Doxorubicin-loaded oligonucleotide conjugated gold nanoparticles: A promising in vivo drug delivery system for colorectal cancer therapy

Lee, Chang‐Seuk; Kim, Hyungjoo; Yu, Joonhee; Yu, Su; Ban, Seona; Oh, Seung-Hyun; Jeong, Dongjun; Im, Jungkyun; Baek, Moo Jun; Kim, Tae Hyun

doi:10.1016/j.ejmech.2017.08.063

Cited by 84 publications

(45 citation statements)

References 45 publications

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“…Drug delivery systems (DDSs) comprising of nanomedicine with nanocarriers permit drugs and medical therapies to play role in more convenient, safe and efficient way [11]. Noble metal (Ag and Au) and metal oxide nanoparticles (Fe 3 O 4 , NiO, CoO, ZnO and SnO 2 ) are promising materials for drug delivery [16][17][18]. Among these, zinc oxide (ZnO) nanoparticles involvement in cancer therapy has received much attention.…”

Section: Introductionmentioning

confidence: 99%

Enhanced drug efficiency of doped ZnO–GO (graphene oxide) nanocomposites, a new gateway in drug delivery systems (DDSs)

Afzal

Ikram

Ali

et al. 2020

Mater. Res. Express

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Graphene oxide (GO) nanosheets were doped to zinc oxide (ZnO) nanoparticles using a facile chemical deposition method. X-ray diffraction (XRD) confirmed the presence of hexagonal structure and increased peaks broadening upon doping. Undoped and ZnO doped GO sheets showed morphology like nanoparticles, nanorods and flakes were observed under transmission and field emission electron microscopies respectively. An increase in absorption was observed in absorption spectra upon doping recorded via UV-visible spectroscopy. The hydrogen bonding between functional groups of GO and ZnO is responsible for limiting maximum drug loading efficiency. GO doped ZnO has higher drug loading efficiency of about 89% compared to ZnO (82%) and this trend reverse in drug releasing process. This study will provide an efficient design of the drug delivery system for dissolution enhancement according to the required drug release.

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Section: Introductionmentioning

confidence: 99%

Enhanced drug efficiency of doped ZnO–GO (graphene oxide) nanocomposites, a new gateway in drug delivery systems (DDSs)

Afzal

Ikram

Ali

et al. 2020

Mater. Res. Express

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“…Currently, nanomedicine is a field that has great interest in the scientific community [1], since it has found application in many areas of science such as medical imaging [2], tumor targeting [3], drug delivery [4,5], and biosensors [6], among others. Particularly, nanoparticles have been widely studied for medical purposes; however, the main problem consists in finding the materials with optimal biocompatibility [7].…”

Section: Introductionmentioning

confidence: 99%

Polyethylene Glycol-Coated Gold Nanoparticles as DNA and Atorvastatin Delivery Systems and Cytotoxicity Evaluation

Zamora-Justo

Abrica-González

Vázquez-Martínez

et al. 2019

Journal of Nanomaterials

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The application of nanoscience and nanotechnology in medicine has been useful in the diagnosis, monitoring, and treatment of many diseases. Gold nanoparticles are commonly used for medical imaging studies, biosensors, drug delivery systems, and gene therapy. It has been reported that nanoparticles coated with specific polymers improve the biocompatibility and stability and decrease the cytotoxicity of the nanoparticles. In this work, we performed transfection studies of gold nanoparticles coated with polyethylene glycol, synthetized by two different methods, in a human embryonic kidney cell culture (HEK 293), by using plasmids pSV-β-Gal and pIRES2-EGFP. In addition, we also evaluated the cell uptake of a fluorescent drug (atorvastatin) using the synthetized gold nanoparticles as carriers. Furthermore, the study of cell viability after the interaction between these cells and the nanoparticles was performed. It was shown that the polyethylene glycol-coated gold nanoparticles presented transfection efficiency and cell uptake greater than 45% in each case. These results suggest that the synthetized gold nanoparticles coated with polyethylene glycol could be used successfully and safely as DNA and drug delivery systems.

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“…Dox-DNA-AuNP was synthesized similar to the procedure previously reported by us [16]. There were three steps for the preparation of Dox-DNA-AuNPs; (i) synthesis of AuNPs, (ii) surface modification of AuNPs with the binding DNA, and (iii) Dox loading to the DNA-AuNP.…”

Section: Synthesis Of Dox-dna-aunpmentioning

confidence: 99%

“…Conventional chemotherapy has limitations with a lack of solubility in an aqueous solution, side effects at high-doses, and a short bloodstream circulation half-life [4][5][6]. To overcome these limitations, many approaches using nanoparticles for the drug delivery carrier, such as liposomes [7][8][9], dendrimers [10,11], silicon nanoparticles (SiNPs) [12,13], and gold nanoparticles (AuNPs) [14][15][16][17] have been proposed. Among those nanoparticles, the AuNPs have some advantages as the drug delivery carrier, such as that it is easy to synthesize with controlled size and shape, simple surface chemistry, and high biocompatibility [18,19].…”

Section: Introductionmentioning

confidence: 99%

In Vivo and In Vitro Anticancer Activity of Doxorubicin-loaded DNA-AuNP Nanocarrier for the Ovarian Cancer Treatment

Lee

Kim

et al. 2020

Cancers

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In this study, we have determined the anticancer activity of doxorubicin (Dox)-loaded DNA/gold nanoparticle (AuNP) nanocarrier (Dox-DNA-AuNP) for the treatment of ovarian cancer. The anticancer effect of Dox-DNA-AuNP was evaluated in vitro using the EZ-Cytox cell viability assay on three human ovarian cancer cell lines, SK-OV-3, HEY A8, and A2780. Dox-DNA-AuNP exhibited outstanding activity with good IC50 values of 4.8, 7.4, and 7.6 nM for SK-OV-3, HEY A8, and A2780, respectively. In vivo evaluation further demonstrated the superior anticancer effects of Dox-DNA-AuNP by inhibiting tumor growth compared to free Dox in an established SK-OV-3 xenograft mice model. Dox-DNA-AuNP showed about a 2.5 times higher tumor growth inhibition rate than free Dox. Furthermore, the immunohistochemical analysis of Ki67 antigen expression showed the lowest number of proliferative cells in the ovarian tumor tissue treated with Dox-DNA-AuNP. These results suggest Dox-DNA-AuNP might be a potential effective agent in ovarian cancer chemotherapy.

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Doxorubicin-loaded oligonucleotide conjugated gold nanoparticles: A promising in vivo drug delivery system for colorectal cancer therapy

Cited by 84 publications

References 45 publications

Enhanced drug efficiency of doped ZnO–GO (graphene oxide) nanocomposites, a new gateway in drug delivery systems (DDSs)

Enhanced drug efficiency of doped ZnO–GO (graphene oxide) nanocomposites, a new gateway in drug delivery systems (DDSs)

Polyethylene Glycol-Coated Gold Nanoparticles as DNA and Atorvastatin Delivery Systems and Cytotoxicity Evaluation

In Vivo and In Vitro Anticancer Activity of Doxorubicin-loaded DNA-AuNP Nanocarrier for the Ovarian Cancer Treatment

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