Doxorubicin delivery to breast cancer cells with transferrin-targeted carbon quantum dots: An in vitro and in silico study

Mahani, Mohamad; Pourrahmani-Sarbanani, Maryam; Yoosefian, Mehdi; Divsar, Faten; Mousavi, Seyedeh Maral; Nomani, Alireza

doi:10.1016/j.jddst.2021.102342

Cited by 32 publications

(17 citation statements)

References 37 publications

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“…This technique is a potential strategy for designing and fabricating novel electrocatalysts with customizable doping composition and electronic architectures because of its simple synthetic procedure and variable hetero-atom doping. (Mahani et al, 2021). Similarly, Sahoo et al reported hydrothermal fabrication of NiS-CQDs from lime juice for supercapacitor applications with a specific capacity of 880 Fg −1 at a current density of 2 Ag −1 .…”

Section: Hydrothermal/solvothermal Methodsmentioning

confidence: 96%

Recent Advances on Synthesis and Potential Applications of Carbon Quantum Dots

2022

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Fluorescent carbon nanoparticles also termed as carbon quantum dots (CQDs) have attracted so much interest when compared to the traditional semiconductor quantum dots due to their applications in chemical sensing, biomedical imaging, nanotechnology, photovoltaics, light-emitting diodes (LEDs), and electrochemistry. Along with their optical features, CQDs have desired properties such as less toxicity, environmentally friendly nature, inexpensive, and simple preparation processes. In addition, CQDs can have their physical and chemical properties controlled by surface passivation and functionalization. This article provides an account of CQDs because of their distinct characteristics and considerable capacity in diverse applications. The article is categorized into various sections that highlight various synthesis methodologies of CQDs with their advantages/disadvantages and their potential applications in sensors, bio-imaging, drug delivery, solar cells, and supercapacitors. The different applications of CQDs can be demonstrated by controlled synthesis methods. We have also discussed gas sensing applications of CQDs briefly and provided a brief overview of osmotic power generation using CQDs for energy applications.

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Section: Hydrothermal/solvothermal Methodsmentioning

confidence: 96%

Recent Advances on Synthesis and Potential Applications of Carbon Quantum Dots

2022

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“…In the FRET process, NCDs transferred their energy to the quencher AuNPs, and thus, their fluorescence was quenched. It is essential for the FRET process that the donor emission spectrum overlaps the absorption spectrum of the acceptor which expresses a large influence on measured transfer efficiency [ 33 ]. In Figure S2A , the absorption spectrum of the AuNPs overlaps with the emission spectrum of NCDs.…”

Section: Resultsmentioning

confidence: 99%

Ultrasensitive FRET-based aptasensor for interleukin-6 as a biomarker for COVID-19 progression using nitrogen-doped carbon quantum dots and gold nanoparticles

et al. 2022

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A label-free and specific FRET-based interleukin-6 (IL-6) aptasensor was developed using a DNA aptamer modified with nitrogen-doped carbon quantum dots (NCDs) and gold nanoparticles (AuNPs) as a donor-quencher pair. The assayed target was capable of disrupting the donor–acceptor assemblies yielding a concentration-related fluorescence recovery of NCDs ( λ em = 445 nm and λ ex = 350 nm). By designing two different probes, the interaction of DNA aptamers with IL-6 protein was studied using FRET efficiency. It appeared that the sensing probes showed slightly different sensing profiles. One of the aptasensors showed a linear response of 1.5–5.9 pg/mL for IL-6 with a coefficient of determination of R 2 ≥ 0.99 and the a detection limit of 0.82 pg/mL (at S/N = 3). The experimental results indicated that the biosensor can be applied to determine IL-6 in human serum (with recovery of 95.7–102.9%). Due to the high sensitivity, excellent selectivity, and simplicity of the procedure, this strategy represents a promising alternative for IL-6 sensing in clinical applications. Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s00604-022-05570-5.

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“…The nanocarrier at pH = 7.4 showed good stability, and only 18% of the DOX was released within 10 h; however, at pH = 5.2, ca. 50% of the drug was released within 24 h. The DOX-loaded TF-CDs conjugate was also used for cell tracking in MCF-7 cells …”

Section: Cds As a Targeted Nanocarrier For Cancer Treatmentmentioning

confidence: 99%

“…Chemotherapeutics are attached with CDs via covalent or noncovalent bonds; both techniques are significant for drug attachment with CDs due to the existence of numerous intrinsic binding sites including amine, carboxyl, and hydroxyl on their surfaces . These functionalities allow the conjugation of chemotherapeutics on their surface and are able to release the payloads after coming in contact with some definite environment like acidic pH, reactive oxygen species (ROS), reactive sulfur species (RSS), reactive nitrogen species (RNS), and other abundant small molecules present in cancer cells and to prevent the premature release of chemotherapeutics in normal physiological conditions. − Furthermore, it is also possible to simultaneously conjugate drug and targeting ligands on the surface of CDs, which provides receptor targeting capabilities to CDs …”

Section: Cds As a Targeted Nanocarrier For Cancer Treatmentmentioning

confidence: 99%

Review of Carbon Dot-Based Drug Conjugates for Cancer Therapy

Dubey

Dhiman

Koner

2023

ACS Appl. Nano Mater.

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Carbon Dots (CDs) are a class of carbon-based nanostructure known as zero-dimensional nanomaterial and have great potential in the field of targeted chemotherapy. CDs have been extensively explored for bioimaging, sensing, and therapy due to their high quantum yield, low cytotoxicity, high water solubility, good photostability, and tunable excitation wavelength-dependent emission properties. CDs conjugated with various anticancer drugs such as Doxorubicin (DOX), Epirubicin and Temozolomide, Protoporphyrin IX (PpIX), 5-Fluorouracil, Curcumin, Gemcitabine, Methotrexate (MTX), Oxaliplatin, and Cisplatin are explored for chemotherapy applications. These drugs are conjugated with CDs via covalent bond formation such as amide, ester, and hydrazine or with the help of noncovalent electrostatic attraction from opposite charges and hydrogen-bonding interactions. The release of these drug molecules can be controlled with the help of the acidic pH or via highly reactive and abundant small molecular species present in a cancerous environment compared to normal physiological conditions. The CDs-drug conjugate can be specifically released in a targeted manner with the help of a specific substrate attached at the surface and their interaction with overexpressed cell surface receptors. In this review, we demonstrate the application of CDs-drug conjugate toward drug delivery systems for oncology applications.

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Doxorubicin delivery to breast cancer cells with transferrin-targeted carbon quantum dots: An in vitro and in silico study

Cited by 32 publications

References 37 publications

Recent Advances on Synthesis and Potential Applications of Carbon Quantum Dots

Recent Advances on Synthesis and Potential Applications of Carbon Quantum Dots

Ultrasensitive FRET-based aptasensor for interleukin-6 as a biomarker for COVID-19 progression using nitrogen-doped carbon quantum dots and gold nanoparticles

Review of Carbon Dot-Based Drug Conjugates for Cancer Therapy

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