Doxorubicin Delivery into Tumor Cells with Ultrasound and Microbubbles

Escoffre, Jean‐Michel; Piron, Julien; Novell, Anthony; Bouakaz, Ayache

doi:10.1021/mp100397p

Cited by 115 publications

(105 citation statements)

References 34 publications

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“…''Sonoporation'' (117; 2.4 %) has an apparent upward movement in its ranks, from no emergence in 1991-1996 to 9th in 2009-2014. Further, with the introduction of microbubble-assisted ultrasound, a phenomenon called sonoporation has been successfully applied to deliver drugs and genes in vitro and in vivo in a variety of therapeutic application (Ferrara et al 2007;Escoffre et al 2011;Delalande et al 2013). In addition, ''Cavitation'' (139; 2.9 %) in author keywords steadily ranked in the top 11 during all four 6-year periods, which illustrates that ultrasound-induced microbubble cavitation has been an on-going concern (Doida et al 1998;Postema et al 2004;Zhang et al 2013).…”

Section: Author Abstractmentioning

confidence: 99%

“…Figure 9c shows that cell, cancer, drug, gene, liver and myocardial related research are the most common topics in micro/nano-bubble related research (Bax et al 2003;Ferrara et al 2007;Escoffre et al 2011;Delalande et al 2013). Cell-related research has attained a tremendous increase in popularity and dominated the research focus since 2005.…”

Section: Hot Issues and Future Trendsmentioning

confidence: 99%

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A bibliometric analysis of micro/nano-bubble related research: current trends, present application, and future prospects

Zheng

Wang

et al. 2016

Scientometrics

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With great versatile characteristics, micro/nano-bubble related research have attracted much attention due to their extensive applications in the last half century.Researchers not merely focus on their physi-chemical properties, but also aim at their wellcontrolled generation methods and potential adhibition field. It can be expected that the future prospects of micro/nano-bubble related research will be tremendous and that there will be even more to be explored. In this case study, a bibliometric analysis was conducted to evaluate micro/nano-bubble related research from 1991 to 2014, based on the Science Citation Index EXPANDED database. The Ultrasound in Medicine and Biology with the highest h-index of 56 is the leading journal in this field, publishing 6.9 % of articles over this period, followed by Langmuir and Journal of the Acoustical Society of America. USA and the Univ Toronto, Canada were the most productive country and institution, respectively, while the USA, was the most internationally collaborative and had the highest hindex (111) of all countries. A new method named ''word cluster analysis'' was successfully applied to trace the research hotspots. Innovation in detection means and novel pathways for medical applications via micro/nano-bubble is considered to relate to the Electronic supplementary material The online version of this article

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Section: Author Abstractmentioning

confidence: 99%

Section: Hot Issues and Future Trendsmentioning

confidence: 99%

A bibliometric analysis of micro/nano-bubble related research: current trends, present application, and future prospects

Zheng

Wang

et al. 2016

Scientometrics

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“…To overcome these problems, the development of an efficient, safe and targeted delivery of irinotecan is required to reduce the therapeutic dose. Recent research has demonstrated that targeted drug delivery using ultrasound (US) combined with microbubbles, also known as sonoporation, offers new opportunities to improve the therapeutic effectiveness of tumor treatment and to reduce toxic exposure to healthy tissues 4,5 . Microbubbles under US activation oscillate and increase the permeability of biological barriers facilitating thus the drug extravasation into the treated tissue 6 .…”

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confidence: 99%

Irinotecan delivery by microbubble-assisted ultrasound - A pilot preclinical study

Escoffre¹,

Novell²,

Sérrière³

et al. 2012

AIP Conference Proceedings

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Abstract. Irinotecan is conventionally used for the treatment of colorectal cancer. However, its administration is associated with severe side effects. Targeted drug delivery using ultrasound (US) combined with microbubbles offers new opportunities to increase the therapeutic effectiveness of antitumor treatment and to reduce toxic exposure to healthy tissues. The objective of this study is to investigate the safety and efficacy of in-vivo delivery of irinotecan by microbubble-assisted US in human glioblastoma model (U-87 MG). In order to validate the potential of this new method in-vivo, subcutaneous tumors were implanted in the flank of nude mouse and treated when they reached a volume of 100 mm 3 . In the first study, the measured volumes with caliper and anatomic ultrasound imaging were compared for the monitoring and the quantification of tumor growth during 27 days. Ultrasound imaging measurements were positively correlated to caliper measurements. The tumor treatment consisted of an i.v. injection of irinotecan (20 mg/kg) followed one hour later by i.v. administration of MM1 microbubble and an US insonation using a single-element transducer operating at 1MHz (400 kPa, 10 kHz PRF 40% DC, 3 min). The therapeutic efficacy was evaluated for 39 days by measuring the tumor volume before and after treatment using a caliper and based on ultrasound images using an 18 MHz probe (Vevo 2100). Our results showed that anatomical ultrasound imaging was as efficient as caliper for the monitoring and the quantification of tumor growth. Moreover, irinotecan delivery by sonoporation induced a significant decrease of glioblastoma tumor volume and an increase of tumor-doubling time compared to the tumor treated by irinotecan alone. In conclusion, this novel therapeutic approach has promising features since it can be used to reduce the injected drug dose and to achieve a better therapeutic efficacy.

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“…Extensive and recent analyses of these promising strategies can be found [37,38]. Third, the penetration of drug (or genetic material) into cells can be enhanced by the process of sonoporation [39][40][41][42]. Finally, the amount of drug available in the targeted tissue can be increased by facilitating the crossing of a physiological barrier, as in the case of the blood-brain barrier [43].…”

Section: Mechanisms Of Ultrasound-mediated Drug Deliverymentioning

confidence: 99%

Ultrasound-mediated ocular delivery of therapeutic agents: a review

Lafond

Aptel

Mestas

et al. 2016

Expert Opinion on Drug Delivery

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Introduction: Due to numerous anatomical and physiological barriers, ocular drug delivery remains a major limitation in the treatment of diseases such as glaucoma, macular degeneration or inflammatory diseases. To date, only invasive approaches provide clinically effective results. Ultrasound can be defined as the propagation of a high-frequency sound wave exposing the propagation media to mechanical and thermal effects. Ultrasound has been proposed as a non-invasive physical agent for increasing therapeutic agent delivery in various fields of medicine.Areas Covered: An update on recent advances in transscleral and transcorneal ultrasoundmediated drug delivery is presented. Efficient drug delivery is achieved in vitro, ex vivo and in vivo for various types of materials. Numerous studies indicate that efficacy is related to Downloaded by [University of Lethbridge] at 02:55 18 June 2016 2 cavitation. Although slight reversible effects can be observed on the corneal epithelium, efficient drug delivery can be performed without causing damage to the cornea. Expert Opinion: Recent developments prove the potential of ultrasound-mediated ocular drug delivery. Cavitation appears to be a preponderant mechanism, opening a way to treatment monitoring by cavitation measurement. Even if no clinical studies have yet been performed, the promising results summarized here are promoting developments toward clinical applications, particularly in assessing the safety of the technique. Article highlights box• Ocular drug delivery limits the treatment of numerous diseases because of anatomical and physiological barriers so that current techniques are either inefficient (5% of the dose reaching the interior of the eye) or invasive (intravitreal injections, implants).• Ultrasound offers the possibility of acting noninvasively on the sclera or cornea.• Both in vitro and in vivo experiments report an increase in transscleral and transcorneal drug delivery by applying ultrasound which could suggest an increased treatment efficacy.• The mechanism of enhanced drug delivery is attributable to cavitation, producing slight, reversible changes in tissues.• Slight reversible damages attributable could be found. Thus, with an efficient cavitation monitoring procedure, translation to the clinic should be encouraged, as no severe damage has been observed. Downloaded by [University of Lethbridge] at 02:55 18 June 2016 3• The strategy of dosing the ultrasound exposure on measured cavitation activity in relation with its calibrated bioeffects in terms of damages and efficacy is proposed.Also, future developments shall benefit from the experience of sonophoresis.

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Doxorubicin Delivery into Tumor Cells with Ultrasound and Microbubbles

Cited by 115 publications

References 34 publications

A bibliometric analysis of micro/nano-bubble related research: current trends, present application, and future prospects

A bibliometric analysis of micro/nano-bubble related research: current trends, present application, and future prospects

Irinotecan delivery by microbubble-assisted ultrasound - A pilot preclinical study

Ultrasound-mediated ocular delivery of therapeutic agents: a review

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