Doxorubicin‐Loaded Magnetic Silk Fibroin Nanoparticles for Targeted Therapy of Multidrug‐Resistant Cancer

Tian, Ye; Jiang, Xuejiao; Chen, Xin; Shao, Zhengzhong; Yang, Wuli

doi:10.1002/adma.201403562

Cited by 230 publications

(154 citation statements)

References 34 publications

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“…8C) [47,48]. It is noted that the body weight of the group treated with DOX-loaded Dex/Chol-PBA remained insignificantly changed in contrast to the distinct decline detected for the group with the treatment of free DOX, indicating the significantly lowered systemic toxicity of the former.…”

Section: In Vivo Anti-tumor Evaluationcontrasting

confidence: 52%

Efficient nuclear drug translocation and improved drug efficacy mediated by acidity-responsive boronate-linked dextran/cholesterol nanoassembly

et al. 2015

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Section: In Vivo Anti-tumor Evaluationcontrasting

confidence: 52%

Efficient nuclear drug translocation and improved drug efficacy mediated by acidity-responsive boronate-linked dextran/cholesterol nanoassembly

et al. 2015

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“…Silk fibroin protein from silkworm cocoons (referred to hereon as silk) has been studied for the release of a variety of therapeutic small molecules [20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32]. Chemotherapy agents such as doxorubicin and platinum-based drugs reversibly bind to silk resulting in sustained release in vitro and in vivo [26, 27, 28, 29, 30, 31, 32].…”

Section: Introductionmentioning

confidence: 99%

Modulation of vincristine and doxorubicin binding and release from silk films

Coburn

Kaplan

2015

Journal of Controlled Release

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Sustained release drug delivery systems remain a major clinical need for small molecule therapeutics in oncology. Here, mechanisms of small molecule interactions with silk protein films were studied with cationic oncology drugs, vincristine and doxorubicin, with a focus on hydrophobicity (non-ionic surfactant) and charge (pH and ionic strength). Interactions were primarily driven by charge interactions between the positively charged drugs and the negatively charged groups within the silk films. Exploiting chemical modifications of silk further modulated the drug interactions in a controlled fashion. Increasing anionic side groups via carboxylate- and sulfonate-modifications of tyrosine side chains in the silk protein using diazonium coupling chemistry, increased drug binding and altered drug release. The effects of silk film protein crystallinity, beta sheet content, on drug binding and release was also explored. Lower crystallinity supported more rapid drug binding when compared to higher crystalline silk films. The drug release kinetics were governed by the protonation state of vincristine and doxorubicin and were tunable based on silk crystallinity and chemistry. These studies depict an approach to characterize small molecule-silk protein interactions and methods to tune drug binding and release kinetics from this protein delivery matrix.

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“…Dendritic cell-derived exosomes loaded with doxorubicin and engineered to express a targeting protein were recently shown to inhibit breast cancer in vitro and in vivo, with reduced toxicity compared with native doxorubicin. Further, the anti-cancer activity of doxorubicin encapsulated in targeted exosomes was superior to that of free doxorubicin and doxorubicin delivered in untargeted exosomes [68]. …”

Section: Exploiting Exosomes To Facilitate the Treatment Of Ovarian Cmentioning

confidence: 99%

The biological significance and clinical applications of exosomes in ovarian cancer

Dorayappan¹,

Wallbillich²,

Cohn

et al. 2016

Gynecologic Oncology

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Exosomes are nano-sized (20–100 nm) vesicles released by a variety of cells and are generated within the endosomal system or at the plasma membrane. There is emerging evidence that exosomes play a key role in intercellular communication in ovarian and other cancers. The protein and microRNA content of exosomes has been implicated in various intracellular processes that mediate oncogenesis, tumor spread, and drug resistance. Exosomes may prime distant tissue sites for reception of future metastases and their release can be mediated by the tumor microenvironment (e.g., hypoxia). Ovarian cancer-derived exosomes have unique features that could be leveraged for use as biomarkers to facilitate improved detection and treatment of the disease. Further, exosomes have the potential to serve as targets and/or drug delivery vehicles in the treatment of ovarian cancer. In this review we discuss the biological and clinical significance of exosomes relevant to the progression, detection, and treatment of ovarian cancer.

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Doxorubicin‐Loaded Magnetic Silk Fibroin Nanoparticles for Targeted Therapy of Multidrug‐Resistant Cancer

Cited by 230 publications

References 34 publications

Efficient nuclear drug translocation and improved drug efficacy mediated by acidity-responsive boronate-linked dextran/cholesterol nanoassembly

Efficient nuclear drug translocation and improved drug efficacy mediated by acidity-responsive boronate-linked dextran/cholesterol nanoassembly

Modulation of vincristine and doxorubicin binding and release from silk films

The biological significance and clinical applications of exosomes in ovarian cancer

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