Doxorubicin Loading, Release, and Stability of Polyamidoamine Dendrimer-Coated Magnetic Nanoparticles

Khodadust, Rouhollah; Mutlu, Pelin; Yalçın, Serap; Ünsoy, Gözde; Gündüz, Ufuk

doi:10.1002/jps.23524

Cited by 40 publications

(26 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The surface functional groups at the surface of G4DcMNPs were flexible and the distance between these groups was adequate for doxorubicin to enter into the cavities inside the derdrimer [18]. In order to obtain the most effective delivery systems, here poly (I:C) modified, doxorubicin loaded G4DcMNPs (PIC-G4DcMNPs-Dox) were prepared for targeted cancer therapy.…”

Section: Poly (I:c) Binding On G4dcmnps-dox and Binding Optimizationmentioning

confidence: 99%

“…The second important problem is the gain of resistance to doxorubicin, which limits its application [16]. In order to overcome the resistance mechanism, doxorubicin was loaded into the cavities of synthesized DcMNPs [17][18][19]. Loading of drug into the cavities of PAMAM dendrimers enhances its aqueous solubility, bioavailability, and controls its release profile [18,20].…”

mentioning

confidence: 99%

“…In order to overcome the resistance mechanism, doxorubicin was loaded into the cavities of synthesized DcMNPs [17][18][19]. Loading of drug into the cavities of PAMAM dendrimers enhances its aqueous solubility, bioavailability, and controls its release profile [18,20]. At the same time, loading of drug into nanoparticles will help the doxorubicin to bypass Pgp-mediated efflux proteins [19,21,22].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy

Khodadust¹,

Ünsoy²,

Gündüz³

2014

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

Section: Poly (I:c) Binding On G4dcmnps-dox and Binding Optimizationmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy

Khodadust¹,

Ünsoy²,

Gündüz³

2014

Biomedicine & Pharmacotherapy

View full text Add to dashboard Cite

“…At each time interval, 2 mL of the buffer was collected, and the absorbance was measured at 500 nm. Furthermore, the volume of the outer phase buffer was kept constant by replenishing with the corresponding fresh buffer solution used in the system, according to previous protocols 65, 71

Cumulative release (%) = \frac{Concentration of drug release}{Concentration of drug load} \times 100 %

…”

Section: Methodsmentioning

confidence: 99%

Radiation‐Sensitive Dendrimer‐Based Drug Delivery System

Chou

Yuh

et al. 2017

Advanced Science

View full text Add to dashboard Cite

Combination of chemotherapy and radiotherapy is used to enhance local drug delivery while reducing off‐target tissue effects. Anticancer drug doxorubicin (DOX) is loaded into l‐cysteine modified G4.5 dendrimer (GC/DOX) and released at different pH values in the presence and absence of γ‐radiation. Presence of γ‐radiation significantly improves DOX release from the GC/DOX under acidic pH conditions, suggesting that GC dendrimer is a radiation‐sensitive drug delivery system. GC/DOX is further evaluated by determining cytotoxicity in uterine cervical carcinoma HeLa cells. GC/DOX shows high affinity for cancer cells and effective drug release following an external stimulus (radiation exposure), whereas an in vivo zebrafish study confirms that l‐cysteine acts as a radiosensitizer. GC/DOX treatment combined with radiotherapy synergistically and successfully inhibits cancer cell growth.

show abstract

“…Their synthesis results in high level of control over size, branching points and surface functionality. Several kinds of inorganic nanoparticles, coated with dendrimers are reported in literature for drug and gene delivery [36][37][38] or imaging [39].…”

Section: Dendrimersmentioning

confidence: 99%

Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility

et al. 2014

View full text Add to dashboard Cite

Diagnostic-and therapeutic release-aimed nanoparticles require the highest degree of biocompatibility. Some physical and chemical characteristics of such nanomaterials are often at odds with this requirement. For instance, metals with specific features used as contrast agents in magnetic resonance imaging need particular coatings to improve their blood solubility and increase their biocompatibility. Other examples come from the development of nanocarriers exploiting the different characteristics of two or more materials, i.e., the ability to encapsulate a certain drug by one core-material and the targeting capability of a different coating surface. Furthermore, all these "human-non-self" modifications necessitate proofs of compatibility with the immune system to avoid inflammatory reactions and resultant adverse effects for the patient. In the present review we discuss the molecular interactions and responses of the immune system to the principal nanoparticle surface modifications used in nanomedicine.

show abstract

Doxorubicin Loading, Release, and Stability of Polyamidoamine Dendrimer-Coated Magnetic Nanoparticles

Cited by 40 publications

References 50 publications

Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy

Development of poly (I:C) modified doxorubicin loaded magnetic dendrimer nanoparticles for targeted combination therapy

Radiation‐Sensitive Dendrimer‐Based Drug Delivery System

Biomedical Nanoparticles: Overview of Their Surface Immune-Compatibility

Contact Info

Product

Resources

About