Doxorubicin-induced mitophagy contributes to drug resistance in cancer stem cells from HCT8 human colorectal cancer cells

Yan, Chen; Luo, Lan; Guo, Chang‐Ying; Goto, Shinji; Urata, Yoshishige; Shao, Jianghua; Li, Tao‐Sheng

doi:10.1016/j.canlet.2016.11.018

Cited by 130 publications

(103 citation statements)

References 36 publications

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“…Autophagy can act as a survival mechanism for cancer cells in response to various stresses (15)(16)(17), but the role of canonical autophagy in cancer remains unclear (5,18,19). Therefore, how about mitophagy in cancer?…”

Section: Biological Role Of Mitophagymentioning

confidence: 99%

“…Mitophagy is causally linked to various physiological processes and diseases, for example defective mitophagy will impair survival of memory natural killer cells, conferring Parkinson's disease and cardiac defects (13,20,21). Furthermore, evidence indicates that dysfunction of mitophagy also promotes tumorigenesis and neoplastic progression (4,5,14). Guo et al reported that the induction of mitophagy in macrophages prevents the progression of colitis-associated cancer (22).…”

Section: Biological Role Of Mitophagymentioning

confidence: 99%

“…chloroquine, hydrochloroquine) have entered dozens of clinical studies on anticancer therapy (See https://clinicaltrials.gov/ct2/results?term=autophagy+ and+cancer). There is great interest in manipulating mitophagy in order to improve cancer therapy, while these strategies are considerably confusing (5,24,25). The functional outcome of mitophagy-induced cell death or survival dependent on cancer therapy relies on different therapeutic treatments and cell types (Figure 2).…”

Section: Manipulating Mitophagy As a Potential Target For Cancer Therapymentioning

confidence: 99%

“…Mitophagy, a selective autophagic process, has been shown to promote tumorigenesis and cell survival in various types of tumors by removing abnormal mitochondria (4,5). The toxicity of most chemotherapeutic agents is partially attribute to the induction of mitochondrial dysfunction and oxidative stresses (6,7).…”

mentioning

confidence: 99%

“…The toxicity of most chemotherapeutic agents is partially attribute to the induction of mitochondrial dysfunction and oxidative stresses (6,7). Thus, the rapid clearance of damaged mitochondria by mitophagy is thought to mediate drug resistance in cancer cells (5). In addition, excessive mitochondrial clearance may induce cell metabolic disorders and cell death (8).…”

mentioning

confidence: 99%

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Dual Role of Mitophagy in Cancer Drug Resistance

Yan

2018

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Section: Biological Role Of Mitophagymentioning

confidence: 99%

Section: Biological Role Of Mitophagymentioning

confidence: 99%

Section: Manipulating Mitophagy As a Potential Target For Cancer Therapymentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Dual Role of Mitophagy in Cancer Drug Resistance

Yan

2018

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Selectively targeting cancer stem cells: Current and novel therapeutic strategies and approaches in the effective eradication of cancer

et al. 2021

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Cancer stem cells (CSCs) are a subgroup of cells in malignant cancers, which possess self-renewal capacity, tumor-initiating capability, and pluripotency, as well as being responsible for tumor maintenance, metastasis, relapse, and chemoresistance. The treatment modalities previously established for cancer included surgery, chemotherapy, and radiotherapy. The majority of tumor cells of non-CSCs could be eradicated using conventional chemotherapy and radiotherapy. Therefore, novel and promising therapeutic strategies that selectively target CSCs are of great importance. In this review, we described different therapeutic strategies such as immunotherapy, metabolism-based therapeutic strategies, and additional potential therapeutic approaches (targeting micro-RNAs [miRNAs], histone deacetylase, and DNA methyl transferase) against CSCs. Taken together, due to the inefficiency of anticancer single therapies, targeting CSCs through their metabolism and using immunotherapy and miRNAs besides classical chemo-and radiotherapy may exert better therapeutic effects.

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Formosanin C suppresses cancer cell proliferation and migration by impeding autophagy machinery

Chu

Lin

Liu

et al. 2023

The Kaohsiung J of Med Scie

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Formosanin C (FC) is a natural compound extracted from Paris formosana Hayata with anticancer activity. FC induces both autophagy and apoptosis in human lung cancer cells. FC-induced depolarization of mitochondrial membrane potential (MMP) may trigger mitophagy. In this study, we clarified the effect of FC on autophagy, mitophagy, and the role of autophagy in FC-related cell death and motility. We found FC caused the continuous increase of LC3 II (representing autophagosomes) from 24 to 72 h without degradation after treatment of lung and colon cancer cells, indicating that FC blocks autophagic progression. In addition, we confirmed that FC also induces early stage autophagic activity. Altogether, FC is not only an inducer but also a blocker of autophagy progression. Moreover, FC increased MMP accompanied by overexpression of COX IV (mitochondria marker) and phosphorylated Parkin (p-Parkin, mitophagy marker) in lung cancer cells, but no colocalization of LC3 with COX IV or p-Parkin was detected under confocal microscopy. Moreover, FC could not block CCCP (mitophagy inducer)-induced mitophagy. These results imply that FC disrupts mitochondria dynamics in the treated cells, and the underlying mechanism deserves further exploration. Functional analysis reveals that FC suppresses cell proliferation and motility through apoptosis and EMT-related pathway, respectively. In conclusion, FC acts as an inducer as well as a blocker of autophagy that results in cancer cell apoptosis and decreased motility. Our findings shed the light on the development of combined therapy with FC and clinical anticancer drugs for cancer treatment.

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Doxorubicin-induced mitophagy contributes to drug resistance in cancer stem cells from HCT8 human colorectal cancer cells

Cited by 130 publications

References 36 publications

Dual Role of Mitophagy in Cancer Drug Resistance

Dual Role of Mitophagy in Cancer Drug Resistance

Selectively targeting cancer stem cells: Current and novel therapeutic strategies and approaches in the effective eradication of cancer

Formosanin C suppresses cancer cell proliferation and migration by impeding autophagy machinery

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