2018
DOI: 10.1016/j.tiv.2018.05.001
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Doxorubicin-induced mitophagy and mitochondrial damage is associated with dysregulation of the PINK1/parkin pathway

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Cited by 142 publications
(92 citation statements)
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“…Dox was reported to inhibit cardiac mitophagy because of the sequestration of parkin by p53 that led to decreased mitochondrial translocation of parkin and reduced mitochondria incorporation into autophagic vacuoles (34). In contrast, Dox was also shown to induce mitophagy in cardiomyocytes as evidenced by increased mitochondrial translocation of phosphatase and tensin homolog-induced kinase 1 and parkin and increased colocalization of LC3 with mitochondria (35). These inconsistent results may be in part caused by the methods used to quantify mitophagy.…”
Section: Discussionmentioning
confidence: 99%
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“…Dox was reported to inhibit cardiac mitophagy because of the sequestration of parkin by p53 that led to decreased mitochondrial translocation of parkin and reduced mitochondria incorporation into autophagic vacuoles (34). In contrast, Dox was also shown to induce mitophagy in cardiomyocytes as evidenced by increased mitochondrial translocation of phosphatase and tensin homolog-induced kinase 1 and parkin and increased colocalization of LC3 with mitochondria (35). These inconsistent results may be in part caused by the methods used to quantify mitophagy.…”
Section: Discussionmentioning
confidence: 99%
“…Raw images of AdDsRed-infected H9c2 cells or adult mouse cardiomyocytes were obtained with confocal microscopy. Images were optimized for morphometric analysis using methods as previously described (34,35). Using ImageJ, red-green-blue images were converted to 8 bit and were contrast enhanced.…”
Section: Mitochondrial Morphology Analysismentioning
confidence: 99%
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“…PTEN-induced putative kinase protein 1 (PINK1) /Parkin pathway is critical for regulating mitophagy and mitochondrial damage, its activation promotes mitophagy and protects cells from death and apoptosis [16]. Previous studies showed that ROS induced by cadmium promoted autophagy and mitophagy by regulating PINKl/Parkin pathway in mice [17, 18].…”
Section: Introductionmentioning
confidence: 99%
“…The mechanisms of anthracycline-induced cardiomyopathies include endoplasmic reticulum stress, calcium dysregulation, activation of immune, impairment of progenitor cells, and some other parameters [35; 36]. To date, the most widely cited and accepted mechanism is oxidative stress caused by ROS production [37][38][39][40]. Koleini imaging tracer mainly localized in mitochondria.…”
Section: Discussionmentioning
confidence: 99%