusters whereas the cMNPs prepared as described in the previous study by Bakandritsos et al . self‐assemble into chain‐like morphologies.…”

“…A similar supercluster morphology has been described previously, when polysaccharide alginate appeared to dictate the growing nanocrystallites specific cluster type of aggregation. Some of the carboxy groups of CMC interact with iron ions on the surfaces of the NPs, which results in polysaccharide adsorption, as described earlier …”

“…The absorbance was measured at 450 nm. The results are presented based on the normalized absorbance (ABS norm ): ABS norm =[(ABS t −ABS f )/ABS i ], in which ABS t is the actual absorbance recorded as a function of time, ABS f is the absorbance at 6000 s, and ABS i is the absorbance at 2000 s. The decay of the magnetic field of a particular magnet with distance (the magnetic field gradient) has been previously measured . The present magnetic colloids were compared with previously studied and published magnetic nanocarriers (MagP), which were synthesized in this work and their magnetophoretic response recorded again.…”

Advanced Sensing of Antibiotics with Magnetic Gold Nanocomposite: Electrochemical Detection of Chloramphenicol

“…Recently, it has been shown that Au NPs can be produced using cellulose derivatives including cellulose ethers, methylhydroxyethyl cellulose, and carboxymethyl cellulose as reducing agents . In this work, CMC was used as a stabilizing agent for magnetite NPs according to the previously described protocol …”