Doxorubicin-intercalated nano-hydroxyapatite drug-delivery system for liver cancer: An animal model

Kundu, Biswanath; Ghosh, Dibakar; Sinha, M. K.; Sen, P S; Balla, Vamsi Krishna; Das, Nirmalendu; Basu, Debabrata

doi:10.1016/j.ceramint.2013.05.074

Cited by 83 publications

(52 citation statements)

References 31 publications

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“…Hydroxyapatite [HA, Ca 10 (PO 4 ) 6 (OH) 2 ] is one such bioactive material and attracted greatest interest for use as coatings on metallic implants to impart bioactivity . HA is also well known for its excellent biocompatibility, good bioactivity, and bone bonding properties and therefore extensively used in the replacement of bone tissue, soft tissues, targeted drug delivery, bioimaging and diagnosis . Although synthetic HA possess good biological properties, it suffers from shortcomings such as low mechanical strength and fracture toughness, low dissolution rate, and lack of osteoinduction.…”

Section: Introductionmentioning

confidence: 99%

In vitro cytotoxicity and ion release of multi‐ion doped hydroxyapatite

Reger

Kundu

Balla

et al. 2018

Int J Applied Ceramic Tech

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Multi-ion doped hydroxyapatite (HA) is gaining more attention due to its potential in enhancing multifunctional biological, structural, and mechanical properties for orthopedic and dental applications. In this study, HA doped with multiple cations (Sr +2 , Zn +2 , Ag + ) and anion (F − ) was prepared by high-energy ball milling. Sintered HA samples were evaluated for their in vitro cytocompatibility, ion release, and bioactivity. The composition of multi-ion doped HA was optimized usingDesign of experiments (DOE). Our analysis showed that the contribution of each dopant on cell proliferation changes with culture duration. During first 3 days, F − exhibited strongest influence and during 7-day proliferation Sr +2 and Ag + had maximum influence. Binary ion doping found to have strong interaction on cell proliferation, while the ternary and quaternary ion doping did not show any interactions. In general, up to twofold increase in the cell viability was achieved with ternary and quaternary ion doping consisting of Sr +2 , Zn +2 , Ag + and F − .Although large number of compositions has been identified to exhibit better in vitro cell viability than pure HA, for enhanced long-term cytocompatibility the compositions of multi-ion doped HA would be 2.5Sr-2.5Zn-2.5Ag, 2.5Sr-5Zn-2.5Ag, and 5Sr-2.5Zn-2.5Ag with up to 5 wt% F. K E Y W O R D Sbioactivity, doped HA, in vitro, ion release, multi-ion

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Section: Introductionmentioning

confidence: 99%

In vitro cytotoxicity and ion release of multi‐ion doped hydroxyapatite

Reger

Kundu

Balla

et al. 2018

Int J Applied Ceramic Tech

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Section: Nanoparticle Delivery Drug Deliverymentioning

confidence: 88%

“…After thorough in vitro characterization, these nano-HAP particles were loaded/intercalated with DOX (50-60% encapsulation efficiency), and thorough characterization of the size, shape and morphology of the particles was performed. The results indicate that this new formulation is an efficient, safe and reliable treatment method for HCC [17].In 2014, Ye Wang and his co-workers reported a new nanocarrier called Anodic Alumina Nanotubes (AANTs) for potential cancer therapy. AANTs were electrochemically engineered by a unique pulse anodization process, which enables precise control of the nanotube geometry, and used here as nanocarriers for drug delivery [18].…”

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confidence: 99%

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Nanotechnology, as a cutting-edge field, has a wide range of application and clear industrial prospect in monitoring and treatment of cancer, especially in the aspect of drug delivery and drug resistance.The nanotechnology was defined as research with materials at the nanoscales, which are at dimensions between approximately 1 and 100nm and had been moved forward through multidisciplinary collaborations among many disciplines including chemistry, physics, biology and engineering. Now nanotechnology has played an important role in generating innovative solutions of the central issues of cancer treatment, for example, how to detect tumors earlier, how to target cancer cells accurately and how to improve the radiotherapy treatments. Nanotechnology can also be used to develop highly sensitive diagnostic devices, allowing treatment to begin before the onset of metastasis and resulting in improved outcomes for the patients [1].Nanotechnology mainly contains seven branches: nanometer system of physics, nanochemical, nanomaterials science, nanobiology, nanoelectronics, nanoprocessing and nanomechanics. In the case of nanomaterials, because of their size, nanoscale materials have some different chemical and physical properties from bulk material. Researchers have capitalized on these qualities of nanomaterials for effective improvements in drug delivery, cancer cell targeting via protein and small molecule binding, intracellular drug release, ex vivo diagnostic applications, imaging, and combination therapies including theranostic integration of molecular imaging with drug delivery [2]. Nanoparticle formulations can reduce or eliminate systemic toxicities by delivering drugs specifically to cancerous tissues through size mediated passive targeting and physiologically mediated active targeting; they can improve early detection through targeted delivery of molecular imaging agents to tumors for improved diagnostic imaging and intraoperative imaging to guide surgical removal of cancerous cells; they can address drug resistance through the delivery of multiple drugs or complimentary treatments such as RNA interference [1].Nanomedicines have been investigated for their application in anticancer therapies to improve drug delivery, increase the efficacy of treatment, reduce side effects, and overcome drug resistance. The number of studies published under the research topics of "nanomedicine", "nanoscience" and "nanotechnology" has increased exponentially over the past decade. As more nanostructures were discovered and their potentials were better understood, the number of publications increased and reached its peak in 2011. Currently, the knowledge base of nanoparticles is still expanding with an emphasis on safety and efficacy [3]. Cancer and Cancer's TherapyOver the past twenty years the incidence of cancer has a gradually upward trend because of many factors like environment pollution, air, water and some chemical products. But a significant reduction in the death rates associated with cancer is due to the improvements of ea...

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“…nHA NPs coated with a fluorescent dye are great carriers for applications such as imaging or for photodynamic therapy. The development of future technologies offers many interesting avenues of new research including the development of ceramic particles incorporating drugs such as doxorubicin [55] that are required to be slow-released over several days or months. The time of release could be controlled by the CaP composite having varying times of degradation.…”

Section: Nano-hydroxyapatite (N-ha)mentioning

confidence: 99%