Doxorubicin-loaded hydrogen peroxide self-providing copper nanodots for combination of chemotherapy and acid-induced chemodynamic therapy against breast cancer

Application and prospect of ROS-related nanomaterials for orthopaedic related diseases treatment

“…Chemodynamic therapy is a new treatment for cancer in recent years, which is mainly based on Fenton response or Fenton-like response ( Li et al, 2021b ). Based on the slightly acidic environment of the tumor area, chemodynamic therapeutic nanoparticles can rapidly generate large amounts of ROS by Fenton reaction or Fenton-like reaction, without the need for activation by external energy (such as laser, ultrasound, etc. )…”

Macrophage-Mimic Hollow Mesoporous Fe-Based Nanocatalysts for Self-Amplified Chemodynamic Therapy and Metastasis Inhibition via Tumor Microenvironment Remodeling

“…3−5 In recent years, chemodynamic therapy (CDT), as an emerging tumor therapeutic strategy, has attracted increasing attention in the breast cancer treatment due to its advantages of high specificity and negligible drug resistance. 6 Specifically, CDT utilizes Fenton-active agents to catalyze tumor-overexpressed H 2 O 2 into highly oxidative •OH, thereby inducing cell apoptosis/ferroptosis and ultimately inhibiting tumor growth. 7,8 Starting from the Fe 3 O 4 nanoparticle with Fenton activity to catalyze H 2 O 2 into •OH that was discovered in 2007, 9 a variety of Fe-based nanomaterials have been extensively explored in CDT.…”

“…Breast cancer is the most common malignancy and the primary cause of cancer-associated deaths among women worldwide. , Despite many treatment strategies, including chemotherapy, radiotherapy, phototherapy, and surgery, that have been developed to conquer breast cancer, the cure rate is still unsatisfactory because of the treatment resistance and metastasis. − In recent years, chemodynamic therapy (CDT), as an emerging tumor therapeutic strategy, has attracted increasing attention in the breast cancer treatment due to its advantages of high specificity and negligible drug resistance . Specifically, CDT utilizes Fenton-active agents to catalyze tumor-overexpressed H 2 O 2 into highly oxidative •OH, thereby inducing cell apoptosis/ferroptosis and ultimately inhibiting tumor growth. , Starting from the Fe 3 O 4 nanoparticle with Fenton activity to catalyze H 2 O 2 into •OH that was discovered in 2007, a variety of Fe-based nanomaterials have been extensively explored in CDT.…”

A Multifunctional Nanoplatform Based on Fenton-like and Russell Reactions of Cu, Mn Bimetallic Ions Synergistically Enhanced ROS Stress for Improved Chemodynamic Therapy

“…Chemodynamic therapy (CDT) is a recently developed cancer treatment strategy based on the Fenton/Fenton-like reactions to trigger the production of highly cytotoxic hydroxyl radicals ( • OH) from H 2 O 2 . − CDT shows minimal invasiveness through a highly specific tumor response and controlled spatiotemporal effects to generate reactive oxygen species (ROS). − CDT does not rely on exogenous stimulation and energy input, and it gets rid of the flaws of photodynamic therapy such as limited treatment depth, heavy reliance on light sources, and oxygen concentration. − However, the low ROS generation rate of many CDT agents has impeded their clinical application. , The overexpression of glutathione (GSH) in tumor cells would also deplete the cytotoxic ROS and lead to a reduction in CDT efficacy. , Moreover, far from killing the tumor cells, the insufficient • OH generated by an inefficient Fenton reaction would cause a risk of stimulating cancer cell metastasis. , Although the intracellular H 2 O 2 concentration in tumor cells has been reported to be high, it still does not meet CDT requirements . Many researchers have made efforts to increase intracellular H 2 O 2 concentrations, such as exogenously carrying H 2 O 2 , and producing H 2 O 2 in situ . − However, it is complicated to prepare the agent that is able to carry H 2 O 2 , and the risk of leakage in the circulation is inevitable.…”