Doxorubicin-Loaded Liposomes: Enhancing the Oral Bioavailability By Modulation of Physicochemical Characteristics

Daeihamed, Marjan; Haeri, Azadeh; Ostad, Seyed Nasser; Akhlaghi, Masoud Faghih; Dadashzadeh, Simin

doi:10.2217/nnm-2017-0007

Cited by 39 publications

(13 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Liposomes are nanoparticle lipid vesicles that are composed of continuous bilayers of phospholipids surrounding an aqueous phase; they have been investigated as drug-delivery systems for improved targeted delivery of therapeutic agents ( 10 ). Doxorubicin-loaded liposomes have been demonstrated to enhance the oral bioavailability of drugs by modulation of their physicochemical characteristics ( 11 ). In a previous study, doxorubicin-loaded polyethylene glycosylated liposomes were accumulated and retained in the targeted site, and it was reported that such liposome complexes increased the therapeutic efficacy of drugs, thus providing a promising therapeutic approach ( 10 ).…”

Section: Discussionmentioning

confidence: 99%

Cellular viability and osteogenic differentiation potential of human gingiva‑derived stem cells in 2D culture following treatment with anionic, cationic, and neutral liposomes containing doxorubicin

Lee

Son

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

The effects of doxorubicin, particularly doxorubicin liposome, on stem cells have remained to be fully elucidated. The aim of the present study was to evaluate the effects of anionic, cationic and neutral liposomes loaded with doxorubicin on the viability and osteogenic differentiation potential of human gingiva-derived stem cells in two-dimensional culture. Doxorubicin-loaded liposomes were prepared using the traditional thin-lipid-film hydration method. Stem cells were seeded on a culture plate and maintained in osteogenic media. The morphology of the stem cells was observed under an inverted microscope. The number of viable cells was determined using a Cell-Counting Kit-8 assay. The alkaline phosphatase activity was assessed and Alizarin Red S staining was performed to evaluate osteogenic differentiation. A higher concentration of doxorubicin caused noticeable changes in the morphology of the stem cells. Decreases in cellular viability were observed after applying doxorubicin. The application of doxorubicin, particularly at higher concentrations, produced a noticeable decrease in alkaline phosphatase activity and Alizarin Red S staining. The present study indicated that application of doxorubicin with or without liposomes reduced the cellular viability and osteogenic differentiation. Among the different treatments, the doxorubicin-loaded cationic liposomes induced the strongest reduction in the cellular viability and osteogenic differentiation in the stem cell culture.

show abstract

Section: Discussionmentioning

confidence: 99%

Cellular viability and osteogenic differentiation potential of human gingiva‑derived stem cells in 2D culture following treatment with anionic, cationic, and neutral liposomes containing doxorubicin

Lee

Son

et al. 2018

Exp Ther Med

View full text Add to dashboard Cite

show abstract

“…Pegylation, a technique originally developed for extending drug half-life in blood 93 , has also found applications in the oral delivery of liposomes43., 69., 94., 95., 96.. Pegylation of DPPC and PC liposomes significantly enhances the oral bioavailability of recombinant human epithelial growth factor (rhEGF), which was ascribed by the authors to suppression of enzymatic degradation by coating with PEG 95 .…”

Section: Recent Advances In Modulating Liposomes For Oral Drug Deliverymentioning

confidence: 99%

Adapting liposomes for oral drug delivery

Lü

et al. 2019

Acta Pharmaceutica Sinica B

450

250

View full text Add to dashboard Cite

Liposomes mimic natural cell membranes and have long been investigated as drug carriers due to excellent entrapment capacity, biocompatibility and safety. Despite the success of parenteral liposomes, oral delivery of liposomes is impeded by various barriers such as instability in the gastrointestinal tract, difficulties in crossing biomembranes, and mass production problems. By modulating the compositions of the lipid bilayers and adding polymers or ligands, both the stability and permeability of liposomes can be greatly improved for oral drug delivery. This review provides an overview of the challenges and current approaches toward the oral delivery of liposomes.

show abstract

“…According to our previous experiments and also the literature-based data, 20 positively charged carriers may be more desirable for oral drug delivery. To take possible advantage of this issue, T80 formulation which showed the highest oral bioavailability was induced with some grades of positive charge by adding 4 mol% of STA.…”

Section: Effect Of Surface Positive Chargementioning

confidence: 68%

“…The nature of the surfactant is an important factor affecting physicochemical characteristics of niosomes, namely, bilayer rigidity, particle size, stability and drug release rate, therefore, it is expected to play an important role in in vivo behavior of these drug delivery systems. Motivated by the advantages associated with niosomal drug delivery systems and also our previous results on the desirable influence of positively charged liposomes in improving oral drug absorption of a BCS III drug, 20 the aim of this study was to investigate the impact of surfactant composition of niosomal formulations as well as positive surface charge of vesicles on the oral absorption of repaglinide (REG) as a BCS class II model drug. REG is an effective orally administered antihyperglycemic drug and is widely used in the treatment of type II diabetes mellitus.…”

Section: Introductionmentioning

confidence: 99%

<p>The Impact of Surfactant Composition and Surface Charge of Niosomes on the Oral Absorption of Repaglinide as a BCS II Model Drug</p>

Yaghoobian¹,

Haeri²,

Bolourchian³

et al. 2020

IJN

Self Cite

View full text Add to dashboard Cite

Background Niosomes, bilayer vesicles formed by the self-assembly of nonionic surfactants, are receiving increasing attention as potential oral drug delivery systems but the impact of niosomal formulation parameters on their oral capability has not been studied systematically. The aim of this study was to investigate the impact of surfactant composition and surface charge of niosomes in enhancing oral bioavailability of repaglinide (REG) as a BCS II model drug. Methods Niosomes (13 formulations) from various nonionic surfactants having HLB in the range of 4–28 (Tweens, Spans, Brijs, Myrj, poloxamer 188, TPGS and Labrasol) were prepared and characterized concerning their loading efficiency, hydrodynamic diameter, zeta potential, drug release profile, and stability. The oral pharmacokinetics of the selected formulations were studied in rats (8 in vivo groups). Results The results revealed that type of surfactant markedly affected the in vitro and in vivo potentials of niosomes. The C max and AUC values of REG after administration of the selected niosomes as well as the drug suspension (as control) were in the order of Tween 80> TPGS> Myrj 52> Brij 35> Span 60≈Suspension. Adding stearyl amine as a positive charge-inducing agent to the Tween 80-based niosomes, resulted in an additional increase in drug absorption and values of AUC and C max were 3.8- and 4.7-fold higher than the drug suspension, respectively. Conclusion Cationic Tween 80-based niosomes may represent a promising platform to develop oral delivery systems for BCS II drugs.

show abstract

Doxorubicin-Loaded Liposomes: Enhancing the Oral Bioavailability By Modulation of Physicochemical Characteristics

Abstract: Oral absorption is highly dependent on liposomal properties, and optimum formulations are effective for low-permeability drugs.

Cited by 39 publications

References 51 publications

Cellular viability and osteogenic differentiation potential of human gingiva‑derived stem cells in 2D culture following treatment with anionic, cationic, and neutral liposomes containing doxorubicin

Cellular viability and osteogenic differentiation potential of human gingiva‑derived stem cells in 2D culture following treatment with anionic, cationic, and neutral liposomes containing doxorubicin

Adapting liposomes for oral drug delivery

<p>The Impact of Surfactant Composition and Surface Charge of Niosomes on the Oral Absorption of Repaglinide as a BCS II Model Drug</p>

Contact Info

Product

Resources

About