Doxorubicin coupled to lactosaminated albumin: Effects on rats with liver fibrosis and cirrhosis

Stefano, Giuseppina Di; Fiume, L.; Domenicali, Marco; Busi, C.; Chieco, Pasquale; Kratz, Felix; Lanza, Marcella; Mattioli, A.; Pariali, M.; Bernardi, Mauro

doi:10.1016/j.dld.2006.02.010

Cited by 28 publications

(12 citation statements)

References 17 publications

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“…It caused a statistically significant but only moderate increase of serum aminotransferase levels. Parameters reflecting hepatocyte function, such as serum bilirubin and albumin, were not significantly affected (30).…”

Section: Discussionmentioning

confidence: 85%

A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentiation grade

Stefano¹,

Fiume²,

Baglioni³

et al. 2006

Liver International

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Section: Discussionmentioning

confidence: 85%

A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentiation grade

Stefano¹,

Fiume²,

Baglioni³

et al. 2006

Liver International

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“…Moreover, ASGPR are reported to be overexpressed in hepatic cancer (Trouet and Jolles, 1984 ). DOX coupled to lactosaminated human serum albumin has been extensively studied as hepatotropic carrier to improve the chemotherapeutic index of DOX in the treatment of hepatic cancer (Stefano et al 2006 ; Fiume et al 2008 ). Poly[N-(2-hydroxypropyl)methacrylamide] copolymer bearing DOX and galactosamine, known as PK2 was found to enhance hepatic targeting when evaluated in primary hepatocellular tumors (Julyan et al 1999 ; Seymour et al 2002 ).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of pullulan-functionalized doxorubicin nanoparticles for asialoglycoprotein receptor-mediated uptake in Hep G2 cell line

et al. 2011

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The present study discusses evaluation of pullulan-functionalized doxorubicin nanoparticles for asialoglycoprotein receptor-mediated uptake in the Hep G2 cell line. Doxorubicin hydrochloride (DOX) nanoparticles using polymers of different hydrophobic character, polyethylene sebacate (hydrophobic) and poly (lactic-co-glycolic acid) (intermediate hydrophobicity) with high entrapment efficiency and particle size were prepared by modified nanoprecipitation, using Gantrez AN 119 as complexing agent. Nanoparticles of Gantrez AN 119 were also prepared to represent a hydrophilic polymer. Cell uptake of DOX nanoparticles was found to be comparable to DOX solution irrespective of DOX concentration, nanoparticles size, and pullulan concentration. Furthermore, uptake of nanoparticles functionalized with or without pullulan prepared with polymers of different hydrophobic character revealed comparable uptake. Comparable uptake of DOX solution and DOX nanoparticles functionalized with or without pullulan suggest extracellular release of DOX as the mechanism of uptake from the nanoparticles. In vivo evaluation in hepatic cancer model is therefore essential to confirm the role of pullulan as asialoglycoprotein receptors ligand.

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“…Using cancer model cell lines, various methods have been developed to improve doxorubicin efficacy and/or delivery. These methods comprise so far: (a) entrapping the drug in submicron carriers like liposomes, (b) using polymeric micelles, (c) coupling to nanoparticules or lactosaminated human albumin (25)(26)(27)(28)(29).…”

Section: Introductionmentioning

confidence: 99%

Maurocalcine as a Non Toxic Drug Carrier Overcomes Doxorubicin Resistance in the Cancer Cell Line MDA-MB 231

et al. 2008

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Doxorubicin coupled to lactosaminated albumin: Effects on rats with liver fibrosis and cirrhosis

Cited by 28 publications

References 17 publications

A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentiation grade

A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentiation grade

Evaluation of pullulan-functionalized doxorubicin nanoparticles for asialoglycoprotein receptor-mediated uptake in Hep G2 cell line

Maurocalcine as a Non Toxic Drug Carrier Overcomes Doxorubicin Resistance in the Cancer Cell Line MDA-MB 231

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