Doxorubicin-encapsulated thermosensitive liposomes modified with poly(N-isopropylacrylamide-co-acrylamide): Drug release behavior and stability in the presence of serum

Han, Hee Dong; Shin, Byung Cheol; Choi, Ho‐Suk

doi:10.1016/j.ejpb.2005.07.006

Cited by 128 publications

(59 citation statements)

References 22 publications

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“…Polymers that have been investigated for their use in temperature-sensitive liposome preparations include poly(N-isopropylacrylamide) (Kono et al, 2002), poly(N-iso isopropylacrylamide-co-acrylamide) (Han et al, 2006) and Pluronic F127 (Chandaroy et al, 2001). However, poly(N-isopropylacrylamide) is not biodegradable, and therefore, can result in unwanted side effects associated with polymer accumulation (Sawant and Torchilin, 2010).…”

Section: Stimuli-sensitive Drug Release Strategymentioning

confidence: 99%

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

2016

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Section: Stimuli-sensitive Drug Release Strategymentioning

confidence: 99%

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

2016

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“…It was also observed that [22] cell adhesion, cell growth properties and drug elution from cast NIPAm/N-tBAAm copolymer films were all dependent on the copolymer composition [54,55]. In contrast, by increasing the amount of a hydrophilic monomer AAm in the NIPAm/ AAm copolymers (from a molar ratio of 100:0 to 75:25), the LCST is increased (from 33 to 47 C) [56].…”

Section: Poly(n-isopropylacrylamide) Pnipammentioning

confidence: 91%

Fluorescence Analysis of Thermoresponsive Polymers

Morris

Ryder

2015

Reviews in Fluorescence 2015

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The use of microscale thin polymer films is widespread in biomedical science and engineering, with applications in areas such as tissue engineering, drug delivery, microfluidic devices, bio-adhesion mediators, and bio-actuators. Much attention is devoted to the use of functional polymers that display stimuliresponsive behavior with the intention of providing "smart" coatings. One potential example is the use of thin thermoresponsive polymer films as drug eluting coatings on medical devices, where not only does the polymer function as a drug reservoir but it also acts as a biocompatibility modulator to improve device performance.Often these thin polymer coatings have to be applied to complex geometries, which can cause problems for in-situ analysis. Another important consideration is the fact that these films have large surface area to mass ratios and thus water uptake can be significant. This is serious because coating stability, device efficacy, and long-term storage are influenced by the physiochemical properties of the polymer which are modulated by water content. Thus, there is a need for a rapid, non-contact, non-destructive, analytical method capable of analyzing thermoresponsive polymers in solution, and in-situ of the solid-state on medical devices. Fluorescence spectroscopy based methods can deal with both sample types and provide additional benefits in terms of high sensitivity and low probe concentrations, which provide for minimal sample disruption. This article gives a brief overview of the application of various fluorescence methods for the physicochemical characterization of thermoresponsive polymers such as poly (N-isopropylacrylamide), PNIPAm.

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“…In Vitro Release Kinetics In vitro release kinetics were monitored for EPC/ Chol/PPZ liposomes incorporating the fluorescent markers HPTS (35 mM) and quencher DPX (50 mM) in HEPES buffer (20 mM) before and after a 1-h incubation with 50% (v/v) human serum (Han et al, 2006). SEC was performed to remove nonencapsulated marker/quencher as well as excess serum components.…”

Section: Analysis Of Ph-sensitive Liposomesmentioning

confidence: 99%

Amphiphilic Ionizable Polyphosphazenes for the Preparation of pH‐Responsive Liposomes

Ghattas

Leroux

2008

Polyphosphazenes for Biomedical Applications

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Doxorubicin-encapsulated thermosensitive liposomes modified with poly(N-isopropylacrylamide-co-acrylamide): Drug release behavior and stability in the presence of serum

Cited by 128 publications

References 22 publications

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

Lipid-Based Drug Delivery Systems in Cancer Therapy: What Is Available and What Is Yet to Come

Fluorescence Analysis of Thermoresponsive Polymers

Amphiphilic Ionizable Polyphosphazenes for the Preparation of pH‐Responsive Liposomes

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