Doxorubicin/heparin composite nanoparticles for caspase-activated prodrug chemotherapy

Fabrication and characterization of a novel self-assembling micelle based on chitosan cross-linked pectin–doxorubicin conjugates macromolecular pro-drug for targeted cancer therapy

“…It revealed that the treated groups had signicantly lower mean tumor volume (p < 0.01) than that of the control groups. In addition, compared to the initial tumor volume (approximately 200 mm 3 M. Although the tumor growth was inhibited by free DOX treatment, the body weight of this group dramatically decreased compared to other groups (Fig. 7B).…”

“…18,19 Various polymer-based drug delivery systems with good biocompatibility and biodegradability have been developed in order to reduce side effects and improve the therapeutic. 3,16 There are several types of polymer-based drug delivery systems that could be exploited for the relevant purposes, including polymer-drug conjugates, [20][21][22] micelles, 23,24 and vesicles. [25][26][27] Pectin-doxorubicin conjugated macromolecule prodrug (PDC-M) nanoparticles, a novel amphiphilic core-shell micelle, was successfully synthesized.…”

Heparin-Based Nanoparticles: An Overview of Their Applications

“…Caspases are proteases that control the death and inflammation of cells; they execute apoptosis, and so in the case of this nanosystem, an amplified apoptosis is induced. Murine squamous cell carcinoma (SCC-7) cancer cells were used in this study [45]. Zhang et al developed an interesting system which comprises two anticancer drugs, ATRA (all trans retinoic acid) and DOX (doxorubicin), the first one being conjugated to LMWH (low molecular weight heparin) and the second one loaded physically, such system was named as DOX-loaded LMWH-ATRA.…”

Folate chitosan conjugated doxorubicin and pyropheophorbide acid nanoparticles (FCDP–NPs) for enhance photodynamic therapy

“…It has been widely reported that DOX mainly acted in the site of cell nucleus. 29,30 Therefore, the introduction of DOX to FCDP-NPs could improve the nucleus targetability to some degree.…”

“…For example, doxorubicin (DOX) used as a prodrug to formulated nanoparticles for NIR-triggered high-efficient photodynamic and chemocascade therapy. 29,30 Considering the advantages of FA, CS and DOX mentioned above, in this paper, we designed and prepared folate chitosan conjugated doxorubicin and pyropheophorbide acid nanoparticles (FCDP-NPs) to enhance photodynamic therapy of PPa, which is the second generation photosensitizer with large molar extinction coefficient to transfer the energy for sufficient ROS generation, and a larger absorption wavelength (683 nm, located in therapeutic window) ensuring the deep penetration of light into tissues, being suitable for the photodynamic therapy. In our strategy, we used folic acid as a specic substance for tumor target, chitosan as the matrix of nanoparticles, PPa as a photosensitizer and DOX as a chemotherapy drug to improve the PDT activities.…”